blaDES

beta-lactamase

Validation StatusCandidate

Overview

Mechanism: hydrolysis
Validation Method: cloning in E. coli + MIC testing
Drug Classes: ampicillin, amoxicillin, ticarcillin, cefotaxime, ceftriaxone
Organisms: Desulfovibrio desulfuricans, Escherichia coli
Papers: 1
Databases: Reslit

Papers1

Biochemical-Genetic Analysis and Distribution of DES-1, an Ambler Class A Extended-Spectrum beta-lactamase from Desulfovibrio desulfuricans.

PMID 12234847 · 2002

The study identifies DES-1, a novel Ambler class A extended-spectrum beta-lactamase from Desulfovibrio desulfuricans, which confers resistance to various β-lactam antibiotics including ampicillin, amoxicillin, ticarcillin, cefotaxime, ceftriaxone, and cefoperazone.

Gene Information

Gene Name: blaDES
Allele: blaDES-1
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis
Confers Resistance To: ampicillinamoxicillinticarcillincefotaximeceftriaxone
Organisms Tested In: • Desulfovibrio desulfuricans
• Escherichia coli
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: AF426161

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blaDES

Gene Information