Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
penicillinase repressor BlaI
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| BlaI | Reference Gene CatalogReslit | 16 | BETA-LACTAM, Penicillin +4 | Staphylococcus aureus +2 | Belgium, Germany, Italy, Europe|retail meat products, New Zealand, Europe, Benin, Thuringia, Germany, Vermont | 1991, 2014, 2016, 2017, 2018, 2020, 2021, 2022, 2023, 2024, 2025 | M62650.1 |
| AAA26603.1 |
| blaI | Card Database | 1 | - | Shouchella clausii | - | - | EF540343.1 | ABU39978.1 |
Nucleotide sequence of beta-lactamase regulatory genes from staphylococcal plasmid pI258.
Epidemiology and molecular characterization of methicillin-resistant Staphylococcus aureus nasal carriage isolates from bovines.
The study identified multiple AMR genes in MRSA isolates from bovines, including blaZ, blaI, blaR, tetM, ermC, aacA-aphD, aadD, aphA3, cat, sdrM, and fosB, which confer resistance to penicillin, tetracycline, erythromycin, gentamicin, kanamycin, chloramphenicol, and fosfomycin.
Characterization of Methicillin-Resistant Staphylococcus aureus Isolated from Healthy Turkeys and Broilers Using DNA Microarrays.
The study identified several AMR genes in MRSA isolates from healthy turkeys and broilers, including ermA, ermB, ermC, tetK, tetM, lnuA, mphC, vgaA, aadD, aphA3, blaZ, blaI, blaR, and mecA. These genes conferred resistance to various antibiotics such as erythromycin, clindamycin, tetracycline, lincomycin, macrolides, streptogramins, tobramycin, neomycin, kanamycin, and beta-lactam antibiotics.
Genomic comparison between Staphylococcus aureus GN strains clinically isolated from a familial infection case: IS1272 transposition through a novel inverted repeat-replacing mechanism.
The study identifies the presence of penicillin resistance genes blaZ, blaR1, and blaI in Staphylococcus aureus GN strains, highlighting their role in penicillin resistance.
Death Associated to Methicillin Resistant Staphylococcus aureus ST8 Infection in Two Dolphins Maintained Under Human Care, Italy.
The study reports the isolation of Methicillin-resistant Staphylococcus aureus (MRSA) from two dolphins, identifying the presence of the methicillin-resistance gene mecA, penicillase genes blaZ, blaI, and blaR, as well as genes for macrolide resistance (ermC) and aminoglycoside resistance (aadD).
Comparative Genomics of Plasmid-Bearing Staphylococcus aureus Strains Isolated From Various Retail Meats.
The study identified various antimicrobial resistance (AMR) genes in plasmid-bearing Staphylococcus aureus strains isolated from retail meats, including tetracycline resistance genes (tetM, tetK, tetL, tetT), bacitracin resistance genes (bceA, bceB, bceR, bceS), fluoroquinolone resistance genes (parC, parE, gyrA, gyrB), multidrug efflux pump gene (acrB), fosfomycin resistance gene (fosB), and heavy metal resistance genes (CzcD, CzrB, TR).
The Genetic Relatedness and Antimicrobial Resistance Patterns of Mastitis-Causing Staphylococcus aureus Strains Isolated from New Zealand Dairy Cattle.
The study identified 14 AMR-associated genes, including blaI, blaR1, blaZ, tet(38), merR1, and norB4, in S. aureus isolates from New Zealand dairy cattle. These genes were associated with resistance to penicillin, tetracycline, mercury, and ciprofloxacin. The presence of resistance genes remained low, and no significant associations were found between resistance genes and antimicrobial usage or dry cow therapy.
Survey of Staphylococcus aureus carriage by free-living red deer (Cervus elaphus): Evidence of human and domestic animal lineages.
