blaBES

extended spectrum class A beta-lactamase BES-1

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic inactivation
Validation Method: cloning and sequencing
Drug Classes: TICARCILLIN, CEPHALOSPORIN, AMOXICILLIN, CEFOXITIN, TICARCILLIN+CLAVULANIC ACID, AMPICILLIN+CLAVULANIC ACID, AMPICILLIN, CEFOTAXIME, CEFTAZIDIME, AMOXICILLIN+CLAVULANIC ACID, PIPERACILLIN+TAZOBACTAM, PIPERACILLIN, Ceftazidime, Cefotaxime, Aztreonam, Penicillin, Carbapenem, Cephalosporin
Organisms: Serratia marcescens, Escherichia coli, Acinetobacter baumannii, Pantoea
Geographic Location: Alaska, Brazil, Brazil|Germany
Papers: 3
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Papers3

A novel class A extended-spectrum beta-lactamase (BES-1) in Serratia marcescens isolated in Brazil.

PMID 11036023 · 2000

Gene Information

Gene Name: blaBES
Allele: blaBES-1
Encodes: extended spectrum class A beta-lactamase BES-1
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINTICARCILLIN+CLAVULANIC ACIDAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Serratia marcescens
Sequence Accession: AF234999.1
Protein Accession: AAF61147.1
Notes: ARO:3004751

A novel class A extended-spectrum beta-lactamase (BES-1) in Serratia marcescens isolated in Brazil.

PMID 11036023 · 2000

Gene Information

Gene Name: blaBES
Allele: blaBES-1
Encodes: extended spectrum class A beta-lactamase BES-1, BES Beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINTICARCILLIN+CLAVULANIC ACIDAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Serratia marcescens
Sequence Accession: AF234999.1
Protein Accession: AAF61147.1
Notes: ARO:3004751

A novel class A extended-spectrum beta-lactamase (BES-1) in Serratia marcescens isolated in Brazil.

PMID 11036023 · 2000

Gene Information

Gene Name: blaBES
Allele: blaBES-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINCEFOXITINTICARCILLIN+CLAVULANIC ACIDAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Serratia marcescens
Sequence Accession: AF234999

A novel class A extended-spectrum beta-lactamase (BES-1) in Serratia marcescens isolated in Brazil.

PMID 11036023 · 2000

The study identifies a novel class A extended-spectrum beta-lactamase, BES-1, in Serratia marcescens isolated in Brazil, which confers resistance to ceftazidime, cefotaxime, and aztreonam.

Gene Information

Gene Name: blaBES
Allele: blaBES-1
Encodes: class A extended-spectrum beta-lactamase
Source Database: Reslit
Confers Resistance To: CeftazidimeCefotaximeAztreonam
Organisms Tested In: • Serratia marcescens
• Escherichia coli
Geographic Location: Brazil
Validation Method: cloning and sequencing
Sequence Accession: AF234999

A novel class A extended-spectrum beta-lactamase (BES-1) in Serratia marcescens isolated in Brazil.

PMID 11036023 · 2000

Gene Information

Gene Name: blaBES
Allele: blaBES-1
Encodes: extended spectrum class A beta-lactamase BES-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINTICARCILLIN+CLAVULANIC ACIDAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Serratia marcescens
Sequence Accession: AF234999.1
Protein Accession: AAF61147.1
Notes: ARO:3004751

Complete sequence of broad-host-range plasmid pRIO-5 harboring the extended-spectrum-beta-lactamase gene blaBES-1.

PMID 22083487 · 2012

The study characterizes the broad-host-range plasmid pRIO-5 harboring the extended-spectrum beta-lactamase gene blaBES-1, which confers resistance to several β-lactam antibiotics.

Gene Information

Gene Name: blaBES
Allele: blaBES-1
Encodes: extended-spectrum beta-lactamase
Source Database: Reslit
Mechanism: confers resistance to penicillins, aztreonam, and cefotaxime and to a lesser extent to ceftazidime
Confers Resistance To: PenicillinAztreonamCefotaximeCeftazidime
Organisms Tested In: • Serratia marcescens
• Escherichia coli
• Acinetobacter baumannii
Geographic Location: Brazil|Germany
Validation Method: expression in E. coli and A. baumannii with decreased susceptibility to ceftazidime
Sequence Accession: JF785550

Unearthing Antibiotic Resistance Associated with Disturbance-Induced Permafrost Thaw in Interior Alaska.

PMID 33418967 · 2021

The study identified various antibiotic resistance genes in Alaskan soil bacteria, highlighting the influence of phylogeny and disturbance on the resistome. Key genes included adeF, AbaQ, FosB, BcII, bcrC, TriC, KpnF, and BES-1, which conferred resistance to multidrug, quinolones, penicillins, cephalosporins, peptide antibiotics, triclosan, and broad-spectrum antibiotics.

Gene Information

Gene Name: blaBES
Allele: blaBES-1
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: beta-lactam inactivation
Confers Resistance To: CarbapenemCephalosporin
Organisms Tested In: • Pantoea
Geographic Location: Alaska
Validation Method: whole genome sequencing and annotation

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