Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ResLit

blaCARB

class A beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to blaCARB

AMR Rules

Browse AMR rules for blaCARB

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic inactivation
Validation Method: expression in E. coli and MIC testing
Drug Classes: AMOXICILLIN, AMPICILLIN, PIPERACILLIN, BETA-LACTAM, Penicillin, Ampicillin, Piperacillin, Imipenem, Meropenem, Ampicillin/sulbactam, Amoxicillin, Carbapenem, Beta-lactams, Cephalothin, Ceftazidime, Cefotaxime
Organisms: Vibrio parahaemolyticus, Oligella urethralis, Escherichia coli, Vibrio parahaemolyticus CFSAN001595, Vibrio parahaemolyticus O1:Kuk str. FDA_R31, Vibrio parahaemolyticus S164, Vibrio parahaemolyticus S141, Vibrio parahaemolyticus TUMSAT_H10_S6, Vibrio parahaemolyticus TUMSAT_H03_S5, Vibrio parahaemolyticus TUMSAT_DE2_S2, Vibrio parahaemolyticus TUMSAT_DE1_S1, Vibrio parahaemolyticus S146, Vibrio parahaemolyticus S105, Vibrio parahaemolyticus S024, Vibrio parahaemolyticus S023, Vibrio parahaemolyticus S014, Vibrio parahaemolyticus M0605, Vibrio parahaemolyticus S115, Vibrio parahaemolyticus S174, Vibrio parahaemolyticus S020, Vibrio parahaemolyticus S037, Vibrio parahaemolyticus S054, Vibrio parahaemolyticus S100, Vibrio cholerae, Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica serovar Typhimurium, Vibrio alginolyticus, Vibrio metschnikovii, Vibrio antiquarius, Vibrio spp., Vibrio, Acinetobacter baumannii, Salmonella enterica, Photobacterium damselae subsp. damselae, Vibrio parahaemolyticus VPTS-2009, Vibrio parahaemolyticus NIHCB0757, Vibrio parahaemolyticus RIMD 2210633, Vibrio diabolicus, Vibrio parahaemolyticus UCM-V493
Geographic Location: Bangkok|eastern Thailand|Thailand, China, Egypt, France|Ecuador|Vietnam|India|Madagascar|Nigeria, Hong Kong|Shenzhen +10 more
Alleles: 37
Papers: 28
Databases: Card DatabaseReference Gene CatalogResFinder Database

Allele Variants37

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
blaCARB-22	Card DatabaseReference Gene CatalogResFinder Database	4	AMOXICILLIN, AMPICILLIN +2	Vibrio parahaemolyticus +1	-	2000	JYNG01000059

Papers28

A filamentous phage associated with recent pandemic Vibrio parahaemolyticus O3:K6 strains.

PMID 10834969 · 2000

Gene Information

Gene Name: blaCARB
Allele: blaCARB-22
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: JYNG01000059
Notes: Class A

Chromosomal Integration of a Cephalosporinase Gene from Acinetobacter baumannii into Oligella urethralis as a Source of Acquired Resistance to β-Lactams.

PMID 12709319 · 2003

The study identifies two beta-lactamase genes, bla_ABA-1 and bla_CARB-8, which confer resistance to β-lactam antibiotics in Oligella urethralis. These genes were chromosomally integrated and showed resistance to various β-lactam drugs.

Gene Information

Gene Name: blaCARB
Allele: bla_CARB-8
Encodes: class A beta-lactamase
Source Database: Reslit
Organisms Tested In: • Oligella urethralis
• Escherichia coli
Validation Method: expression in E. coli and MIC testing
Sequence Accession: AY177427|AY178993|AY178995|AY178996

Complete Genome Sequence of Prepandemic Vibrio parahaemolyticus BB22OP.

PMID 23469330 · 2013

Gene Information

Gene Name: blaCARB
Allele: blaCARB-20
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-20
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus CFSAN001595
Sequence Accession: JFFP02000005.1
Protein Accession: OMC60245.1
Notes: Class A

Complete Genome Sequence of Prepandemic Vibrio parahaemolyticus BB22OP.

PMID 23469330 · 2013

Gene Information

Gene Name: blaCARB
Allele: blaCARB-20
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-20
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus CFSAN001595
Sequence Accession: JFFP02000005.1
Protein Accession: OMC60245.1
Notes: Class A

Complete Genome Sequence of Prepandemic Vibrio parahaemolyticus BB22OP.

PMID 23469330 · 2013

Gene Information

Gene Name: blaCARB
Allele: blaCARB-20
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-20
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus CFSAN001595
Sequence Accession: JFFP02000005.1
Protein Accession: OMC60245.1
Notes: Class A

Comparison of metabolic capacities and inference of gene content evolution in mosquito-associated Spiroplasma diminutum and S. taiwanense.

PMID 23873917 · 2013

Gene Information

Gene Name: blaCARB
Allele: blaCARB-21
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-21
Source Database: Reference Gene Catalog
Confers Resistance To: BETA-LACTAM
Organisms Tested In: • Vibrio parahaemolyticus O1:Kuk str. FDA_R31
Sequence Accession: CP006005.1

Complete Genome Sequence of Vibrio parahaemolyticus Environmental Strain UCM-V493.

PMID 24625868 · 2014

Gene Information

Gene Name: blaCARB
Allele: blaCARB-23
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Sequence Accession: 48726
Notes: Class A

Draft Genome Sequences of Clinical Vibrio parahaemolyticus Strains Isolated in Maryland (2010 to 2013).

