Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
CMY-2 family cephalosporin-hydrolyzing class C beta-lactamase CFE-1
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaCFE-1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | TICARCILLIN, AMOXICILLIN +13 | Escherichia coli |
| England, Italy |
| 2004, 2017, 2022, 2024 |
| AB107899 |
| BAC76072.1 |
| bla_CFE-1 | Reslit | 1 | Cefoxitin, Cephalothin +5 | Escherichia coli +1 | Japan | 2004 | AB107899 | - |
| blaCFE | Reslit | 2 | Beta-lactams, Ceftazidime +1 | Klebsiella pneumoniae ATCC BAA-2146 +1 | Greece, Finland | 2016, 2023 | - | - |
| blaCFE-2 | Card DatabaseReference Gene Catalog | 2 | CEPHALOSPORIN | Citrobacter freundii | - | 2018 | MF543129.1 | AWX35642.1 |
| blaCMY-209 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter freundii | - | - | PV075200.1 | XOU30664.1 |
| blaCMY-213 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter sp. | - | - | PV075204.1 | XOU30668.1 |
| blaCMY-212 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter freundii | - | - | PV075203.1 | XOU30667.1 |
| blaCMY-210 | Reference Gene Catalog | 1 | CEPHALOSPORIN | Citrobacter freundii | - | - | PV075201.1 | XOU30665.1 |
CFE-1, a novel plasmid-encoded AmpC beta-lactamase with an ampR gene originating from Citrobacter freundii.
CFE-1, a novel plasmid-encoded AmpC beta-lactamase with an ampR gene originating from Citrobacter freundii.
CFE-1, a novel plasmid-encoded AmpC beta-lactamase with an ampR gene originating from Citrobacter freundii.
CFE-1, a novel plasmid-encoded AmpC beta-lactamase with an ampR gene originating from Citrobacter freundii.
CFE-1, a novel plasmid-encoded AmpC beta-lactamase with an ampR gene originating from Citrobacter freundii.
The study identifies a novel plasmid-encoded AmpC beta-lactamase, CFE-1, which confers resistance to various beta-lactam antibiotics. The gene is derived from Citrobacter freundii and includes an ampR regulatory gene.
Streaming algorithms for identification of pathogens and antibiotic resistance potential from real-time MinION(TM) sequencing.
The study presents a real-time analysis framework for MinION sequencing data, demonstrating the ability to identify pathogens and antibiotic resistance genes within a few hours of sequencing. Key resistance genes identified include blaSHV, mphA, strA, strB, blaTEM, sul2, blaOXA, aac3, aac6, blaCMY, blaCFE, blaLAT, blaBIL, QnrB, aadA, oqxA, tetA, oqxB, rmtC, sul1, sul3, fosA, blaNDM, oqxA, blaSHV, oqxB, aadB, sul1, sul3, blaOXA, blaOKP, fosA, blaSHV, blaOKP, blaLEN, oqxA, and oqxB.
Role of AmpR in the High Expression of the Plasmid-Encoded AmpC beta-lactamase CFE-1.
The study identifies a point mutation in AmpR (Asp135Ala) that leads to constitutive high-level expression of the plasmid-encoded AmpC beta-lactamase CFE-1, resulting in high resistance to cephalosporins.
Identification of CFE-2, a new plasmid-encoded AmpC β-lactamase from a clinical isolate of Citrobacter freundii.
Identification of CFE-2, a new plasmid-encoded AmpC β-lactamase from a clinical isolate of Citrobacter freundii.
HAM-ART: An optimised culture-free Hi-C metagenomics pipeline for tracking antimicrobial resistance genes in complex microbial communities.
The study identified various AMR genes, including aadA1, aadA2, blaCFE-1, cmlA1, dfrA12, mdf(A), sul3, tet(34), and lnu(A), in pig fecal microbiomes. Notably, the lnu(A) gene was exclusively found in conventional farms and associated with Lactobacillus species.
Genomic epidemiology of nosocomial carbapenemase-producing Citrobacter freundii in sewerage systems in the Helsinki metropolitan area, Finland.
The study identified bla KPC-2 and bla VIM-1 carbapenemase genes, along with various other AMR genes such as aac(6′)-If, aph(6)-Id, aac(3)-IIa, aadA1, dfrA1, sul2, sat2, qnrB, cmlA5, bla OXA-9, bla CMY-79, bla CMY-116, bla TEM-1A, bla CMY-117, bla OXA-10, bla CFE, bla CMY-100, aac(6′)-Ib, aadA2, sul1, qnrS1, qnrB9, mph(E), msr(E), aac(6′)-Iic, and dfrA16 in carbapenemase-producing Citrobacter freundii isolates from hospital environments and municipal wastewater in Finland.
Occurrence and genomic characterization of antimicrobial-resistant and potential pathogenic Escherichia coli from Italian artisanal food productions of animal origin.
The study identified multiple antimicrobial resistance (AMR) genes in Escherichia coli isolates from Italian artisanal food products, including beta-lactamases, aminoglycoside-modifying enzymes, trimethoprim resistance genes, macrolide resistance genes, quinolone resistance proteins, sulfonamide resistance proteins, and tetracycline resistance genes. These genes were primarily carried on plasmids and contributed to multidrug resistance.
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