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Explore antimicrobial resistance genes from the literature

blaCKO

MAL/CKO family class A beta-lactamase CKO-1

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaCKO

Browse AMR rules for blaCKO

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic inactivation
Validation Method: metagenomic sequencing and comparison with culture results
Drug Classes: TICARCILLIN, AMOXICILLIN, AMPICILLIN+CLAVULANIC ACID, AMPICILLIN, BETA-LACTAM, AMOXICILLIN+CLAVULANIC ACID, PIPERACILLIN+TAZOBACTAM, PIPERACILLIN, Beta-lactams, Ceftazidime, Cefotaxime, CEPHALOTHIN, TICARCILLIN+CLAVULANIC ACID
Organisms: Citrobacter koseri, Enterobacter quasiroggenkampii, Enterobacter hormachei, Klebsiella quasipneumoniae, Klebsiella variicola, Proteus terrae, Proteus faecis
Geographic Location: Edo state, Nigeria, Europe|United Kingdom
Alleles: 6
Papers: 4
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants6

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
blaCKO-1	Card DatabaseReference Gene CatalogResFinder Database	4	TICARCILLIN, AMOXICILLIN +6	Citrobacter koseri	-	2006	AF477396.1

Papers4

1

Characterization of the chromosomal class A beta-lactamase CKO from Citrobacter koseri.

PMID 16445758 · 2006

Gene Information

Gene Name: blaCKO
Allele: blaCKO-1
Encodes: MAL/CKO family class A beta-lactamase CKO-1
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINAMPICILLIN+CLAVULANIC ACIDAMPICILLINBETA-LACTAMAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Citrobacter koseri
Sequence Accession: AF477396.1
Protein Accession: AAL85333.1
Notes: Chromosomal class A beta-lactamase

2

Characterization of the chromosomal class A beta-lactamase CKO from Citrobacter koseri.

PMID 16445758 · 2006

Gene Information

Gene Name: blaCKO
Allele: blaCKO-1
Encodes: MAL/CKO family class A beta-lactamase CKO-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINAMPICILLIN+CLAVULANIC ACIDAMPICILLINBETA-LACTAMAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Citrobacter koseri
Sequence Accession: AF477396.1
Protein Accession: AAL85333.1
Notes: Chromosomal class A beta-lactamase

3

Characterization of the chromosomal class A beta-lactamase CKO from Citrobacter koseri.

PMID 16445758 · 2006

Gene Information

Gene Name: blaCKO
Allele: blaCKO-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINAMPICILLIN+CLAVULANIC ACIDAMPICILLINAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Citrobacter koseri
Sequence Accession: AF477396
Notes: Chromosomal class A beta-lactamase

4

Characterization of the chromosomal class A beta-lactamase CKO from Citrobacter koseri.

PMID 16445758 · 2006

Gene Information

Gene Name: blaCKO
Allele: blaCKO-1
Encodes: MAL/CKO family class A beta-lactamase CKO-1, CKO beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: TICARCILLINAMOXICILLINAMPICILLIN+CLAVULANIC ACIDAMPICILLINBETA-LACTAMAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Citrobacter koseri
Sequence Accession: AF477396.1
Protein Accession: AAL85333.1
Notes: Chromosomal class A beta-lactamase, ARO:3004773

5

Evaluating the potential for respiratory metagenomics to improve treatment of secondary infection and detection of nosocomial transmission on expanded COVID-19 intensive care units.

PMID 34784976 · 2021

The study evaluated the use of respiratory metagenomics to detect antimicrobial resistance genes and improve treatment of secondary infections in ICU patients. It identified several beta-lactam resistance genes, macrolide resistance genes, and sulfonamide resistance genes in various bacterial species.

Gene Information

Gene Name: blaCKO
Allele: blaCKO
Encodes: Beta-lactamase
Source Database: Reslit
Confers Resistance To: Beta-lactams
Organisms Tested In: • Citrobacter koseri
Geographic Location: Europe|United Kingdom
Validation Method: metagenomic sequencing and comparison with culture results

6

Genetic Characterization of Antibiotic Resistant Enterobacteriaceae Isolates From Bovine Animals and the Environment in Nigeria.

PMID 35283848 · 2022

The study characterizes antibiotic resistance genes in Enterobacteriaceae isolates from bovine animals and the environment in Nigeria, identifying several beta-lactamase, aminoglycoside modifying enzymes, qnr, sulfonamide, tetracycline, and trimethoprim resistance genes, highlighting the presence of multidrug-resistant strains.