PMID 25103764 · 2014

Gene Information

Gene Name: blaCARB
Allele: blaCARB-46
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-46
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: JNTF02000020.1
Protein Accession: OQU55212.1
Notes: Class A, manually predicted phenotype

Draft Genome Sequences of Clinical Vibrio parahaemolyticus Strains Isolated in Maryland (2010 to 2013).

PMID 25103764 · 2014

Gene Information

Gene Name: blaCARB
Allele: blaCARB-46
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-46
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: JNTF02000020.1
Protein Accession: OQU55212.1
Notes: Class A, manually predicted phenotype

Draft Genome Sequences of Clinical Vibrio parahaemolyticus Strains Isolated in Maryland (2010 to 2013).

PMID 25103764 · 2014

Gene Information

Gene Name: blaCARB
Allele: blaCARB-46
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-46
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: JNTF02000020.1
Protein Accession: OQU55212.1
Notes: Class A, manually predicted phenotype

Draft Genome Sequences of Four Vibrio parahaemolyticus Isolates from Clinical Cases in Canada.

PMID 25635013 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-45
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-45
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: JTGR01000061.1
Protein Accession: KHF09587.1
Notes: Class A, manually predicted phenotype

Draft Genome Sequences of Four Vibrio parahaemolyticus Isolates from Clinical Cases in Canada.

PMID 25635013 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-44
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-44
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: JTGS01000066.1
Protein Accession: KHF12803.1
Notes: Class A, manually predicted phenotype

Draft Genome Sequences of Four Vibrio parahaemolyticus Isolates from Clinical Cases in Canada.

PMID 25635013 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-44
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-44
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: JTGS01000066.1
Protein Accession: KHF12803.1
Notes: Class A, manually predicted phenotype

Draft Genome Sequences of Four Vibrio parahaemolyticus Isolates from Clinical Cases in Canada.

PMID 25635013 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-44
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-44
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: JTGS01000066.1
Protein Accession: KHF12803.1
Notes: Class A, manually predicted phenotype

Draft Genome Sequences of Four Vibrio parahaemolyticus Isolates from Clinical Cases in Canada.

PMID 25635013 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-45
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: JTGR01000061
Notes: Class A, manually predicted phenotype

Draft Genome Sequences of Four Vibrio parahaemolyticus Isolates from Clinical Cases in Canada.

PMID 25635013 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-44
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: JTGS01000066
Notes: Class A, manually predicted phenotype

Draft Genome Sequences of Four Vibrio parahaemolyticus Isolates from Clinical Cases in Canada.

PMID 25635013 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-45
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-45
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: JTGR01000061.1
Protein Accession: KHF09587.1
Notes: Class A, manually predicted phenotype

Draft Genome Sequences of Four Vibrio parahaemolyticus Isolates from Clinical Cases in Canada.

PMID 25635013 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-45
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-45
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: JTGR01000061.1
Protein Accession: KHF09587.1
Notes: Class A, manually predicted phenotype

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-38
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S164
Sequence Accession: BK008898
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-35
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S141
Sequence Accession: BK008900
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-43
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-43
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus TUMSAT_H10_S6
Sequence Accession: BK008891.1
Protein Accession: DAA64855.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-42
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-42
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus TUMSAT_H03_S5
Sequence Accession: BK008894.1
Protein Accession: DAA64858.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-42
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-42
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus TUMSAT_H03_S5
Sequence Accession: BK008894.1
Protein Accession: DAA64858.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-42
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-42
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus TUMSAT_H03_S5
Sequence Accession: BK008894.1
Protein Accession: DAA64858.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-41
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-41
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus TUMSAT_DE2_S2
Sequence Accession: BK008890.1
Protein Accession: DAA64854.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-41
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-41
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus TUMSAT_DE2_S2
Sequence Accession: BK008890.1
Protein Accession: DAA64854.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-41
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-41
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus TUMSAT_DE2_S2
Sequence Accession: BK008890.1
Protein Accession: DAA64854.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-40
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-40
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus TUMSAT_DE1_S1
Sequence Accession: BK008889.1
Protein Accession: DAA64853.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-40
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-40
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus TUMSAT_DE1_S1
Sequence Accession: BK008889.1
Protein Accession: DAA64853.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-40
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-40
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus TUMSAT_DE1_S1
Sequence Accession: BK008889.1
Protein Accession: DAA64853.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-38
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-38
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S164
Sequence Accession: BK008898.1
Protein Accession: DAA64862.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-38
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-38
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S164
Sequence Accession: BK008898.1
Protein Accession: DAA64862.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-43
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-43
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus TUMSAT_H10_S6
Sequence Accession: BK008891.1
Protein Accession: DAA64855.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-43
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-43
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus TUMSAT_H10_S6
Sequence Accession: BK008891.1
Protein Accession: DAA64855.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-17
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-17
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: KJ934265.1
Protein Accession: AIL92326.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-17
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-17
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: KJ934265.1
Protein Accession: AIL92326.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-17
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-17, CARB beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: KJ934265.1
Protein Accession: AIL92326.1
Notes: Class A, ARO:3002254

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-38
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-38
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S164
Sequence Accession: BK008898.1
Protein Accession: DAA64862.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-36
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-36
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S146
Sequence Accession: BK008902.1
Protein Accession: DAA64866.1
Notes: Class A, manually predicted phenotype

