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blaB1PEDO

subclass B1 metallo-beta-lactamase PEDO-3

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaB1PEDO

Browse AMR rules for blaB1PEDO

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic inactivation
Validation Method: synthesis and expression in E. coli followed by CarbaNP test
Drug Classes: MEROPENEM, ERTAPENEM, AMOXICILLIN, CEFOXITIN, IMIPENEM, CEFIXIME, CEFEPIME, AMPICILLIN+CLAVULANIC ACID, AMPICILLIN, CARBAPENEM, CEFOTAXIME, CEFTAZIDIME, AMOXICILLIN+CLAVULANIC ACID, PIPERACILLIN+TAZOBACTAM, PIPERACILLIN, Carbapenem, Penicillin, Oxacillin, Ampicillin, Amoxicillin, Cephalosporin, Ceftriaxone, Cefepime, Meropenem, Aztreonam
Organisms: Pedobacter sp. Stok-3, Escherichia coli
Geographic Location: Japan|Fiji|Europe|China|USA|Germany|France|Denmark|Canada|Madagascar|Kazakhstan|Mongolia|Ethiopia|Peru|Sweden|Italy|Korea|UK|Austria|Hungary
Alleles: 3
Papers: 3
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
blaPEDO-3	Card DatabaseReference Gene CatalogResFinder Database	4	MEROPENEM, ERTAPENEM +13	Pedobacter sp. Stok-3	-	2016

Papers3

1

The Soil Microbiota Harbors a Diversity of Carbapenem-Hydrolyzing β-Lactamases of Potential Clinical Relevance.

PMID 26482314 · 2016

Gene Information

Gene Name: blaB1PEDO
Allele: blaPEDO-3
Encodes: subclass B1 metallo-beta-lactamase PEDO-3
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pedobacter sp. Stok-3
Sequence Accession: KP109679.1
Protein Accession: AJP77076.1
Notes: Chromosomal metallo-beta-lactamase

2

The Soil Microbiota Harbors a Diversity of Carbapenem-Hydrolyzing β-Lactamases of Potential Clinical Relevance.

PMID 26482314 · 2016

Gene Information

Gene Name: blaB1PEDO
Allele: blaPEDO-3
Encodes: subclass B1 metallo-beta-lactamase PEDO-3
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pedobacter sp. Stok-3
Sequence Accession: KP109679.1
Protein Accession: AJP77076.1
Notes: Chromosomal metallo-beta-lactamase

3

The Soil Microbiota Harbors a Diversity of Carbapenem-Hydrolyzing β-Lactamases of Potential Clinical Relevance.

PMID 26482314 · 2016

Gene Information

Gene Name: blaB1PEDO
Allele: blaPEDO-3
Encodes: subclass B1 metallo-beta-lactamase PEDO-3
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pedobacter sp. Stok-3
Sequence Accession: KP109679.1
Protein Accession: AJP77076.1
Notes: Chromosomal metallo-beta-lactamase

4

The Soil Microbiota Harbors a Diversity of Carbapenem-Hydrolyzing β-Lactamases of Potential Clinical Relevance.

PMID 26482314 · 2016

Gene Information

Gene Name: blaB1PEDO
Allele: blaPEDO-3
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pedobacter sp. Stok-3
Sequence Accession: KP109679
Notes: Chromosomal metallo-beta-lactamase

5

Development and evaluation of fARGene, a computational tool for the detection of antibiotic resistance genes in metagenomic data

PMID 30935407 · 2023

The study presents fARGene, a method for identifying and reconstructing antibiotic resistance genes from metagenomic data, demonstrating the detection of 221 ARGs, 58 of which were previously unreported, with 81% providing a resistance phenotype in E. coli.

Gene Information

Gene Name: blaB1PEDO
Allele: blaB1
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: Carbapenem
Organisms Tested In: • Escherichia coli
Validation Method: synthesis and expression in E. coli followed by CarbaNP test

6

Expanding the beta-lactamase Family in the Human Microbiome.

PMID 39447121 · 2024

The study identifies nine novel beta-lactamases from eight distinct clusters, demonstrating their ability to confer resistance to various β-lactam antibiotics. These enzymes were experimentally validated through expression in E. coli and MIC testing.

Gene Information

Gene Name: blaB1PEDO
Allele: blaB1
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: PenicillinOxacillinAmpicillinAmoxicillinCephalosporinCeftriaxoneCefepimeMeropenemAztreonam
Organisms Tested In: • Escherichia coli
Geographic Location: Japan|Fiji|Europe|China|USA|Germany|France|Denmark|Canada|Madagascar|Kazakhstan|Mongolia|Ethiopia|Peru|Sweden|Italy|Korea|UK|Austria|Hungary
Validation Method: expression in E. coli and MIC testing

7

Gene Information

Gene Name: blaB1PEDO
Allele: blaB3PEDO-3
Encodes: subclass B1 PEDO beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Pedobacter sp. Stok-3
Sequence Accession: KP109679.1
Protein Accession: AJP77076.1
Notes: ARO:3003715