The study presents a microarray-based assay for the rapid identification of carbapenemase genes in Gram-negative bacteria, including bla KPC, bla VIM, bla NDM, bla GIM, bla OXA-23, bla OXA-48-group, bla OXA-51, bla OXA-58, and various beta-lactamase genes such as bla OXA-1, bla OXA-2, bla OXA-7, bla OXA-9, bla OXA-10, bla CTX-M1, and bla CTX-M15.

The study identifies a novel metallo-beta-lactamase variant, GIM-2, in a clinical isolate of Enterobacter cloacae, which confers resistance to carbapenems.

The study reviews the dissemination of carbapenemase-producing Gram-negative bacteria in the Middle East, highlighting the prevalence of KPC, VIM, IMP, NDM, and OXA-48 enzymes in various bacterial species such as Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa.

The study identifies the blaGIM-1 gene as a significant contributor to carbapenem resistance in various environmental bacteria, highlighting its role in a long-term outbreak. The gene was found in 12 different species, demonstrating its widespread presence and potential for horizontal gene transfer.

The study identifies multiple AMR genes and mutations in Pseudomonas aeruginosa, including aadA1, aadA6, aacA4, aacA7, aacA5, blaOXA-2, blaOXA-4, blaVIM-1, blaVIM-2, blaGIM-2, blaIMP-1, blaIMP-7, blaPER-1, blaCTX-M-3, ampC, gyrA (T83I), and parC (S87L/W), which are associated with resistance to various antibiotics such as tobramycin, ceftazidime, meropenem, and ciprofloxacin.

The study identifies the metallo-beta-lactamase GIM-1 as a significant resistance factor in Serratia marcescens, highlighting its regional dissemination and genetic stability over decades.

The study presents a new method for the rapid detection of carbapenemases directly from positive blood cultures using the β-CARBA test, achieving 100% sensitivity and 94.3% specificity for various carbapenemase types including OXA-48-like, NDM, KPC, VIM, and GIM.

The study detected carbapenemase-producing Pseudomonas aeruginosa isolates, with bla VIM, bla NDM-1, bla SIM, and bla GIM being the most prevalent genes. Co-production of multiple carbapenemase genes was also observed.

The study identified multiple AMR genes including IMP, VIM, OPR, SIM, SPM, GIM, NDM, VEB, PER, KPC, OXA, intI, intII, intIII, SHV, TEM, and CTXM in extensively drug-resistant Pseudomonas aeruginosa isolates. These genes conferred resistance to various antibiotics, particularly carbapenems and beta-lactams.

The study identified the bla GIM gene in the CR-HMKP isolate NY03, which confers resistance to ceftazidime/avibactam. Phage kpssk3 showed high efficacy in treating CR-HMKP bacteremia in a mouse model with no significant toxicity.

The study identified blaNDM, blaVIM, blaSPM, blaIMP, and blaGIM carbapenem resistance genes in carbapenem-resistant Gram-negative bacilli from patients with ventilator-associated pneumonia, with blaNDM being the most prevalent.

The study identified multiple antimicrobial resistance (AMR) genes and mutations in the Serratia marcescens complex, highlighting the presence of hospital-adapted lineages with a high prevalence of multidrug-resistant (MDR) strains. Key AMR genes include blaCTX-M, blaNDM, blaOXA, qnrS1, tet(A), aac(6')-Ib, mph(A), erm(B), aadA, floR, sul1, and dfrA12, which confer resistance to various antibiotics such as beta-lactams, fluoroquinolones, tetracyclines, aminoglycosides, macrolides, florfenicol, sulfonamides, and trimethoprim.

The study reports the emergence of GIM-1 and SIM-1 producing Enterobacteriaceae clinical isolates in Sudan, highlighting their resistance to carbapenems and other antibiotics.

The study identified various antimicrobial resistance genes (ARGs) in humans and food-producing animals in Brazil, including novel carbapenemase-encoding genes such as blaAIM-1, blaCAM-1, blaGIM-2, and blaHMB-1, which were not previously reported in Latin America. Other significant ARGs included aac(6')-Ib-cr, ermF, ermB, ermG, tetO, tetQ, tetW, qnrB10, qnrB19, qnrD1, and crpP.

The study evaluated the performance of phenotypic tests (MHT, mCIM, BCT, CDT) versus genotypic tests for detecting carbapenemase-producing Gram-negative bacilli (CPO). It identified bla KPC, bla NDM, bla VIM, bla GIM, and bla OXA−48 as the most prevalent carbapenemase genes among the isolates.

The paper reviews the molecular characteristics of carbapenem-resistant Acinetobacter baumannii, focusing on carbapenemases. It identifies several beta-lactamase genes, including OXA-23, OXA-51, OXA-58, VIM, NDM, IMP, KPC, and GES, which confer resistance to carbapenems. The study highlights the role of mobile genetic elements in the dissemination of these resistance genes.

Xeruborbactam (XER) showed superior in vitro potency against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales when combined with various β-lactam antibiotics compared to other β-lactam/β-lactamase inhibitor combinations. XER effectively inhibited a wide range of β-lactamases, including metallo-β-lactamases (MBLs) and serine β-lactamases, enhancing the activity of antibiotics such as meropenem, cefepime, ceftolozane, ceftriaxone, aztreonam, piperacillin, and ertapenem.

The study evaluated the gene expressions of Metallo-beta-lactamase genes GIM, VIM, and SPM in Pseudomonas aeruginosa clinical isolates, highlighting their role in carbapenem resistance.

The study evaluates the inhibitory activity of taniborbactam against various metallo-beta-lactamases (MBLs), demonstrating that it effectively inhibits most NDM- and VIM-like enzymes but not SIM-1. Specific mutations in VIM-1 and NDM-1 were found to confer resistance to taniborbactam.

The study developed a novel microarray technique using photoactivated 96-well plates to identify and quantify beta-lactamase genes and their RNA transcripts. The method successfully detected various beta-lactamase genes, including ESBLs, inhibitor-resistant beta-lactamases, and carbapenemases, demonstrating high specificity and reproducibility.

The study identified carbapenemase genes such as bla NDM-1, bla VIM-2, bla GIM-1, and bla OXA-48 like in heteroresistant Gram-negative clinical isolates, highlighting their role in carbapenem resistance.

Cefepime-taniborbactam showed potent in vitro activity against Enterobacterales and P. aeruginosa, particularly effective against isolates with carbapenemase genes such as blaIMP, blaNDM, and blaVIM, as well as those with mutations in ftsI, ompK35, and ompK36.

This study identified 17 distinct antibiotic resistance genes across 53 P-type T4SS-encoding plasmids in Acinetobacter species, including various beta-lactamases, aminoglycoside modifying enzymes, and others, highlighting the significant diversity of resistance determinants carried by these plasmids.

The study introduces dynamically chiral phosphonic acid-based inhibitors that effectively inhibit metallo-β-lactamase enzymes VIM-2, GIM-1, and NDM-1, providing a novel approach to combat β-lactam resistance.

The study identifies bla VIM, bla IMP, and bla NDM as the most commonly detected MBL genes in Acinetobacter clinical isolates globally, with high resistance rates to carbapenems, cephalosporins, and fluoroquinolones.