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-36
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-36
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S146
Sequence Accession: BK008902.1
Protein Accession: DAA64866.1
Notes: Class A, manually predicted phenotype

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-36
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-36
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S146
Sequence Accession: BK008902.1
Protein Accession: DAA64866.1
Notes: Class A, manually predicted phenotype

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-35
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-35
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S141
Sequence Accession: BK008900.1
Protein Accession: DAA64864.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-35
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-35
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S141
Sequence Accession: BK008900.1
Protein Accession: DAA64864.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-33
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-33
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S105
Sequence Accession: BK008903.1
Protein Accession: DAA64867.1
Notes: Class A

CARB-17 family of beta-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

The study identifies bla CARB-17 as a novel class A beta-lactamase responsible for intrinsic resistance to penicillins in Vibrio parahaemolyticus.

Gene Information

Gene Name: blaCARB
Allele: blaCARB-17
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of penicillins
Confers Resistance To: PenicillinAmpicillinPiperacillin
Organisms Tested In: • Vibrio parahaemolyticus
• Escherichia coli
Geographic Location: Hong Kong|Shenzhen
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: KJ934265

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-34
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Sequence Accession: 48738
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-33
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S105
Sequence Accession: BK008903
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-32
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Sequence Accession: 48736
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-31
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Sequence Accession: 48735
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-30
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Sequence Accession: 48734
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-29
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S024
Sequence Accession: BK008905
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-28
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S023
Sequence Accession: BK008906
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-27
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Sequence Accession: 48730
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-26
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S014
Sequence Accession: BK008904
Notes: Class A;Alternative name CARB-39

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-25
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus M0605
Sequence Accession: BK008888
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-24
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: BK008907
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-17
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: KJ934265
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-43
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Sequence Accession: 48746
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-42
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Sequence Accession: 48745
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-41
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus TUMSAT_DE2_S2
Sequence Accession: BK008890
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-40
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus TUMSAT_DE1_S1
Sequence Accession: BK008889
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-33
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-33
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S105
Sequence Accession: BK008903.1
Protein Accession: DAA64867.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-35
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-35
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S141
Sequence Accession: BK008900.1
Protein Accession: DAA64864.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-34
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-34
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S115
Sequence Accession: BK008901.1
Protein Accession: DAA64865.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-34
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-34
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S115
Sequence Accession: BK008901.1
Protein Accession: DAA64865.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-34
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-34
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S115
Sequence Accession: BK008901.1
Protein Accession: DAA64865.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-24
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-24
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: BK008907.1
Protein Accession: DAA64871.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-24
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-24
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: BK008907.1
Protein Accession: DAA64871.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-24
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-24
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: BK008907.1
Protein Accession: DAA64871.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-25
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-25
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus M0605
Sequence Accession: BK008888.1
Protein Accession: DAA64852.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-25
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-25
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus M0605
Sequence Accession: BK008888.1
Protein Accession: DAA64852.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-25
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-25
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus M0605
Sequence Accession: BK008888.1
Protein Accession: DAA64852.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-26
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-26
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S174
Sequence Accession: BK008897.1
Protein Accession: DAA64861.1
Notes: Class A;Alternative name CARB-39

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-26
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-26
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S174
Sequence Accession: BK008897.1
Protein Accession: DAA64861.1
Notes: Class A;Alternative name CARB-39

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-26
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-26
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S174
Sequence Accession: BK008897.1
Protein Accession: DAA64861.1
Notes: Class A;Alternative name CARB-39

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-27
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-27
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S020
Sequence Accession: BK008896.1
Protein Accession: DAA64860.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-27
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-27
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S020
Sequence Accession: BK008896.1
Protein Accession: DAA64860.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-27
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-27
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S020
Sequence Accession: BK008896.1
Protein Accession: DAA64860.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-28
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-28
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S023
Sequence Accession: BK008906.1
Protein Accession: DAA64870.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-28
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-28
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S023
Sequence Accession: BK008906.1
Protein Accession: DAA64870.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-28
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-28
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S023
Sequence Accession: BK008906.1
Protein Accession: DAA64870.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-29
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-29
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S024
Sequence Accession: BK008905.1
Protein Accession: DAA64869.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-29
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-29
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S024
Sequence Accession: BK008905.1
Protein Accession: DAA64869.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-29
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-29
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S024
Sequence Accession: BK008905.1
Protein Accession: DAA64869.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-30
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-30
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S037
Sequence Accession: BK008893.1
Protein Accession: DAA64857.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-30
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-30
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S037
Sequence Accession: BK008893.1
Protein Accession: DAA64857.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-30
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-30
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S037
Sequence Accession: BK008893.1
Protein Accession: DAA64857.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-31
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-31
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S054
Sequence Accession: BK008895.1
Protein Accession: DAA64859.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-31
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-31
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S054
Sequence Accession: BK008895.1
Protein Accession: DAA64859.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-31
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-31
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S054
Sequence Accession: BK008895.1
Protein Accession: DAA64859.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-32
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-32
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S100
Sequence Accession: BK008892.1
Protein Accession: DAA64856.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-32
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-32
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S100
Sequence Accession: BK008892.1
Protein Accession: DAA64856.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-32
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-32
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S100
Sequence Accession: BK008892.1
Protein Accession: DAA64856.1
Notes: Class A

CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

PMID 25801555 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-33
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-33
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus S105
Sequence Accession: BK008903.1
Protein Accession: DAA64867.1
Notes: Class A

Complete Genome Sequences of a Clinical Isolate and an Environmental Isolate of Vibrio parahaemolyticus.

