Browse AMR Genes

Explore antimicrobial resistance genes from the literature

blaHER

class A beta-lactamase HER-8, HER beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaHER

Browse AMR rules for blaHER

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic inactivation, antibiotic inactivation
Validation Method: cloning and MIC testing
Drug Classes: BETA-LACTAM, AMOXICILLIN, AMPICILLIN, TICARCILLIN, Amoxicillin, Ticarcillin, Ampicillin
Organisms: Atlantibacter hermannii, Escherichia hermannii, Escherichia coli, Salmonella enterica subsp. enterica serovar Anatum, Salmonella enterica
Geographic Location: United States
Alleles: 7
Papers: 3
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants7

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
blaHER-8	Card DatabaseReference Gene CatalogResFinder Database	3	BETA-LACTAM, AMOXICILLIN +2	Atlantibacter hermannii	-	2003	AJ536092.1

Papers3

1

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

Gene Information

Gene Name: blaHER
Allele: blaHER-8
Encodes: class A beta-lactamase HER-8, HER beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINTICARCILLIN
Organisms Tested In: • Atlantibacter hermannii
Sequence Accession: AJ536092.1
Protein Accession: CAD60972.1
Notes: Chromosomal class A beta-lactamase, ARO:3008206

2

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

Gene Information

Gene Name: blaHER
Allele: blaHER-8
Encodes: class A beta-lactamase HER-8
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINTICARCILLIN
Organisms Tested In: • Atlantibacter hermannii
Sequence Accession: AJ536092.1
Protein Accession: CAD60972.1
Notes: Chromosomal class A beta-lactamase

3

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

The study identifies a novel class A beta-lactamase, HER-1, from Escherichia hermannii, which confers resistance to amoxicillin and ticarcillin through hydrolysis of beta-lactam antibiotics.

Gene Information

Gene Name: blaHER
Allele: blaHER-1
Encodes: class A beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of beta-lactam antibiotics
Confers Resistance To: AmoxicillinTicarcillin
Organisms Tested In: • Escherichia hermannii
• Escherichia coli
Validation Method: cloning and MIC testing
Sequence Accession: AF311385|AF398334|AF398335|AJ536088|AJ536089|AJ536090|AJ536091|AJ536092

4

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

Gene Information

Gene Name: blaHER
Allele: blaHER-5
Encodes: class A beta-lactamase HER-5
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINTICARCILLIN
Organisms Tested In: • Atlantibacter hermannii
Sequence Accession: AJ536089.1
Protein Accession: CAD60969.1
Notes: Chromosomal class A beta-lactamase

5

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

Gene Information

Gene Name: blaHER
Allele: blaHER-5
Encodes: class A beta-lactamase HER-5, HER beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINTICARCILLIN
Organisms Tested In: • Atlantibacter hermannii
Sequence Accession: AJ536089.1
Protein Accession: CAD60969.1
Notes: Chromosomal class A beta-lactamase, ARO:3008204

6

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

Gene Information

Gene Name: blaHER
Allele: blaHER-6
Encodes: class A beta-lactamase HER-6
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINTICARCILLIN
Organisms Tested In: • Atlantibacter hermannii
Sequence Accession: AJ536090.1
Protein Accession: CAD60970.1
Notes: Chromosomal class A beta-lactamase

7

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

Gene Information

Gene Name: blaHER
Allele: blaHER-6
Encodes: class A beta-lactamase HER-6
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINTICARCILLIN
Organisms Tested In: • Atlantibacter hermannii
Sequence Accession: AJ536090.1
Protein Accession: CAD60970.1
Notes: Chromosomal class A beta-lactamase

8

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

Gene Information

Gene Name: blaHER
Allele: blaHER-6
Encodes: class A beta-lactamase HER-6, HER beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINTICARCILLIN
Organisms Tested In: • Atlantibacter hermannii
Sequence Accession: AJ536090.1
Protein Accession: CAD60970.1
Notes: Chromosomal class A beta-lactamase, ARO:3008205

9

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

Gene Information

Gene Name: blaHER
Allele: blaHER-1
Encodes: penicillin-hydrolyzing class A beta-lactamase HER-1
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINTICARCILLIN
Organisms Tested In: • Atlantibacter hermannii
Sequence Accession: AF311385.1
Protein Accession: AAL26797.1
Notes: Chromosomal class A beta-lactamase

10

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

Gene Information

Gene Name: blaHER
Allele: blaHER-1
Encodes: penicillin-hydrolyzing class A beta-lactamase HER-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINTICARCILLIN
Organisms Tested In: • Atlantibacter hermannii
Sequence Accession: AF311385.1
Protein Accession: AAL26797.1
Notes: Chromosomal class A beta-lactamase

11

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

Gene Information

Gene Name: blaHER
Allele: blaHER-1
Encodes: penicillin-hydrolyzing class A beta-lactamase HER-1, HER beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINTICARCILLIN
Organisms Tested In: • Atlantibacter hermannii
Sequence Accession: AF311385.1
Protein Accession: AAL26797.1
Notes: Chromosomal class A beta-lactamase, ARO:3008200

12

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

Gene Information

Gene Name: blaHER
Allele: blaHER-2
Encodes: class A beta-lactamase HER-2
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINTICARCILLIN
Organisms Tested In: • Atlantibacter hermannii
Sequence Accession: AF398334.1
Protein Accession: AAL26995.1
Notes: Chromosomal class A beta-lactamase

