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subclass B1 metallo-beta-lactamase DIM-1
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaDIM-1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 18 | MEROPENEM, ERTAPENEM +17 |
| Netherlands, Sierra Leone, Ghana, India, Asia/South Pacific|Europe|Latin America|Middle East/Africa|North America, Tanzania, Poland, Europe|Ukraine|Myanmar|Netherlands|United States|India|Uganda|Poland|Pakistan|Tanzania, Bolivia, Europe|Spain |
| 2010, 2013, 2021, 2022, 2023, 2024, 2025 |
| GU323019.1 |
| ADD91577.1 |
| blaDIM | Reslit | 3 | Imipenem, Meropenem | Acinetobacter baumannii +8 | China, India, Europe|Greece | 2019, 2022, 2024 | PRJNA744890 | - |
Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands.
Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands.
The study characterizes DIM-1, a novel metallo-beta-lactamase from a Pseudomonas stutzeri isolate, which confers resistance to carbapenems and broad-spectrum cephalosporins.
Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands.
Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands.
Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands.
Identification of blaOXA-51-like, blaOXA-58, blaDIM-1, and blaVIM carbapenemase genes in hospital Enterobacteriaceae isolates from Sierra Leone.
The study identifies blaOXA-51-like, blaOXA-58-like, blaDIM-1, and blaVIM carbapenemase genes in hospital Enterobacteriaceae isolates from Sierra Leone, highlighting the presence of these resistance genes in non-Acinetobacter species and emphasizing the need for molecular surveillance of carbapenemase gene circulation.
Laboratory and Clinical Evaluation of DNA Microarray for the Detection of Carbapenemase Genes in Gram-Negative Bacteria from Hospitalized Patients.
The study developed a DNA microarray for the detection of eight carbapenemase genes (blaKPC, blaNDM-1, blaOXA-23, blaOXA-48, blaOXA-51, blaIMP, blaVIM, and blaDIM) in Gram-negative bacteria, demonstrating high specificity and sensitivity.
Carbapenem Resistance Determinants Acquired through Novel Chromosomal Integrations in Extensively Drug-Resistant Pseudomonas aeruginosa.
The study identifies two novel carbapenemase-encoding genomic islands, PAGI-97A and PAGI-97B, harboring bla DIM-1 and bla IMP-1, which contribute to carbapenem resistance in extensively drug-resistant Pseudomonas aeruginosa strains.
Dissemination Routes of Carbapenem and Pan-Aminoglycoside Resistance Mechanisms in Hospital and Urban Wastewater Canalizations of Ghana.
The study identified novel and uncommon carbapenemase/β-lactamase gene variants, including bla VIM-71, bla CARB-53, and bla DIM-1, which were associated with multidrug-resistant bacteria in wastewater samples from Ghana. The genes bla NDM-1, armA, and rmtC were also found to confer resistance to carbapenems and aminoglycosides.
Genome-wide identification of carbapenem-resistant Gram-negative bacterial (CR-GNB) isolates retrieved from hospitalized patients in Bihar, India.
The study identified several carbapenem-resistant genes, including bla CTX-M, bla SHV, bla TEM, bla OXA, bla NDM, and bla DIM, in Gram-negative bacterial isolates from Bihar, India. These genes were found to confer resistance to various antibiotics, highlighting the prevalence of carbapenem resistance in the region.
Relative inhibitory activities of the broad-spectrum beta-lactamase inhibitor taniborbactam against metallo-beta-lactamases.
The study evaluates the inhibitory activity of taniborbactam against various metallo-beta-lactamases (MBLs), demonstrating that it effectively inhibits most NDM- and VIM-like enzymes but not SIM-1. Specific mutations in VIM-1 and NDM-1 were found to confer resistance to taniborbactam.
Evaluation of antimicrobial susceptibility tests for Acinetobacter and Pseudomonas species using disks containing a high dose of meropenem.
The study identified several beta-lactamase genes, including blaIMP-1, blaDIM-1, blaNDM-1, blaVIM-1, blaGES-5, blaOXA-23, blaOXA-51-like, and blaADC, which confer resistance to meropenem in Acinetobacter and Pseudomonas species.
An in-depth study on survival mechanism of bacterial isolates in disinfectants within the hospital environment.
The study identified multiple AMR genes, including blaDIM-1, qacE, and various efflux pump genes, in bacterial isolates from hospital disinfectants, indicating their adaptation to survive in disinfectant environments.
Cefepime-taniborbactam activity against antimicrobial-resistant clinical isolates of Enterobacterales and Pseudomonas aeruginosa: GEARS global surveillance programme 2018-22.
Cefepime-taniborbactam showed potent in vitro activity against Enterobacterales and P. aeruginosa, particularly effective against isolates with carbapenemase genes such as blaIMP, blaNDM, and blaVIM, as well as those with mutations in ftsI, ompK35, and ompK36.
Prevalence, Characterization, and Epidemiological Relationships between ESBL and Carbapenemase-Producing Escherichia coli, Klebsiella pneumoniae, and Acinetobacter spp. Isolated from Humans and the Kitchen Environment of Two Greek Hospitals.
The study identified various beta-lactamase genes, including bla SHV, bla CTX-M, bla TEM, bla KPC, bla NDM, bla OXA-48, bla OXA-23, and bla OXA-51, in ESBL and carbapenemase-producing E. coli, K. pneumoniae, and Acinetobacter spp. isolates from hospital kitchens and staff.
Distribution of Carbapenemase Genes Associated With Global High-Risk Sequence Types in Pseudomonas aeruginosa Isolates From Chronic Leg Ulcer Patients in Northern Tanzania.
The study identified various carbapenemase genes, including blaOXA-50, blaOXA-488, blaOXA-396, blaOXA-10, blaOXA-395, blaOXA-486, blaVIM-2, and blaDIM-1, in Pseudomonas aeruginosa isolates from chronic leg ulcer patients in northern Tanzania, highlighting the presence of multidrug-resistant strains.
Antibiotic resistance in white stork cloaca and environmental samples
The study identified various antibiotic resistance genes in bacterial isolates from white stork cloaca and environmental samples, highlighting the presence of resistance mechanisms against beta-lactams, aminoglycosides, quinolones, and polymyxins.
Recurring acquisition of carbapenemase genes and global emergence of Pseudomonas aeruginosa ST-1047, a lineage shaped by geopolitical conflicts.
The study identifies the recurrence of carbapenemase genes, including blaIMP-1, blaVIM-11, blaNDM-1, and blaDIM-1, in Pseudomonas aeruginosa ST-1047, highlighting their role in the global spread of this lineage, particularly linked to geopolitical conflicts.
First nationwide survey on Pseudomonas aeruginosa in Bolivia: susceptibility profiles, resistome, and genomic epidemiology.
The study identified multiple carbapenemases, extended-spectrum beta-lactamases, and 16S rRNA methyltransferases in multidrug-resistant Pseudomonas aeruginosa isolates from Bolivia, highlighting the prevalence of high-risk clones and resistance mechanisms.
First report of a DIM-1-producing Pseudomonas aeruginosa in Spain: genomic characterization and resistance determinants.
The study reports the first DIM-1-producing Pseudomonas aeruginosa isolate in Spain, highlighting the presence of the blaDIM-1 gene within a class 1 integron, along with other resistance genes, contributing to multidrug resistance.
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