PMID 25814612 · 2015

Gene Information

Gene Name: blaCARB
Allele: blaCARB-21
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Sequence Accession: 48724
Notes: Class A, manually predicted phenotype

Defining a Core Genome Multilocus Sequence Typing Scheme for the Global Epidemiology of Vibrio parahaemolyticus.

PMID 28330888 · 2017

Gene Information

Gene Name: blaCARB
Allele: blaCARB-36
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: LHBD01000022
Notes: Class A, manually predicted phenotype

The history, genome and biology of NCTC 30: a non-pandemic Vibrio cholerae isolate from World War One.

PMID 30966987 · 2019

The study identifies a functional beta-lactamase gene, bla CARB-like, in the 102-year-old Vibrio cholerae isolate NCTC 30, which confers resistance to ampicillin.

Gene Information

Gene Name: blaCARB
Allele: blaCARB-like
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: Ampicillin
Organisms Tested In: • Vibrio cholerae
• Escherichia coli
Geographic Location: Egypt
Validation Method: cloning in E. coli + antibiotic sensitivity assay
Sequence Accession: AF409092

Non-typhoidal Salmonella blood stream infection in Kuwait: Clinical and microbiological characteristics.

PMID 30986214 · 2019

The study identified several AMR genes and mutations in non-typhoidal Salmonella isolates from Kuwait, including aac(6')-Iaa_1, aph(3'')-Ib_5, aph(3')-Ia_1, aph(6)-Id_1, blaCARB-2_1, blaTEM-1B_1, dfrA5_1, floR_2, sul2_2, tet(A)_6, tet(G)_2, and mutations in the gyrA gene. These genes and mutations were associated with resistance to various antibiotics such as aminoglycosides, beta-lactams, trimethoprim, chloramphenicol, sulfamethoxazole, tetracycline, and fluoroquinolones.

Gene Information

Gene Name: blaCARB
Allele: blaCARB-2_1
Encodes: Beta-lactam resistance
Source Database: Reslit
Mechanism: Carbapenem hydrolysis
Confers Resistance To: ImipenemMeropenem
Organisms Tested In: • Salmonella enterica subsp. enterica serovar Typhimurium
Geographic Location: Kuwait
Validation Method: Whole genome sequencing
Sequence Accession: PRJNA363099

Phenotypic and genotypic characterization of multi-drug-resistant Escherichia coli isolates harboring bla(CTX-M) group extended-spectrum beta-lactamases recovered from pediatric patients in Shenzhen, southern China.

PMID 31190921 · 2019

The study identified various bla CTX-M subtypes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-90, and others, as well as bla TEM, bla SHV, bla GES, bla CARB, bla NDM-1, bla KPC, and mcr-1, which contribute to multidrug resistance in E. coli isolates from pediatric patients in Shenzhen, China.

Gene Information

Gene Name: blaCARB
Allele: blaCARB
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of β-lactam antibiotics
Confers Resistance To: AmpicillinAmpicillin/sulbactam
Organisms Tested In: • Escherichia coli
Geographic Location: Shenzhen, southern China
Validation Method: PCR and sequencing

100

Determining antimicrobial susceptibility in Salmonella enterica serovar Typhimurium through whole genome sequencing: a comparison against multiple phenotypic susceptibility testing methods.

PMID 31266463 · 2019

The study identified various AMR genes and mutations in Salmonella enterica serovar Typhimurium, including aadA, strAB, blaTEM, blaCARB, floR, cmlA1, catA1, qnrB19, sul1, sul2, sul3, dfrA1, dfrA12, dfrA14, tetA, tetB, tetC, tetG, and mutations in gyrA. These genes and mutations were validated through whole genome sequencing and phenotypic ASTs.

Gene Information

Gene Name: blaCARB
Allele: blaCARB
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: Ampicillin
Organisms Tested In: • Salmonella enterica serovar Typhimurium
Geographic Location: UK
Validation Method: whole genome sequencing and phenotypic ASTs
Sequence Accession: PRJEB10999

101

Vibrios from the Norwegian marine environment: Characterization of associated antibiotic resistance and virulence genes.

PMID 32558371 · 2020

The study identified various antibiotic resistance genes in Vibrio isolates from the Norwegian marine environment, including beta-lactamases (blaCARB, blaampC, varG), tetracycline resistance genes (tet34, tet35), a multidrug efflux pump (adeF), a quinolone resistance gene (qnr), and a chloramphenicol resistance gene (catB-related).

Gene Information

Gene Name: blaCARB
Allele: blaCARB
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: confers resistance to beta-lactams
Confers Resistance To: Ampicillin
Organisms Tested In: • Vibrio alginolyticus
• Vibrio metschnikovii
• Vibrio antiquarius
Geographic Location: Norway
Validation Method: whole-genome sequencing
Sequence Accession: VHSL00000000|VHSN00000000|VHSK00000000|VHSM00000000|VHSO00000000|VHTC00000000|VHSI00000000|VHSR00000000|VHSS00000000|VHST00000000|VHSV00000000|VHSX00000000|VHSW00000000|VHSU00000000|VHSQ00000000|VHSY00000000|VHSP00000000|VMQP00000000

102

Impact of RBX2660 on the microbiome and resistome in patients with recurrent Clostridium difficile infection

PMID 32862830 · 2020

RBX2660 introduced antibiotic-resistant organisms (AROs) with various resistance genes, including AmpC, TEM-1, CARB, and CTX-M-14, which conferred resistance to multiple antibiotics.

