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subclass B3 metallo-beta-lactamase PEDO-1
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaPEDO-2 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | MEROPENEM, ERTAPENEM +14 | Pedobacter sp. ALS-14 |
| Norway |
| 2016, 2020 |
| KP109678 |
| AJP77071.1 |
| blaPEDO-1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | MEROPENEM, ERTAPENEM +20 | Pedobacter sp. SI-33 +1 | Denmark|Germany|Algeria|Spain|Norway | 2016 | KP109677 | AJP77059.1 |
| blaB3PEDO-2 | Card Database | 1 | - | Pedobacter sp. ALS-14 | - | - | KP109678.1 | AJP77071.1 |
| BlaB3PEDO-1 | Card Database | 1 | - | Pedobacter sp. SI-33 | - | - | KP109677.1 | AJP77059.1 |
The Soil Microbiota Harbors a Diversity of Carbapenem-Hydrolyzing β-Lactamases of Potential Clinical Relevance.
The Soil Microbiota Harbors a Diversity of Carbapenem-Hydrolyzing β-Lactamases of Potential Clinical Relevance.
The Soil Microbiota Harbors a Diversity of Carbapenem-Hydrolyzing β-Lactamases of Potential Clinical Relevance.
The Soil Microbiota Harbors a Diversity of Carbapenem-Hydrolyzing β-Lactamases of Potential Clinical Relevance.
The Soil Microbiota Harbors a Diversity of Carbapenem-Hydrolyzing β-Lactamases of Potential Clinical Relevance.
The Soil Microbiota Harbors a Diversity of Carbapenem-Hydrolyzing β-Lactamases of Potential Clinical Relevance.
The Soil Microbiota Harbors a Diversity of Carbapenem-Hydrolyzing β-Lactamases of Potential Clinical Relevance.
The Soil Microbiota Harbors a Diversity of Carbapenem-Hydrolyzing β-Lactamases of Potential Clinical Relevance.
Expanding the Repertoire of Carbapenem-Hydrolyzing Metallo-ß-Lactamases by Functional Metagenomic Analysis of Soil Microbiota.
Nine carbapenem-hydrolyzing metallo-beta-lactamases (MBLs) were identified in soil microbiota using functional metagenomics. These MBLs included two subclass B1 (GRD23-1 and SPN79-1) and seven subclass B3 (CRD3-1, PEDO-1, GRD33-1, ESP-2, ALG6-1, ALG11-1, and DHT2-1). All MBLs conferred resistance to various β-lactam antibiotics in E. coli.
Whole genome sequencing and antibiotic diffusion assays, provide new insight on drug resistance in the genus Pedobacter.
The study identifies several AMR genes in Pedobacter isolates, including a metallo-beta-lactamase gene (pedo-2) and genes encoding multidrug efflux pumps (bcrA, mexI). These genes contribute to resistance against carbapenems and other antibiotics.
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