Browse AMR Genes

Explore antimicrobial resistance genes from the literature

blaCIA

extended-spectrum class A beta-lactamase CIA-4, CIA beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaCIA

Browse AMR rules for blaCIA

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: cloning in E. coli BL21 and determination of MICs
Drug Classes: CEPHALOSPORIN, Penicillin, Cephalosporin, Carbapenem, Beta-lactam
Organisms: Chryseobacterium indologenes, Chryseobacterium indologenes NBRC 14944, Chryseobacterium indologenes ATCC 29897, Escherichia coli BL21, Chryseobacterium gallinarum MGC42
Geographic Location: Brazil, India, Shanghai, China
Alleles: 5
Papers: 4
Databases: Card DatabaseReference Gene CatalogReslit

Allele Variants5

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
blaCIA-4	Card DatabaseReference Gene CatalogReslit	3	CEPHALOSPORIN, Beta-lactam	Chryseobacterium indologenes +1	India	2012, 2022	AB674568.1

Papers4

1

Characterization of CIA-1, an Ambler class A extended-spectrum β-lactamase from Chryseobacterium indologenes.

PMID 22083470 · 2012

Gene Information

Gene Name: blaCIA
Allele: blaCIA-4
Encodes: extended-spectrum class A beta-lactamase CIA-4, CIA beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Chryseobacterium indologenes
Sequence Accession: AB674568.1
Protein Accession: BAL40895.1
Notes: ARO:3004771

2

Characterization of CIA-1, an Ambler class A extended-spectrum β-lactamase from Chryseobacterium indologenes.

PMID 22083470 · 2012

Gene Information

Gene Name: blaCIA
Allele: blaCIA-1
Encodes: extended-spectrum class A beta-lactamase CIA-1
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Chryseobacterium indologenes NBRC 14944
Sequence Accession: AB639753.1
Protein Accession: BAL40892.1
Notes: ARO:3004768

3

Characterization of CIA-1, an Ambler class A extended-spectrum β-lactamase from Chryseobacterium indologenes.

PMID 22083470 · 2012

Gene Information

Gene Name: blaCIA
Allele: blaCIA-1
Encodes: extended-spectrum class A beta-lactamase CIA-1, CIA beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Chryseobacterium indologenes NBRC 14944
Sequence Accession: AB639753.1
Protein Accession: BAL40892.1
Notes: ARO:3004768

4

Characterization of CIA-1, an Ambler class A extended-spectrum beta-lactamase from Chryseobacterium indologenes.

PMID 22083470 · 2012

The study characterizes CIA-1, a novel Ambler class A extended-spectrum beta-lactamase from Chryseobacterium indologenes, which confers resistance to penicillins, cephalosporins, and carbapenems.

Gene Information

Gene Name: blaCIA
Allele: blaCIA-1
Encodes: Ambler class A extended-spectrum beta-lactamase
Source Database: Reslit
Confers Resistance To: PenicillinCephalosporinCarbapenem
Organisms Tested In: • Chryseobacterium indologenes ATCC 29897
• Escherichia coli BL21
Validation Method: cloning in E. coli BL21 and determination of MICs
Sequence Accession: AB639753|AB674566|AB674567|AB674568

5

Characterization of CIA-1, an Ambler class A extended-spectrum β-lactamase from Chryseobacterium indologenes.

PMID 22083470 · 2012

Gene Information

Gene Name: blaCIA
Allele: blaCIA-2
Encodes: extended-spectrum class A beta-lactamase CIA-2
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Chryseobacterium indologenes
Sequence Accession: AB674566.1
Protein Accession: BAL40893.1
Notes: ARO:3004769

6

Characterization of CIA-1, an Ambler class A extended-spectrum β-lactamase from Chryseobacterium indologenes.

PMID 22083470 · 2012

Gene Information

Gene Name: blaCIA
Allele: blaCIA-2
Encodes: extended-spectrum class A beta-lactamase CIA-2, CIA beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Chryseobacterium indologenes
Sequence Accession: AB674566.1
Protein Accession: BAL40893.1
Notes: ARO:3004769

7

Characterization of CIA-1, an Ambler class A extended-spectrum β-lactamase from Chryseobacterium indologenes.

PMID 22083470 · 2012

Gene Information

Gene Name: blaCIA
Allele: blaCIA-3
Encodes: extended-spectrum class A beta-lactamase CIA-3
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Chryseobacterium indologenes
Sequence Accession: AB674567.1
Protein Accession: BAL40894.1
Notes: ARO:3004770

8

Characterization of CIA-1, an Ambler class A extended-spectrum β-lactamase from Chryseobacterium indologenes.

PMID 22083470 · 2012

Gene Information

Gene Name: blaCIA
Allele: blaCIA-3
Encodes: extended-spectrum class A beta-lactamase CIA-3, CIA beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Chryseobacterium indologenes
Sequence Accession: AB674567.1
Protein Accession: BAL40894.1
Notes: ARO:3004770

9

Characterization of CIA-1, an Ambler class A extended-spectrum β-lactamase from Chryseobacterium indologenes.

PMID 22083470 · 2012

Gene Information

Gene Name: blaCIA
Allele: blaCIA-4
Encodes: extended-spectrum class A beta-lactamase CIA-4
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Chryseobacterium indologenes
Sequence Accession: AB674568.1
Protein Accession: BAL40895.1
Notes: ARO:3004771

10

Clinical and molecular characteristics of Chryseobacterium indologenes isolates at a teaching hospital in Shanghai, China.

PMID 33987366 · 2021

The study identified bla IND and bla CIA genes contributing to beta-lactam resistance and GyrA mutations leading to quinolone resistance in Chryseobacterium indologenes isolates.

Gene Information

Gene Name: blaCIA
Allele: blaCIA
Encodes: class A beta-lactamase
Source Database: Reslit
Confers Resistance To: CephalosporinCarbapenem
Organisms Tested In: • Chryseobacterium indologenes
Geographic Location: Shanghai, China
Validation Method: PCR and sequencing
Sequence Accession: LN681561

11

Characterization and Comparative Genomic Analysis of a Highly Colistin-Resistant Chryseobacterium gallinarum: a Rare, Uncommon Pathogen.

PMID 35909954 · 2022

The study identifies mutations in pmrB (M384T) and lpxD (I66V) as potential contributors to colistin resistance in Chryseobacterium gallinarum MGC42.

Gene Information

Gene Name: blaCIA
Allele: blaCIA-4
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: Beta-lactam
Organisms Tested In: • Chryseobacterium gallinarum MGC42
Geographic Location: India
Validation Method: sequence analysis and structural features
Sequence Accession: CP099005|GCA_023604885.1

12

Whole genome sequencing of the multidrug-resistant Chryseobacterium indologenes isolated from a patient in Brazil.

PMID 35966843 · 2022

The study identified multiple antibiotic resistance genes and mutations in a multidrug-resistant Chryseobacterium indologenes strain, including beta-lactamases, quinolone resistance genes, tetracycline resistance genes, and efflux pumps, contributing to resistance against various antibiotics.

Gene Information

Gene Name: blaCIA
Allele: blaCIA-3
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: beta-lactam hydrolysis
Confers Resistance To: CarbapenemCephalosporin
Organisms Tested In: • Chryseobacterium indologenes
Geographic Location: Brazil
Validation Method: whole-genome sequencing and phenotypic analysis
Sequence Accession: PRJNA830910