Gene Information

Gene Name: blaCARB
Allele: blaCARB-17
Encodes: carbapenemase
Source Database: Reslit
Confers Resistance To: ImipenemMeropenem
Organisms Tested In: • Escherichia coli
Geographic Location: USA|Canada
Validation Method: antibiotic susceptibility testing
Sequence Accession: NCBI BioProject PRJNA606075|NCBI BioProject PRJNA606074

103

Impact of RBX2660 on the microbiome and resistome in patients with recurrent Clostridium difficile infection

PMID 32862830 · 2020

RBX2660 introduced antibiotic-resistant organisms (AROs) with various resistance genes, including AmpC, TEM-1, CARB, and CTX-M-14, which conferred resistance to multiple antibiotics.

Gene Information

Gene Name: blaCARB
Allele: blaCARB-19
Encodes: carbapenemase
Source Database: Reslit
Confers Resistance To: ImipenemMeropenem
Organisms Tested In: • Escherichia coli
Geographic Location: USA|Canada
Validation Method: antibiotic susceptibility testing
Sequence Accession: NCBI BioProject PRJNA606075|NCBI BioProject PRJNA606074

104

Impact of RBX2660 on the microbiome and resistome in patients with recurrent Clostridium difficile infection

PMID 32862830 · 2020

RBX2660 introduced antibiotic-resistant organisms (AROs) with various resistance genes, including AmpC, TEM-1, CARB, and CTX-M-14, which conferred resistance to multiple antibiotics.

Gene Information

Gene Name: blaCARB
Allele: blaCARB-20
Encodes: carbapenemase
Source Database: Reslit
Confers Resistance To: ImipenemMeropenem
Organisms Tested In: • Escherichia coli
Geographic Location: USA|Canada
Validation Method: antibiotic susceptibility testing
Sequence Accession: NCBI BioProject PRJNA606075|NCBI BioProject PRJNA606074

105

Rapid and Visual Detection of Vibrio parahaemolyticus in Aquatic Foods Using bla(CARB-17) Gene-Based Loop-Mediated Isothermal Amplification with Lateral Flow Dipstick (LAMP-LFD).

PMID 34489378 · 2021

The study developed a LAMP-LFD assay targeting the bla(CARB-17) gene, which is an intrinsic beta-lactamase gene specific to Vibrio parahaemolyticus, providing a rapid and specific detection method for this pathogen in aquatic foods.

Gene Information

Gene Name: blaCARB
Allele: bla(CARB-17)
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: intrinsic resistance to penicillins
Confers Resistance To: Penicillin
Organisms Tested In: • Vibrio parahaemolyticus
Geographic Location: China
Validation Method: LAMP-LFD assay with specific detection of V. parahaemolyticus ATCC 17802
Sequence Accession: KJ934265

106

Molluscs-A ticking microbial bomb.

PMID 36699600 · 2022

The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.

Gene Information

Gene Name: blaCARB
Allele: blaCARB-44
Encodes: beta-lactam resistance
Source Database: Reslit
Confers Resistance To: Ampicillin
Organisms Tested In: • Vibrio spp.
Geographic Location: Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea
Validation Method: disk diffusion

107

Molluscs-A ticking microbial bomb.

PMID 36699600 · 2022

Gene Information

Gene Name: blaCARB
Allele: blaCARB-41
Encodes: beta-lactam resistance
Source Database: Reslit
Confers Resistance To: Ampicillin
Organisms Tested In: • Vibrio spp.
Geographic Location: Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea
Validation Method: disk diffusion

108

Molluscs-A ticking microbial bomb.

PMID 36699600 · 2022

Gene Information

Gene Name: blaCARB
Allele: blaCARB-33
Encodes: beta-lactam resistance
Source Database: Reslit
Confers Resistance To: Ampicillin
Organisms Tested In: • Vibrio spp.
Geographic Location: Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea
Validation Method: disk diffusion

109

Molluscs-A ticking microbial bomb.

PMID 36699600 · 2022

Gene Information

Gene Name: blaCARB
Allele: blaCARB-29
Encodes: beta-lactam resistance
Source Database: Reslit
Confers Resistance To: Ampicillin
Organisms Tested In: • Vibrio spp.
Geographic Location: Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea
Validation Method: disk diffusion

110

Molluscs-A ticking microbial bomb.

PMID 36699600 · 2022

Gene Information

Gene Name: blaCARB
Allele: blaCARB-23
Encodes: beta-lactam resistance
Source Database: Reslit
Confers Resistance To: Ampicillin
Organisms Tested In: • Vibrio spp.
Geographic Location: Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea
Validation Method: disk diffusion

111

Molluscs-A ticking microbial bomb.

PMID 36699600 · 2022

Gene Information

Gene Name: blaCARB
Allele: blaCARB-21
Encodes: beta-lactam resistance
Source Database: Reslit
Confers Resistance To: Ampicillin
Organisms Tested In: • Vibrio spp.
Geographic Location: Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea
Validation Method: disk diffusion

112

Molluscs-A ticking microbial bomb.