Gene Information

Gene Name: blaCKO
Allele: blaCKO–1
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: CeftazidimeCefotaxime
Organisms Tested In: • Enterobacter quasiroggenkampii
• Enterobacter hormachei
• Citrobacter koseri
• Klebsiella quasipneumoniae
• Klebsiella variicola
• Proteus terrae
• Proteus faecis
Geographic Location: Edo state, Nigeria
Validation Method: whole genome sequencing
Sequence Accession: JAIKTX000000000|JAIKUW000000000|JAIKTX010000000|JAIKUW010000000

7

Genetic Characterization of Antibiotic Resistant Enterobacteriaceae Isolates From Bovine Animals and the Environment in Nigeria.

PMID 35283848 · 2022

The study characterizes antibiotic resistance genes in Enterobacteriaceae isolates from bovine animals and the environment in Nigeria, identifying several beta-lactamase, aminoglycoside modifying enzymes, qnr, sulfonamide, tetracycline, and trimethoprim resistance genes, highlighting the presence of multidrug-resistant strains.

Gene Information

Gene Name: blaCKO
Allele: blaMAL–1
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: CeftazidimeCefotaxime
Organisms Tested In: • Enterobacter quasiroggenkampii
• Enterobacter hormachei
• Citrobacter koseri
• Klebsiella quasipneumoniae
• Klebsiella variicola
• Proteus terrae
• Proteus faecis
Geographic Location: Edo state, Nigeria
Validation Method: whole genome sequencing
Sequence Accession: JAIKTX000000000|JAIKUW000000000|JAIKTX010000000|JAIKUW010000000

8

Characterization of the chromosomal class A beta-lactamase CKO from Citrobacter koseri.

PMID unpublished, 16445758 · 2006

Gene Information

Gene Name: blaCKO
Allele: blaMAL-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOTHINAMOXICILLINTICARCILLIN+CLAVULANIC ACIDAMPICILLIN+CLAVULANIC ACIDAMPICILLINAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Citrobacter koseri
Sequence Accession: AJ277209, AJ609506
Notes: Chromosomal class A beta-lactamase

9

Gene Information

Gene Name: blaCKO
Allele: blaMAL-2
Encodes: MAL beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Citrobacter koseri
Sequence Accession: NG_049291.1
Protein Accession: WP_063860834.1
Notes: ARO:3006950

10

Gene Information

Gene Name: blaCKO
Allele: blaMAL-1
Encodes: MAL/CKO family class A beta-lactamase MAL-1
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOTHINAMOXICILLINTICARCILLIN+CLAVULANIC ACIDAMPICILLIN+CLAVULANIC ACIDAMPICILLINBETA-LACTAMAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Citrobacter koseri
Sequence Accession: AJ277209.1
Protein Accession: CAC33434.1
Notes: Chromosomal class A beta-lactamase

11

Gene Information

Gene Name: blaCKO
Allele: blaMAL-1
Encodes: MAL/CKO family class A beta-lactamase MAL-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TICARCILLINCEPHALOTHINAMOXICILLINTICARCILLIN+CLAVULANIC ACIDAMPICILLIN+CLAVULANIC ACIDAMPICILLINBETA-LACTAMAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN
Organisms Tested In: • Citrobacter koseri
Sequence Accession: AJ277209.1
Protein Accession: CAC33434.1
Notes: Chromosomal class A beta-lactamase

12

Gene Information

Gene Name: blaCKO
Allele: blaMAL-2
Encodes: MAL/CKO family class A beta-lactamase MAL-2
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: BETA-LACTAM
Organisms Tested In: • Citrobacter koseri
Sequence Accession: AF359512.1
Protein Accession: AAP80386.1
Notes: ARO:3006950

13

Gene Information

Gene Name: blaCKO
Allele: blaMAL-2
Encodes: MAL/CKO family class A beta-lactamase MAL-2
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: BETA-LACTAM
Organisms Tested In: • Citrobacter koseri
Sequence Accession: AF359512.1
Protein Accession: AAP80386.1
Notes: ARO:3006950

14

Gene Information

Gene Name: blaCKO
Allele: blaMAL-1
Encodes: MAL beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Citrobacter koseri
Sequence Accession: NG_049290.1
Protein Accession: WP_063860833.1
Notes: ARO:3006949