Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
metallo-beta-lactamase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaFIM-1 | Card DatabaseReference Gene CatalogReslit | 6 | Carbapenem, Penicillin +3 | Pseudomonas aeruginosa +1 | Italy, Southern Italy, Europe|Italy | 2013, 2024, 2025 | JX570731 |
| AFV91534.1 |
| bla_FIM-1 | Reslit | 1 | Carbapenem, Cephalosporin +1 | Pseudomonas aeruginosa | Italy | 2024 | CP150882|CP150883 | - |
| blaFIM | Reslit | 1 | Ceftazidime, Ceftazidime-avibactam +1 | Klebsiella pneumoniae | Europe | 2025 | - | - |
FIM-1, a new acquired metallo-beta-lactamase from a Pseudomonas aeruginosa clinical isolate from Italy.
The study identifies and characterizes FIM-1, a new acquired metallo-beta-lactamase from a multidrug-resistant Pseudomonas aeruginosa isolate, which confers resistance to various β-lactam antibiotics including carbapenems, penicillins, and cephalosporins.
FIM-1, a new acquired metallo-β-lactamase from a Pseudomonas aeruginosa clinical isolate from Italy.
FIM-1, a new acquired metallo-β-lactamase from a Pseudomonas aeruginosa clinical isolate from Italy.
Novel resistance ICEs carrying the blaFIM-1 metallo-beta-lactamase gene from an ST235 Pseudomonas aeruginosa sublineage.
The study identifies the blaFIM-1 gene, a metallo-beta-lactamase, in two closely related Pseudomonas aeruginosa strains, FI-14/157 and FI-17645, which show resistance to multiple antibiotics except colistin, cefiderocol, and aztreonam.
Pseudomonas aeruginosa producing FIM-1-metallo-β-lactamase: emergence and cross-transmission in a long-term acute care rehabilitation hospital.
The study reports on FIM-1-positive P. aeruginosa strains from two patients who shared the same ward in a long-term acute care rehabilitation hospital, highlighting the emergence and potential cross-transmission of these strains.
Resistance to ceftazidime-avibactam and other new β-lactams in Pseudomonas aeruginosa clinical isolates: a multi-center surveillance study.
The study identified metallo-beta-lactamases (VIM-2, VIM-1, FIM-1), extended-spectrum beta-lactamases (PER-1, GES-1), and other beta-lactamase genes as the primary mechanisms of resistance to ceftazidime-avibactam in Pseudomonas aeruginosa clinical isolates.
Next-generation diagnostics of bloodstream infections enabled by rapid whole-genome sequencing of bacterial cells purified from blood cultures.
The study presents a rapid whole-genome sequencing workflow (LC-WGS) for diagnosing bloodstream infections, demonstrating accurate identification of bacterial pathogens and detection of clinically relevant resistance markers within 4.2 hours. The workflow successfully identified various AMR genes, including bla CTX-M-15, bla DHA-1, bla KPC-2, bla KPC-3, bla NDM-1, bla OXA-23, armA, mecA, vanRSHAXYZ, aac(6')-Ie/aph(2'')-Ia, aph(3')-IIIa, aac(6')-I, sul1, and dfrA17.
Evaluation of QuickMIC system for rapid antimicrobial susceptibility testing of Gram-negative pathogens from positive blood cultures, including strains producing extended-spectrum β-lactamases and carbapenemases.
The study evaluated the QuickMIC system for rapid antimicrobial susceptibility testing of Gram-negative pathogens, including strains producing extended-spectrum β-lactamases (ESBLs) and carbapenemases. It identified several β-lactamase genes such as bla CTX-M, bla KPC, bla NDM, bla VIM, bla OXA-23-like, bla FIM, and bla VEB, which confer resistance to various beta-lactam antibiotics.
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