PMID 36699600 · 2022

Gene Information

Gene Name: blaCARB
Allele: blaCARB-19
Encodes: beta-lactam resistance
Source Database: Reslit
Confers Resistance To: Ampicillin
Organisms Tested In: • Vibrio spp.
Geographic Location: Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea
Validation Method: disk diffusion

113

Molluscs-A ticking microbial bomb.

PMID 36699600 · 2022

Gene Information

Gene Name: blaCARB
Allele: blaCARB-18
Encodes: beta-lactam resistance
Source Database: Reslit
Confers Resistance To: Ampicillin
Organisms Tested In: • Vibrio spp.
Geographic Location: Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea
Validation Method: disk diffusion

114

Incidence, genetic diversity, and antimicrobial resistance profiles of Vibrio parahaemolyticus in seafood in Bangkok and eastern Thailand.

PMID 37193031 · 2023

The study identified several antimicrobial resistance genes in Vibrio parahaemolyticus isolates from seafood in Bangkok and eastern Thailand, including blaCARB, tet(34), tet(35), qnrC, dfrA6, and blaCTX-M-55, which confer resistance to various antibiotics such as ampicillin, amoxicillin, piperacillin, tetracycline, doxycycline, ciprofloxacin, and trimethoprim.

Gene Information

Gene Name: blaCARB
Allele: blaCARB
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: AmpicillinAmoxicillinPiperacillin
Organisms Tested In: • Vibrio parahaemolyticus
Geographic Location: Bangkok|eastern Thailand|Thailand
Validation Method: genome analysis
Sequence Accession: GCA_000196095.1|PRJNA859558

115

Prevalence and antimicrobial resistance profiles of Vibrio spp. and Enterococcus spp. in retail shrimp in Northern California.

PMID 37455729 · 2023

The study identified 27 unique antimicrobial resistance genes (ARGs) in Vibrio isolates, including qnrVC6, dfrA31, dfrA6, and qnrVC1, which conferred resistance to various antibiotics such as cephalosporins, chloramphenicol, gentamicin, and tetracycline.

Gene Information

Gene Name: blaCARB
Allele: blaCARB
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: hydrolyzes beta-lactam antibiotics
Confers Resistance To: AmpicillinPenicillin
Organisms Tested In: • Vibrio
Geographic Location: Northern California|northern California|California
Validation Method: whole genome sequencing

116

Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.

PMID 37549252 · 2023

The study identified various AMR genes in multidrug-resistant Gram-negative pathogens, highlighting the prevalence of bla CTX-M-15, bla CMY-42, bla NDM-5, aadA, bla TEM-1B, bla OXA-232, bla NDM-1, rmtB, rmtC, bla VEB, bla VIM-2, aph(3'), strA/B, bla OXA-23, aph (3′), catB, dfrB, bla VIM-2, fosA, oqxA, oqxB, bla OXA-23, bla CARB, bla OXA-91, bla OXA-51, bla PAO, bla SHV, aph (3′)-Ib, aph (6)-Id, mphE, msrE, ermB, mphA, aadA, rmtB, qnrB, dfrA, sul1, sul2, and fosA7.

Gene Information

Gene Name: blaCARB
Allele: blaCARB
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: Carbapenem
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: India
Validation Method: whole-genome sequencing
Sequence Accession: PRJNA925003|INRP000050|PXD039154

117

Serovars, Virulence and Antimicrobial Resistance Genes of Non-Typhoidal Salmonella Strains from Dairy Systems in Mexico.

PMID 38136696 · 2023

Gene Information

Gene Name: blaCARB
Allele: blaCARB
Encodes: carbapenemase
Source Database: Reslit
Mechanism: class 1 integron-borne carbapenem resistance
Confers Resistance To: Carbapenem
Organisms Tested In: • Salmonella enterica
Validation Method: genomic characterization

118

Persistence of Marine Bacterial Plasmid in the House Fly (Musca domestica): Marine-Derived Antimicrobial Resistance Genes Have a Chance of Invading the Human Environment.

PMID 38191744 · 2024

The study shows that the marine bacterial plasmid pAQU1, carrying several antimicrobial resistance genes, can persist in the house fly intestine for up to 5 days, potentially facilitating the transmission of marine-derived antimicrobial resistance genes to the human environment.

Gene Information

Gene Name: blaCARB
Allele: blaCARB
Encodes: beta-lactam resistance
Source Database: Reslit
Confers Resistance To: Beta-lactams
Organisms Tested In: • Photobacterium damselae subsp. damselae
• Escherichia coli
Validation Method: plasmid copy number quantification

119

Genomic mining of Vibrio parahaemolyticus highlights prevalence of antimicrobial resistance genes and new genetic markers associated with AHPND and tdh + /trh + genotypes.

PMID 38355437 · 2024

The study identified several antimicrobial resistance genes in Vibrio parahaemolyticus strains, including bla CARB-21, bla CARB-23, tet(B), and dfrA6, which confer resistance to beta-lactams, tetracycline, and trimethoprim-sulfamethoxazole.

Gene Information

Gene Name: blaCARB
Allele: blaCARB-21
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: AmpicillinPiperacillin
Organisms Tested In: • Vibrio parahaemolyticus
Geographic Location: Mexico|Thailand|China
Validation Method: phenotypic antibiotic susceptibility testing and genomic ARG screening
Sequence Accession: CP133891-CP133899|JAVKPG000000000|CP133900-CP133905

120

Genomic mining of Vibrio parahaemolyticus highlights prevalence of antimicrobial resistance genes and new genetic markers associated with AHPND and tdh + /trh + genotypes.

