Browse AMR Genes

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blaCSP

extended-spectrum class A beta-lactamase CSP-1

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaCSP

Browse AMR rules for blaCSP

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: whole-genome sequencing
Drug Classes: CEPHALOSPORIN, MEROPENEM, ERTAPENEM, AMOXICILLIN, CEFOXITIN, IMIPENEM, CEFIXIME, CEFEPIME, AMPICILLIN+CLAVULANIC ACID, AMPICILLIN, CEFOTAXIME, CEFTAZIDIME, AMOXICILLIN+CLAVULANIC ACID, PIPERACILLIN+TAZOBACTAM, PIPERACILLIN, Amoxicillin, Ticarcillin, Cephalosporins, Ceftazidime, Cefotaxime, Aztreonam, BETA-LACTAM
Organisms: Capnocytophaga sputigena, Elizabethkingia anophelis subsp. endophytica ML-44
Geographic Location: Russia
Alleles: 2
Papers: 3
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
blaCSP-1	Card DatabaseReference Gene CatalogReslit	4	CEPHALOSPORIN, Amoxicillin +5	Capnocytophaga sputigena +1	Russia	2010, 2022

Papers3

1

Characterization of CSP-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of Capnocytophaga sputigena.

PMID 20308380 · 2010

Gene Information

Gene Name: blaCSP
Allele: blaCSP-1
Encodes: extended-spectrum class A beta-lactamase CSP-1
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Capnocytophaga sputigena
Sequence Accession: GQ217533.1
Protein Accession: ADD82978.1
Notes: ARO:3006871

2

Characterization of CSP-1, a novel extended-spectrum beta-lactamase produced by a clinical isolate of Capnocytophaga sputigena.

PMID 20308380 · 2010

Gene Information

Gene Name: blaCSP
Allele: blaCSP-1
Encodes: extended-spectrum class A beta-lactamase CSP-1
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Capnocytophaga sputigena
Sequence Accession: GQ217533.1
Protein Accession: ADD82978.1
Notes: ARO:3006871

3

The Soil Microbiota Harbors a Diversity of Carbapenem-Hydrolyzing β-Lactamases of Potential Clinical Relevance.

PMID 26482314 · 2016

Gene Information

Gene Name: blaCSP
Allele: blaSPU-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Capnocytophaga sputigena
Sequence Accession: GQ919044
Notes: Chromosomal metallo-beta-lactamase

4

Antimicrobial Resistance and Comparative Genomic Analysis of Elizabethkingia anophelis subsp. endophytica Isolated from Raw Milk.

PMID 35625292 · 2022

The study reports the first isolation of Elizabethkingia anophelis subsp. endophytica from raw milk in Russia, highlighting its multidrug resistance and the presence of various AMR genes including beta-lactamases and efflux pumps.

Gene Information

Gene Name: blaCSP
Allele: blaCSP-1
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: AmoxicillinTicarcillinCephalosporinsCeftazidimeCefotaximeAztreonam
Organisms Tested In: • Elizabethkingia anophelis subsp. endophytica ML-44
Geographic Location: Russia
Validation Method: whole-genome sequencing
Sequence Accession: JAJNCD000000000

5

Gene Information

Gene Name: blaCSP
Allele: blaCSP-1
Encodes: CSP beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Capnocytophaga sputigena
Sequence Accession: NG_048896.1
Protein Accession: WP_063859920.1
Notes: ARO:3006871

6

Gene Information

Gene Name: blaCSP
Allele: blaSPU-1
Encodes: SPU beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Capnocytophaga sputigena
Sequence Accession: NG_050141.1
Protein Accession: WP_063864748.1
Notes: ARO:3006998

7

Gene Information

Gene Name: blaCSP
Allele: blaSPU-1
Encodes: CSP family extended-spectrum class A beta-lactamase SPU-1
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEBETA-LACTAMAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Capnocytophaga sputigena
Sequence Accession: GQ919044.1
Protein Accession: ADK47391.1
Notes: Chromosomal metallo-beta-lactamase

8

Gene Information

Gene Name: blaCSP
Allele: blaSPU-1
Encodes: CSP family extended-spectrum class A beta-lactamase SPU-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEBETA-LACTAMAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Capnocytophaga sputigena
Sequence Accession: GQ919044.1
Protein Accession: ADK47391.1
Notes: Chromosomal metallo-beta-lactamase

9

Gene Information

Gene Name: blaCSP
Allele: blaSPU-1
Encodes: CSP family extended-spectrum class A beta-lactamase SPU-1
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEBETA-LACTAMAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Capnocytophaga sputigena
Sequence Accession: GQ919044.1
Protein Accession: ADK47391.1
Notes: Chromosomal metallo-beta-lactamase