13

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

Gene Information

Gene Name: blaHER
Allele: blaHER-2
Encodes: class A beta-lactamase HER-2
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINTICARCILLIN
Organisms Tested In: • Atlantibacter hermannii
Sequence Accession: AF398334.1
Protein Accession: AAL26995.1
Notes: Chromosomal class A beta-lactamase

14

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

Gene Information

Gene Name: blaHER
Allele: blaHER-2
Encodes: class A beta-lactamase HER-2, HER beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINTICARCILLIN
Organisms Tested In: • Atlantibacter hermannii
Sequence Accession: AF398334.1
Protein Accession: AAL26995.1
Notes: Chromosomal class A beta-lactamase, ARO:3008201

15

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

Gene Information

Gene Name: blaHER
Allele: blaHER-3
Encodes: class A beta-lactamase HER-3
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINTICARCILLIN
Organisms Tested In: • Atlantibacter hermannii
Sequence Accession: AF398335.1
Protein Accession: AAL26996.1
Notes: Chromosomal class A beta-lactamase

16

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

Gene Information

Gene Name: blaHER
Allele: blaHER-3
Encodes: class A beta-lactamase HER-3
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINTICARCILLIN
Organisms Tested In: • Atlantibacter hermannii
Sequence Accession: AF398335.1
Protein Accession: AAL26996.1
Notes: Chromosomal class A beta-lactamase

17

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

Gene Information

Gene Name: blaHER
Allele: blaHER-3
Encodes: class A beta-lactamase HER-3, HER beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINTICARCILLIN
Organisms Tested In: • Atlantibacter hermannii
Sequence Accession: AF398335.1
Protein Accession: AAL26996.1
Notes: Chromosomal class A beta-lactamase, ARO:3008202

18

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

Gene Information

Gene Name: blaHER
Allele: blaHER-4
Encodes: class A beta-lactamase HER-4
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINTICARCILLIN
Organisms Tested In: • Atlantibacter hermannii
Sequence Accession: AJ536088.1
Protein Accession: CAD60968.1
Notes: Chromosomal class A beta-lactamase

19

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

Gene Information

Gene Name: blaHER
Allele: blaHER-4
Encodes: class A beta-lactamase HER-4
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINTICARCILLIN
Organisms Tested In: • Atlantibacter hermannii
Sequence Accession: AJ536088.1
Protein Accession: CAD60968.1
Notes: Chromosomal class A beta-lactamase

20

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

Gene Information

Gene Name: blaHER
Allele: blaHER-4
Encodes: class A beta-lactamase HER-4, HER beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINTICARCILLIN
Organisms Tested In: • Atlantibacter hermannii
Sequence Accession: AJ536088.1
Protein Accession: CAD60968.1
Notes: Chromosomal class A beta-lactamase, ARO:3008203

21

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

Gene Information

Gene Name: blaHER
Allele: blaHER-5
Encodes: class A beta-lactamase HER-5
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINTICARCILLIN
Organisms Tested In: • Atlantibacter hermannii
Sequence Accession: AJ536089.1
Protein Accession: CAD60969.1
Notes: Chromosomal class A beta-lactamase

22

Molecular and biochemical characterization of a novel class A beta-lactamase (HER-1) from Escherichia hermannii.

PMID 12878539 · 2003

Gene Information

Gene Name: blaHER
Allele: blaHER-8
Encodes: class A beta-lactamase HER-8
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: BETA-LACTAMAMOXICILLINAMPICILLINTICARCILLIN
Organisms Tested In: • Atlantibacter hermannii
Sequence Accession: AJ536092.1
Protein Accession: CAD60972.1
Notes: Chromosomal class A beta-lactamase

23

Toward the Adoption of Loop-Mediated Isothermal Amplification for Salmonella Screening at the National Antimicrobial Resistance Monitoring System's Retail Meat Sites.

PMID 36367550 · 2022

The study characterized several AMR genes in Salmonella isolates, including aac(3)-IVa, aph(4)-Ia, floR, sul1, tet(A), and gyrA_D87Y, which conferred resistance to various antibiotics such as chloramphenicol, gentamicin, nalidixic acid, and tetracycline. Additionally, other genes like aac(3)-VIa, aadA1, bla HER-3, aph(3″)-Ib, aph(6)-Id, aac(2′)-IIa, fosA7.4, and tet(B) were identified, each associated with resistance to specific antibiotics.

Gene Information

Gene Name: blaHER
Allele: blaHER-3
Encodes: beta-lactamase
Source Database: Reslit
Organisms Tested In: • Salmonella enterica subsp. enterica serovar Anatum
Geographic Location: United States
Validation Method: whole-genome sequencing
Sequence Accession: PRJNA292661

24

Comparison of genotypic and phenotypic antimicrobial resistance profiles of Salmonella enterica isolates from poultry diagnostic specimens.

PMID 38571400 · 2024

The study identified 31 AMR genes in 97 Salmonella enterica isolates from poultry, including aac(3)-IId, aac(3)-IVa, aac(3)-VIa, aac(6′)-Ib4, ant(2′′)-Ia, grdA, aph(3′)-Ia, aph(3′)-IIa, aadA1, aadA2, aadA7, aadA13, aph(3′)-Ib, aph(6)-Ic, aph(6)-Id, aph(4)-Ia, blaCMY-2, blaCTX-M-1, blaHER-3, blaTEM-1, floR, tetA, tetB, tetC, dfrA12, sul1, sul2, fosA7, qnrB19, ble, and mcr-9.

Gene Information

Gene Name: blaHER
Allele: blaHER-3
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: Ampicillin
Organisms Tested In: • Salmonella enterica
Geographic Location: United States
Validation Method: whole-genome sequencing
Sequence Accession: PRJNA993710