PMID 38355437 · 2024

Gene Information

Gene Name: blaCARB
Allele: blaCARB-23
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: AmpicillinPiperacillin
Organisms Tested In: • Vibrio parahaemolyticus
Geographic Location: Mexico|Thailand|China
Validation Method: phenotypic antibiotic susceptibility testing and genomic ARG screening
Sequence Accession: CP133891-CP133899|JAVKPG000000000|CP133900-CP133905

121

Antimicrobial susceptibility profile and molecular characterization of Vibrio parahaemolyticus strains isolated from imported shrimps.

PMID 38832768 · 2024

The study identified several AMR genes in V. parahaemolyticus isolates from imported shrimps, including aph(3"-Ib, aph(6)-Id, sul2, tet(59), floR, bla CARB-26, bla CARB-31, bla CARB-41, bla OXA-SHE, and qnrA5, which confer resistance to various antibiotics such as streptomycin, trimethoprim-sulfamethoxazole, tetracycline, chloramphenicol, and others.

Gene Information

Gene Name: blaCARB
Allele: blaCARB-41
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: coding for beta-lactamase
Confers Resistance To: CephalothinCeftazidimeCefotaxime
Organisms Tested In: • Vibrio parahaemolyticus
Geographic Location: France|Ecuador|Vietnam|India|Madagascar|Nigeria
Validation Method: genome sequencing
Sequence Accession: CP079805|CP079806|CP079807|CP079808|CP079809|CP079810|CP079811

122

Antimicrobial susceptibility profile and molecular characterization of Vibrio parahaemolyticus strains isolated from imported shrimps.

PMID 38832768 · 2024

Gene Information

Gene Name: blaCARB
Allele: blaCARB-31
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: coding for beta-lactamase
Confers Resistance To: CephalothinCeftazidimeCefotaxime
Organisms Tested In: • Vibrio parahaemolyticus
Geographic Location: France|Ecuador|Vietnam|India|Madagascar|Nigeria
Validation Method: genome sequencing
Sequence Accession: CP079805|CP079806|CP079807|CP079808|CP079809|CP079810|CP079811

123

Antimicrobial susceptibility profile and molecular characterization of Vibrio parahaemolyticus strains isolated from imported shrimps.

PMID 38832768 · 2024

Gene Information

Gene Name: blaCARB
Allele: blaCARB-26
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: coding for beta-lactamase
Confers Resistance To: CephalothinCeftazidimeCefotaxime
Organisms Tested In: • Vibrio parahaemolyticus
Geographic Location: France|Ecuador|Vietnam|India|Madagascar|Nigeria
Validation Method: genome sequencing
Sequence Accession: CP079805|CP079806|CP079807|CP079808|CP079809|CP079810|CP079811

124

Antimicrobial resistance, virulence factors and phylogenetic profiles of Vibrio parahaemolyticus in the eastern coast of Shenzhen.

PMID 39588110 · 2024

The study identified several antimicrobial resistance genes in Vibrio parahaemolyticus isolates from Shenzhen, including blaCARB, tet(34), tet(35), qnrVC6, sul2, aph(6)-Id, floR, cat, and blaCTX-M-14. These genes conferred resistance to various antibiotics such as ampicillin, tetracycline, fluoroquinolones, sulfonamides, aminoglycosides, chloramphenicol, and beta-lactams.

Gene Information

Gene Name: blaCARB
Allele: blaCARB
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: AmpicillinAmoxicillinPiperacillin
Organisms Tested In: • Vibrio parahaemolyticus
Geographic Location: Shenzhen|Dapeng
Validation Method: whole genome sequencing and ResFinder analysis

125

Genomic insights into bacteriophages: a new frontier in AMR detection and phage therapy.

PMID 40720171 · 2025

The paper discusses the identification of various AMR genes in Acinetobacter baumannii and other pathogens, highlighting their role in resistance to multiple antibiotics and the potential of phage therapy as an alternative treatment.

Gene Information

Gene Name: blaCARB
Allele: blaCARB
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: Carbapenem
Organisms Tested In: • Acinetobacter baumannii
Validation Method: genome sequencing

126

PMID unpublished

Gene Information

Gene Name: blaCARB
Allele: blaCARB-48
Encodes: CARB beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus VPTS-2009
Sequence Accession: NG_050604.1
Protein Accession: WP_025577435.1
Notes: ARO:3005582

127

PMID unpublished

Gene Information

Gene Name: blaCARB
Allele: blaCARB-47
Encodes: CARB beta-lactamase
Source Database: ResFinder Database
Mechanism: antibiotic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus NIHCB0757
Sequence Accession: NG_050564.1
Protein Accession: WP_031841337.1
Notes: ARO:3005581

128

PMID unpublished

Gene Information

Gene Name: blaCARB
Allele: blaCARB-48
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Sequence Accession: NG050604
Notes: Class A, manually predicted phenotype

129

PMID unpublished

Gene Information

Gene Name: blaCARB
Allele: blaCARB-47
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Sequence Accession: NG050564
Notes: Class A, manually predicted phenotype

130

PMID unpublished

Gene Information

Gene Name: blaCARB
Allele: blaCARB-46
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Sequence Accession: 48749
Notes: Class A, manually predicted phenotype

131

PMID unpublished

Gene Information

Gene Name: blaCARB
Allele: blaCARB-20
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Sequence Accession: 54946
Notes: Class A