The study identified several Staphylococcus aureus lineages in free-living red deer, including CC425, CC2671, and CC350, which were prevalent in nasal and intestinal samples. Resistance genes such as blaZ, blaI, blaR, and ermA were detected, along with virulence factors like lukM/lukF-P83, seb, sak, chp, and scn. No methicillin-resistant S. aureus (MRSA) was found.
In Silico Drug Discovery Strategies Identified ADMET Properties of Decoquinate RMB041 and Its Potential Drug Targets against Mycobacterium tuberculosis.
Decoquinate RMB041 was identified as a potential drug candidate against Mycobacterium tuberculosis, with Cyp130 and BlaI as key targets. Computational and in silico analyses suggest that these targets are involved in critical metabolic and regulatory pathways, making them viable candidates for drug development.
Phenotypic and genomic assessment of the potential threat of human spaceflight-relevant Staphylococcus capitis isolates under stress conditions.
All four Staphylococcus capitis strains were found to be resistant to fosfomycin, with no significant differences in antibiotic susceptibility among the strains.
Detecting patterns of accessory genome coevolution in Staphylococcus aureus using data from thousands of genomes.
The study identifies coevolving genes in Staphylococcus aureus, highlighting interactions among antibiotic resistance genes, mobile genetic elements, and virulence factors. Key findings include the coevolution of beta-lactam resistance genes (blaZ, blaI, blaR1), metal resistance genes (cadA, cadC, copB, mco), and plasmid replication genes (repD, repE, repN, pre).
Whole-Genome Sequencing-Based Screening of MRSA in Patients and Healthcare Workers in Public Hospitals in Benin.
The study identified multiple AMR genes and mutations in MRSA isolates from Benin, including mecA, aac(6')-Ie/aph(2")-Ia, aph(3')-IIIa, blaI, blaR1, blaZ, mecI, mecR1, fosB, erm(C), mph(C), msr(A), qacC, dfrG, and dfrS1, along with mutations in glpT, murA, gyrA, and parC associated with resistance to various antibiotics.
Whole genome sequence-based analysis of Staphylococcus aureus isolated from bovine mastitis in Thuringia, Germany.
The study identified multiple AMR genes and mutations in Staphylococcus aureus isolates from bovine mastitis in Thuringia, Germany, including blaZ, blaI, blaR, blaPC, mecA, tetM, tetK, ermA, dfrG, dfrK, ant(6)-Ia, aac(6')-Ie-aph(2"), aadD1, ant(9)-Ia, ant(4')-Ia, aph(2")-Ih, gyrA_S84L, and parC_S80F/Y.
Hybrid Illumina-Nanopore assembly improves identification of multilocus sequence types and antimicrobial resistance genes of Staphylococcus aureus isolated from Vermont dairy farms: comparison to Illumina-only and R9.4.1 nanopore-only assemblies.
The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from Vermont dairy farms, including beta-lactam resistance genes (blaZ, blaI, blaR), tetracycline resistance genes (tet(K), tet(38)), erythromycin resistance genes (erm(T), erm(A)), lincomycin resistance gene (lnu(G)), aminoglycoside resistance genes (aaC3, ant(9)-la), multidrug resistance efflux pumps (lmrS, mepA, mepR, mepB, norA, norB, arlS, arlR, mgrA), and fosfomycin resistance gene (fosB).
NaHCO3 modulates the bla operon and β-lactam susceptibility in borderline oxacillin-resistant Staphylococcus aureus (BORSA).
NaHCO3 modulates the bla operon, reducing β-lactamase production and enhancing susceptibility to penicillin and ampicillin in BORSA strains.
Identification of Novel Staphylococcus aureus Core and Accessory Virulence Patterns in Chronic Rhinosinusitis.
The study identifies various antimicrobial resistance genes in Staphylococcus aureus isolates from patients with chronic rhinosinusitis, including blaI, blaZ, blaPC1, blaR1, erm(T), erm(A), tet(38), mepA, fosB, and ermC, which confer resistance to penicillin, macrolides, lincosamides, streptogramins, tetracycline, and fosfomycin.
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