Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
non-heme iron-binding ferritin
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| fri | Reslit | 1 | Penicillin, Ampicillin +2 | Listeria monocytogenes | - | 2012 | - | - |
| blaFRI-1 | Card DatabaseReference Gene Catalog |
| 9 |
| AZTREONAM, MEROPENEM +22 |
| Enterobacter cloacae +3 |
| France|Switzerland, USA|Global, Europe, Switzerland |
| 2015, 2022, 2023 |
| KT192551.1 |
| ALE30770.1 |
| blaFRI-2 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, MEROPENEM +8 | Enterobacter asburiae | - | 2017, 2018 | KX620467 | ANZ90381.1 |
| blaFRI-4 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, MEROPENEM +14 | Enterobacter asburiae | - | 2018 | LC178555.1 | BAX00166.1 |
| blaFLC-1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | Carbapenem, AMOXICILLIN +4 | Enterobacter cloacae complex +4 | India | 2019 | CP033466|CP033467|CP033468|CP033469|ATX60370.1 | ATX60370.1 |
| blaFRI-6 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, MEROPENEM +14 | Enterobacter cloacae | - | 2020 | MK248729.1 | AZK35806.1 |
| blaFRI-11 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | AZTREONAM, MEROPENEM +15 | Enterobacter sp. JBIWA008 +2 | China | 2022, 2023, 2025 | CP074152.1 | UAN43462.1 |
| blaFRI-8 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | Meropenem, Ertapenem +17 | Enterobacter asburiae +2 | Canada | 2023 | PRJNA804546|JAKRWQ000000000 | BBJ69931.1 |
| blaFRI-12 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | Imipenem, Ertapenem +19 | Enterobacter asburiae +1 | Canada, China|Europe|Americas|Asia|North Africa|Middle East | 2024, 2025 | NG_081789.1|PRJNA865257 | UUM03679.1 |
| blaFRI-5 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, MEROPENEM +14 | Enterobacter cloacae complex sp. | - | - | MH208723 | AWA42532.1 |
| blaFRI-3 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, MEROPENEM +14 | Enterobacter cloacae | - | - | KY524440 | AQS23610.1 |
| blaFRI-7 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, MEROPENEM +14 | Enterobacter asburiae | - | - | AP019534 | BBI97867.1 |
| blaFRI-10 | Card DatabaseReference Gene CatalogResFinder Database | 5 | AZTREONAM, MEROPENEM +14 | Escherichia coli | - | - | MW349709 | WP_204376226.1 |
| blaFRI-9 | Card DatabaseReference Gene CatalogResFinder Database | 4 | AZTREONAM, MEROPENEM +14 | Enterobacter asburiae | - | - | AP038771 | BBJ65425.1 |
Identification of a ferritin-like protein of Listeria monocytogenes as a mediator of β-lactam tolerance and innate resistance to cephalosporins.
The study identifies the ferritin-like protein Fri as a mediator of β-lactam tolerance and innate resistance to cephalosporins in Listeria monocytogenes. Disruption of the fri gene increases sensitivity to penicillin G, ampicillin, cefalotin, and cephradine.
Genetic and Biochemical Characterization of FRI-1, a Carbapenem-Hydrolyzing Class A β-Lactamase from Enterobacter cloacae.
Genetic and Biochemical Characterization of FRI-1, a Carbapenem-Hydrolyzing Class A β-Lactamase from Enterobacter cloacae.
Genetic and Biochemical Characterization of FRI-1, a Carbapenem-Hydrolyzing Class A β-Lactamase from Enterobacter cloacae.
Genetic and Biochemical Characterization of FRI-1, a Carbapenem-Hydrolyzing Class A beta-lactamase from Enterobacter cloacae.
The study identifies FRI-1, a novel plasmid-encoded class A carbapenemase from Enterobacter cloacae, which hydrolyzes carbapenems, penicillins, and aztreonam.
Genetic and Biochemical Characterization of FRI-1, a Carbapenem-Hydrolyzing Class A β-Lactamase from Enterobacter cloacae.
Class A Carbapenemases: Mechanisms of Action and Resistance
The paper characterizes various class A carbapenemases, including KPC, GES, SME, NmcA, FRI-1, BIC-1, SFC-1, and PenA, highlighting their roles in conferring resistance to carbapenems and other β-lactam antibiotics.
FRI-2 carbapenemase-producing Enterobacter cloacae complex in the UK.
FRI-4 carbapenemase-producing Enterobacter cloacae complex isolated in Tokyo, Japan.
FRI-4 carbapenemase-producing Enterobacter cloacae complex isolated in Tokyo, Japan.
FRI-4 carbapenemase-producing Enterobacter cloacae complex isolated in Tokyo, Japan.