132

PMID unpublished

Gene Information

Gene Name: blaCARB
Allele: blaCARB-19
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: KJ934267
Notes: Class A

133

PMID unpublished

Gene Information

Gene Name: blaCARB
Allele: blaCARB-18
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: KJ934266
Notes: Class A;Alternative name CARB-37

134

PMID unpublished

Gene Information

Gene Name: blaCARB
Allele: blaCARB-48
Encodes: CARB beta-lactamase
Source Database: ResFinder Database
Mechanism: antibiotic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus VPTS-2009
Sequence Accession: NG_050604.1
Protein Accession: WP_025577435.1
Notes: ARO:3005582

135

PMID unpublished

Gene Information

Gene Name: blaCARB
Allele: blaCARB-47
Encodes: CARB beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus NIHCB0757
Sequence Accession: NG_050564.1
Protein Accession: WP_031841337.1
Notes: ARO:3005581

136

PMID N/A

Gene Information

Gene Name: blaCARB
Allele: blaCARB-30
Encodes: CARB beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Vibrio parahaemolyticus S037
Sequence Accession: NG_048734.1
Protein Accession: WP_005498292.1
Notes: ARO:3005566

137

PMID N/A

Gene Information

Gene Name: blaCARB
Allele: blaCARB-41
Encodes: CARB beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Vibrio parahaemolyticus TUMSAT_DE2_S2
Sequence Accession: NG_048744.1
Protein Accession: WP_025788060.1
Notes: ARO:3005575

138

PMID N/A

Gene Information

Gene Name: blaCARB
Allele: blaCARB-22
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-22, CARB beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus RIMD 2210633
Sequence Accession: BA000032.2
Protein Accession: BAC61820.1
Notes: Class A, ARO:3003151

139

PMID N/A

Gene Information

Gene Name: blaCARB
Allele: blaCARB-22
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-22
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus RIMD 2210633
Sequence Accession: BA000032.2
Protein Accession: BAC61820.1
Notes: Class A

140

PMID N/A

Gene Information

Gene Name: blaCARB
Allele: blaCARB-22
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-22
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus RIMD 2210633
Sequence Accession: BA000032.2
Protein Accession: BAC61820.1
Notes: Class A

141

PMID N/A

Gene Information

Gene Name: blaCARB
Allele: blaCARB-19
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-19, CARB beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: KJ934267.1
Protein Accession: AIL92328.1
Notes: Class A, ARO:3003175

142

PMID N/A

Gene Information

Gene Name: blaCARB
Allele: blaCARB-19
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-19
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: KJ934267.1
Protein Accession: AIL92328.1
Notes: Class A

143

PMID N/A

Gene Information

Gene Name: blaCARB
Allele: blaCARB-19
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-19
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: KJ934267.1
Protein Accession: AIL92328.1
Notes: Class A

144

PMID N/A

Gene Information

Gene Name: blaCARB
Allele: blaCARB-18
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-18, CARB beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: KJ934266.1
Protein Accession: AIL92327.1
Notes: Class A;Alternative name CARB-37, ARO:3003174

145

PMID N/A

Gene Information

Gene Name: blaCARB
Allele: blaCARB-18
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-18
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: KJ934266.1
Protein Accession: AIL92327.1
Notes: Class A;Alternative name CARB-37

146

PMID N/A

Gene Information

Gene Name: blaCARB
Allele: blaCARB-18
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-18
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Vibrio parahaemolyticus
Sequence Accession: KJ934266.1
Protein Accession: AIL92327.1
Notes: Class A;Alternative name CARB-37

147

PMID N/A

Gene Information

Gene Name: blaCARB
Allele: blaCARB-47
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-47
Source Database: Reference Gene Catalog
Confers Resistance To: BETA-LACTAM
Organisms Tested In: • Vibrio parahaemolyticus NIHCB0757
Sequence Accession: AVPX01000003.1

148

PMID N/A

Gene Information

Gene Name: blaCARB
Allele: blaCARB-48
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-48
Source Database: Reference Gene Catalog
Confers Resistance To: BETA-LACTAM
Organisms Tested In: • Vibrio parahaemolyticus VPTS-2009
Sequence Accession: JDFM01000025.1

149

PMID N/A

Gene Information

Gene Name: blaCARB
Allele: blaCARB-56
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-56
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: BETA-LACTAM
Organisms Tested In: • Vibrio alginolyticus
Sequence Accession: MZ092819.1
Protein Accession: QVO43826.1
Notes: ARO:3007803

150

PMID N/A

Gene Information

Gene Name: blaCARB
Allele: blaCARB-56
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-56, CARB beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: BETA-LACTAM
Organisms Tested In: • Vibrio alginolyticus
Sequence Accession: MZ092819.1
Protein Accession: QVO43826.1
Notes: ARO:3007803

151

PMID N/A

Gene Information

Gene Name: blaCARB
Allele: blaCARB-57
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-57
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: BETA-LACTAM
Organisms Tested In: • Vibrio diabolicus
Sequence Accession: MZ092820.1
Protein Accession: QVO43827.1
Notes: ARO:3007836

152

PMID N/A

Gene Information

Gene Name: blaCARB
Allele: blaCARB-57
Encodes: carbenicillin-hydrolyzing class A beta-lactamase CARB-57, CARB beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: BETA-LACTAM
Organisms Tested In: • Vibrio diabolicus
Sequence Accession: MZ092820.1
Protein Accession: QVO43827.1
Notes: ARO:3007836