Browse AMR Genes

Explore antimicrobial resistance genes from the literature

blaBIC

carbapenem-hydrolyzing beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaBIC

Browse AMR rules for blaBIC

Validation StatusConfirmed2+ DBs

Overview

Mechanism: hydrolysis of penicillins, carbapenems, and cephalosporins
Validation Method: cloning in E. coli + MIC testing
Drug Classes: Penicillin, Carbapenem, Cephalosporin, TICARCILLIN, AMOXICILLIN, IMIPENEM, TICARCILLIN+CLAVULANIC ACID, AMPICILLIN+CLAVULANIC ACID, AMPICILLIN, CARBAPENEM, AMOXICILLIN+CLAVULANIC ACID, PIPERACILLIN+TAZOBACTAM, PIPERACILLIN, Meropenem
Organisms: Pseudomonas fluorescens, Escherichia coli, Enterobacter cloacae, Acinetobacter spp., Pantoea agglomerans, Providencia alcalifaciens
Geographic Location: Europe|Greece, Paris, France, Poland, USA|Global
Alleles: 3
Papers: 5
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
blaBIC-1	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	7	Penicillin, Carbapenem +11

Papers5

1

Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France.

PMID 19901091 · 2010

A novel Ambler class A carbapenemase, BIC-1, was identified in a Pseudomonas fluorescens isolate from the Seine River, Paris, France. BIC-1 hydrolyzes penicillins, carbapenems, and cephalosporins except ceftazidime and monobactams.

Gene Information

Gene Name: blaBIC
Allele: blaBIC-1
Encodes: carbapenem-hydrolyzing beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of penicillins, carbapenems, and cephalosporins
Confers Resistance To: PenicillinCarbapenemCephalosporin
Organisms Tested In: • Pseudomonas fluorescens
• Escherichia coli
Geographic Location: Paris, France
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: GQ260093

2

Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France.

PMID 19901091 · 2010

Gene Information

Gene Name: blaBIC
Allele: blaBIC-1
Encodes: carbapenem-hydrolyzing class A beta-lactamase BIC-1
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINIMIPENEMTICARCILLIN+CLAVULANIC ACIDAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas fluorescens
Sequence Accession: GQ260093.1
Protein Accession: ADB56658.1
Notes: ARO:3004753

3

Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France.

PMID 19901091 · 2010

Gene Information

Gene Name: blaBIC
Allele: blaBIC-1
Encodes: carbapenem-hydrolyzing class A beta-lactamase BIC-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINIMIPENEMTICARCILLIN+CLAVULANIC ACIDAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas fluorescens
Sequence Accession: GQ260093.1
Protein Accession: ADB56658.1
Notes: ARO:3004753

4

Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France.

PMID 19901091 · 2010

Gene Information

Gene Name: blaBIC
Allele: blaBIC-1
Encodes: carbapenem-hydrolyzing class A beta-lactamase BIC-1, BIC Beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINIMIPENEMTICARCILLIN+CLAVULANIC ACIDAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas fluorescens
Sequence Accession: GQ260093.1
Protein Accession: ADB56658.1
Notes: ARO:3004753

5

Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France.

PMID 19901091 · 2010

Gene Information

Gene Name: blaBIC
Allele: blaBIC-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINIMIPENEMAMOXICILLINTICARCILLIN+CLAVULANIC ACIDAMPICILLIN+CLAVULANIC ACIDAMPICILLINAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas fluorescens
Sequence Accession: GQ260093

6

Class A Carbapenemases: Mechanisms of Action and Resistance

The paper characterizes various class A carbapenemases, including KPC, GES, SME, NmcA, FRI-1, BIC-1, SFC-1, and PenA, highlighting their roles in conferring resistance to carbapenems and other β-lactam antibiotics.

Gene Information

Gene Name: blaBIC
Allele: blaBIC-1
Encodes: serine beta-lactamase
Source Database: Reslit
Confers Resistance To: CarbapenemPenicillinCephalosporin
Organisms Tested In: • Enterobacter cloacae
Geographic Location: USA|Global
Validation Method: experimental validation through cloning and MIC testing
Sequence Accession: PDB:3E2K|PDB:3E2L|PDB:3RXW|PDB:3RXX|PDB:3NI9|PDB:3NIA|PDB:4QU3|PDB:4GNU|PDB:4H8R|PDB:3V3S|PDB:4EQI|PDB:4EUZ|PDB:4EV4|PDB:1BUE|PDB:1BUL|PDB:1DY6|PDB:3W4Q

7

Prevalence, Characterization, and Epidemiological Relationships between ESBL and Carbapenemase-Producing Escherichia coli, Klebsiella pneumoniae, and Acinetobacter spp. Isolated from Humans and the Kitchen Environment of Two Greek Hospitals.

PMID 39452201 · 2024

The study identified various beta-lactamase genes, including bla SHV, bla CTX-M, bla TEM, bla KPC, bla NDM, bla OXA-48, bla OXA-23, and bla OXA-51, in ESBL and carbapenemase-producing E. coli, K. pneumoniae, and Acinetobacter spp. isolates from hospital kitchens and staff.

Gene Information

Gene Name: blaBIC
Allele: blaBIC
Encodes: carbapenemase
Source Database: Reslit
Confers Resistance To: Meropenem
Organisms Tested In: • Acinetobacter spp.
Geographic Location: Europe|Greece
Validation Method: PCR and sequencing

8

Antibiotic resistance in white stork cloaca and environmental samples

PMID 41031806 · 2023

The study identified various antibiotic resistance genes in bacterial isolates from white stork cloaca and environmental samples, highlighting the presence of resistance mechanisms against beta-lactams, aminoglycosides, quinolones, and polymyxins.

Gene Information

Gene Name: blaBIC
Allele: blaBIC-1
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: Carbapenem
Organisms Tested In: • Escherichia coli
• Enterobacter cloacae
• Pantoea agglomerans
• Providencia alcalifaciens
Geographic Location: Poland
Validation Method: PCR detection

9

PMID Unpublished

Gene Information

Gene Name: blaBIC
Allele: blaBIC-2
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINIMIPENEMAMOXICILLINTICARCILLIN+CLAVULANIC ACIDAMPICILLIN+CLAVULANIC ACIDAMPICILLINAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas fluorescens
Sequence Accession: OR143113

10

Gene Information

Gene Name: blaBIC
Allele: blaBIC-2
Encodes: carbapenem-hydrolyzing class A beta-lactamase BIC-2
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINIMIPENEMTICARCILLIN+CLAVULANIC ACIDAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas fluorescens
Sequence Accession: OR143113.1
Protein Accession: WKD79667.1
Notes: ARO:3008080

11

Gene Information

Gene Name: blaBIC
Allele: blaBIC-2
Encodes: carbapenem-hydrolyzing class A beta-lactamase BIC-2, BIC Beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINIMIPENEMTICARCILLIN+CLAVULANIC ACIDAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas fluorescens
Sequence Accession: OR143113.1
Protein Accession: WKD79667.1
Notes: ARO:3008080

12

Gene Information

Gene Name: blaBIC
Allele: blaBIC-2
Encodes: carbapenem-hydrolyzing class A beta-lactamase BIC-2
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINIMIPENEMTICARCILLIN+CLAVULANIC ACIDAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Pseudomonas fluorescens
Sequence Accession: OR143113.1
Protein Accession: WKD79667.1
Notes: ARO:3008080