FRI-4 carbapenemase-producing Enterobacter cloacae complex isolated in Tokyo, Japan.
FRI-4 carbapenemase-producing Enterobacter cloacae complex isolated in Tokyo, Japan.
FRI-4 carbapenemase-producing Enterobacter cloacae complex isolated in Tokyo, Japan.
FRI-4 carbapenemase-producing Enterobacter cloacae complex isolated in Tokyo, Japan.
Novel Carbapenemases FLC-1 and IMI-2 Encoded by an Enterobacter cloacae Complex Isolated from Food Products.
The study identifies two novel carbapenemases, FLC-1 and IMI-2, encoded by an Enterobacter cloacae complex isolate from imported seafood. Both enzymes belong to Ambler class A beta-lactamases and confer resistance to carbapenems.
Novel Carbapenemases FLC-1 and IMI-2 Encoded by an Enterobacter cloacae Complex Isolated from Food Products.
Enterobacter sp. N18-03635 harbouring blaFRI-6 class A carbapenemase, Canada.
Enterobacter sp. N18-03635 harbouring blaFRI-6 class A carbapenemase, Canada.
Enterobacter sp. N18-03635 harbouring blaFRI-6 class A carbapenemase, Canada.
Enterobacter sp. N18-03635 harbouring blaFRI-6 class A carbapenemase, Canada.
Breaking antimicrobial resistance by disrupting extracytoplasmic protein folding.
Disruption of DsbA-mediated disulfide bond formation incapacitates diverse β-lactamases and destabilizes mobile colistin resistance enzymes. Chemical inhibition of DsbA sensitizes multidrug-resistant clinical isolates to existing antibiotics.
Emergence of rare carbapenemases (FRI, GES-5, IMI, SFC and SFH-1) in Enterobacterales isolated from surface waters in Japan.
Emergence of rare carbapenemases (FRI, GES-5, IMI, SFC and SFH-1) in Enterobacterales isolated from surface waters in Japan.
Emergence of rare carbapenemases (FRI, GES-5, IMI, SFC and SFH-1) in Enterobacterales isolated from surface waters in Japan.
A rare class A carbapenemase FRI-11 in Enterobacter clinical strain.
Genetic and Phenotypic Characterization of the First Canadian Case of Ambler Class A Carbapenemase FRI-8.
The study identifies the first clinical isolate in Canada carrying the blaFRI-8 gene, which confers resistance to carbapenems. The gene was found on a 148 kb IncFII(Yp) plasmid in Enterobacter asburiae.
Genetic and Phenotypic Characterization of the First Canadian Case of Ambler Class A Carbapenemase FRI-8.
Impact of Minor Carbapenemases on Susceptibility to Novel β-Lactam/β-Lactamase Inhibitor Combinations and Cefiderocol in Enterobacterales.
The study characterizes the impact of minor carbapenemases (SME-1, NmcA, IMI-1, and FRI-1) on susceptibility to imipenem-relebactam, meropenem-vaborbactam, and cefiderocol in Enterobacterales. It shows that these carbapenemases significantly reduce susceptibility to imipenem-relebactam but not to meropenem-vaborbactam or cefiderocol.
Impact of acquired broad-spectrum beta-lactamases on susceptibility to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) alone or in combination with avibactam and taniborbactam beta-lactamase inhibitors in Escherichia coli.
The study evaluates the impact of various beta-lactamases on the susceptibility of Escherichia coli to oral penems/carbapenems (tebipenem, sulopenem, and faropenem) and their combinations with beta-lactamase inhibitors avibactam and taniborbactam.
Emergence of a novel FRI-type carbapenemase; blaFRI-12 in Enterobacter asburiae located on an IncR plasmid.
The study identifies a novel FRI-type carbapenemase, blaFRI-12, in Enterobacter asburiae, which confers resistance to carbapenems and aztreonam. The gene was found on a 104 Kb IncR plasmid and was functionally validated through cloning and susceptibility testing.
Emergence of a novel FRI-type carbapenemase; blaFRI-12 in Enterobacter asburiae located on an IncR plasmid.
Epidemiological and biological characteristics of IncR plasmids as multihost antibiotic resistance carriers.
The study characterizes various AMR genes carried by IncR plasmids, highlighting their role in the dissemination of resistance to carbapenems, cephalosporins, fluoroquinolones, aminoglycosides, and tetracyclines.
The clinical impact and dissemination of carbapenemase-producing Enterobacter: a genome-based study in China.
The study identifies blaNDM-1, blaNDM-5, blaIMP-4, blaFRI-11, and blaKPC-2 as the primary carbapenemase genes in carbapenemase-producing Enterobacter (CPEn) isolates in China, predominantly found in E. xiangfangensis and E. hoffmannii. These genes confer resistance to carbapenems and are widespread across various Enterobacter species.
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