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blaDHT2

metallo-beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaDHT2

Browse AMR rules for blaDHT2

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: expression in E. coli and measurement of MICs
Drug Classes: Imipenem, Ampicillin, Cefoxitin, Cefazolin, Cephalothin, Cefotaxime, Ceftazidime, Ceftriaxone, Cefepime, CARBAPENEM
Organisms: Escherichia coli, uncultured bacterium
Geographic Location: Denmark|Germany|Algeria|Spain|Norway
Alleles: 3
Papers: 1
Databases: Card DatabaseReference Gene CatalogReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
DHT2-1	Reslit	1	Imipenem, Ampicillin +7	Escherichia coli	Denmark\|Germany\|Algeria\|Spain\|Norway	2016	KU167035\|KU167036\|KU167037\|KU167038\|KU167039\|KU167040\|KU167041\|KU167042\|KU167043	-
blaDHT2

Papers1

1

Expanding the Repertoire of Carbapenem-Hydrolyzing Metallo-ß-Lactamases by Functional Metagenomic Analysis of Soil Microbiota.

PMID 28082950 · 2016

Nine carbapenem-hydrolyzing metallo-beta-lactamases (MBLs) were identified in soil microbiota using functional metagenomics. These MBLs included two subclass B1 (GRD23-1 and SPN79-1) and seven subclass B3 (CRD3-1, PEDO-1, GRD33-1, ESP-2, ALG6-1, ALG11-1, and DHT2-1). All MBLs conferred resistance to various β-lactam antibiotics in E. coli.

Gene Information

Gene Name: blaDHT2
Allele: DHT2-1
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: ImipenemAmpicillinCefoxitinCefazolinCephalothinCefotaximeCeftazidimeCeftriaxoneCefepime
Organisms Tested In: • Escherichia coli
Geographic Location: Denmark|Germany|Algeria|Spain|Norway
Validation Method: expression in E. coli and measurement of MICs
Sequence Accession: KU167035|KU167036|KU167037|KU167038|KU167039|KU167040|KU167041|KU167042|KU167043

2

Expanding the Repertoire of Carbapenem-Hydrolyzing Metallo-ß-Lactamases by Functional Metagenomic Analysis of Soil Microbiota.

PMID 28082950 · 2016

Gene Information

Gene Name: blaDHT2
Allele: blaDHT2
Encodes: subclass B3 metallo-beta-lactamase DHT2-1
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • uncultured bacterium
Sequence Accession: KU167035.1
Protein Accession: APR64485.1
Notes: ARO:3006872

3

Expanding the Repertoire of Carbapenem-Hydrolyzing Metallo-ß-Lactamases by Functional Metagenomic Analysis of Soil Microbiota.

PMID 28082950 · 2016

Gene Information

Gene Name: blaDHT2
Allele: blaDHT2
Encodes: subclass B3 metallo-beta-lactamase DHT2-1
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • uncultured bacterium
Sequence Accession: KU167035.1
Protein Accession: APR64485.1
Notes: ARO:3006872

4

Gene Information

Gene Name: blaDHT2
Allele: blaDHT2-1
Encodes: DHT2 beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • uncultured bacterium
Sequence Accession: NG_062233.1
Protein Accession: WP_122630829.1
Notes: ARO:3006872