Browse AMR Genes

Explore antimicrobial resistance genes from the literature

blaB3SU1

metallo-beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaB3SU1

Browse AMR rules for blaB3SU1

Validation StatusConfirmed2+ DBs

Overview

Mechanism: hydrolysis of beta-lactam antibiotics
Validation Method: PCR and sequencing
Drug Classes: Carbapenem, CEPHALOSPORIN
Organisms: Chryseobacterium (Flavobacterium) meningosepticum, Escherichia coli, Cedecea neteri SSMD04, Sphingomonas, uncultured bacterium
Geographic Location: Europe|global, France|Baulon|Crozon|Plounéour-Ménez|Trégastel, United Kingdom|USA|France
Alleles: 3
Papers: 5
Databases: Card DatabaseReference Gene CatalogReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
blaB3	Reslit	4	Carbapenem	Chryseobacterium (Flavobacterium) meningosepticum +3	United Kingdom\|USA\|France, Europe\|global, France\|Baulon\|Crozon\|Plounéour-Ménez\|Trégastel	2000, 2021, 2022, 2023	AF126542\|AF162284	-
blaB3SU1

Papers5

1

Carbapenemases of Chryseobacterium (Flavobacterium) meningosepticum: distribution of blaB and characterization of a novel metallo-beta-lactamase gene, blaB3, in the type strain, NCTC 10016.

PMID 10817691 · 2000

The study characterizes the blaB, blaB2, and blaB3 genes, which encode metallo-beta-lactamases in Chryseobacterium (Flavobacterium) meningosepticum, contributing to carbapenem resistance.

Gene Information

Gene Name: blaB3SU1
Allele: blaB3
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: Carbapenem
Organisms Tested In: • Chryseobacterium (Flavobacterium) meningosepticum
Geographic Location: United Kingdom|USA|France
Validation Method: PCR and sequencing
Sequence Accession: AF126542|AF162284

2

Development and evaluation of fARGene, a computational tool for the detection of antibiotic resistance genes in metagenomic data

PMID 30935407 · 2023

The study presents fARGene, a method for identifying and reconstructing antibiotic resistance genes from metagenomic data, demonstrating the detection of 221 ARGs, 58 of which were previously unreported, with 81% providing a resistance phenotype in E. coli.

Gene Information

Gene Name: blaB3SU1
Allele: blaB3
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: Carbapenem
Organisms Tested In: • Escherichia coli
Validation Method: synthesis and expression in E. coli followed by CarbaNP test

3

Genomic Insights into Drug Resistance Determinants in Cedecea neteri, A Rare Opportunistic Pathogen.

PMID 34442820 · 2021

The study identifies multiple beta-lactamase genes, including a novel CMY/ACT-type AmpC beta-lactamase and several metallo-beta-lactamases, as well as multidrug efflux pumps in Cedecea neteri, highlighting its resistance mechanisms against various antibiotics.

Gene Information

Gene Name: blaB3SU1
Allele: blaB3
Encodes: Metallo-beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of beta-lactam antibiotics
Confers Resistance To: Carbapenem
Organisms Tested In: • Cedecea neteri SSMD04
Geographic Location: Europe|global
Validation Method: sequence analysis and motif identification
Sequence Accession: CP009451.1|CP009458.1|CP009459.1|CP011077.1|NZ_CP009451.1|NZ_CP011077.1

4

Rhizocarpon geographicum Lichen Discloses a Highly Diversified Microbiota Carrying Antibiotic Resistance and Persistent Organic Pollutant Tolerance.

PMID 36144461 · 2022

The study identified multiple AMR genes in lichen-associated bacteria, including beta-lactamases, efflux pump components, and enzymes conferring resistance to various antibiotics. These findings highlight the diverse AMR profiles of bacteria inhabiting extreme environments.

Gene Information

Gene Name: blaB3SU1
Allele: blaB3
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: Carbapenem
Organisms Tested In: • Sphingomonas
Geographic Location: France|Baulon|Crozon|Plounéour-Ménez|Trégastel
Validation Method: whole-genome sequencing and AMR protein detection

5

Functional metagenomics reveals wildlife as natural reservoirs of novel β-lactamases.

PMID 36626997 · 2023

Gene Information

Gene Name: blaB3SU1
Allele: blaB3SU1
Encodes: subclass B3 metallo-beta-lactamase B3SU1-1
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • uncultured bacterium
Sequence Accession: MZ126683.1
Protein Accession: QWJ89341.1
Notes: ARO:3008078

6

Functional metagenomics reveals wildlife as natural reservoirs of novel β-lactamases.

PMID 36626997 · 2023

Gene Information

Gene Name: blaB3SU1
Allele: blaB3SU1
Encodes: subclass B3 metallo-beta-lactamase B3SU1-1
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • uncultured bacterium
Sequence Accession: MZ126683.1
Protein Accession: QWJ89341.1
Notes: ARO:3008078

7

Gene Information

Gene Name: blaB3SU1
Allele: blaB3SU1-1
Encodes: B3SU1 beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • uncultured bacterium
Sequence Accession: MZ126683.1
Protein Accession: QWJ89341.1
Notes: ARO:3008078