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blaIND

carbapenem-hydrolyzing metallo-beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaIND

Browse AMR rules for blaIND

Validation StatusSupported

Overview

Mechanism: hydrolyzes carbapenems
Validation Method: cloning in E. coli + MIC testing
Drug Classes: carbapenems, cephalosporins, penicillins, imipenem, meropenem
Organisms: Chryseobacterium indologenes, Chryseobacterium gleum, Escherichia coli
Geographic Location: Argentina
Alleles: 6
Papers: 3
Databases: Reslit

Allele Variants6

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
blaIND-1	Reslit	1	carbapenems	Chryseobacterium indologenes	-	2000	AF219127\|AF219128\|AF219129\|AF219130\|AF219131\|AF219132\|AF219133\|AF219134\|AF219135	-
blaIND-2	Reslit

Papers3

1

Genetic diversity of carbapenem-hydrolyzing metallo-beta-lactamases from Chryseobacterium (Flavobacterium) indologenes.

PMID 11036018 · 2000

The study characterizes four carbapenem-hydrolyzing metallo-beta-lactamases (IND-1, IND-2, IND-3, and IND-4) from Chryseobacterium indologenes, demonstrating their ability to confer resistance to carbapenems.

Gene Information

Gene Name: blaIND
Allele: blaIND-1
Encodes: carbapenem-hydrolyzing metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Chryseobacterium indologenes
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: AF219127|AF219128|AF219129|AF219130|AF219131|AF219132|AF219133|AF219134|AF219135

2

Genetic diversity of carbapenem-hydrolyzing metallo-beta-lactamases from Chryseobacterium (Flavobacterium) indologenes.

PMID 11036018 · 2000

The study characterizes four carbapenem-hydrolyzing metallo-beta-lactamases (IND-1, IND-2, IND-3, and IND-4) from Chryseobacterium indologenes, demonstrating their ability to confer resistance to carbapenems.

Gene Information

Gene Name: blaIND
Allele: blaIND-2
Encodes: carbapenem-hydrolyzing metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Chryseobacterium indologenes
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: AF219127|AF219128|AF219129|AF219130|AF219131|AF219132|AF219133|AF219134|AF219135

3

Genetic diversity of carbapenem-hydrolyzing metallo-beta-lactamases from Chryseobacterium (Flavobacterium) indologenes.

PMID 11036018 · 2000

The study characterizes four carbapenem-hydrolyzing metallo-beta-lactamases (IND-1, IND-2, IND-3, and IND-4) from Chryseobacterium indologenes, demonstrating their ability to confer resistance to carbapenems.

Gene Information

Gene Name: blaIND
Allele: blaIND-3
Encodes: carbapenem-hydrolyzing metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Chryseobacterium indologenes
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: AF219127|AF219128|AF219129|AF219130|AF219131|AF219132|AF219133|AF219134|AF219135

4

Genetic diversity of carbapenem-hydrolyzing metallo-beta-lactamases from Chryseobacterium (Flavobacterium) indologenes.

PMID 11036018 · 2000

The study characterizes four carbapenem-hydrolyzing metallo-beta-lactamases (IND-1, IND-2, IND-3, and IND-4) from Chryseobacterium indologenes, demonstrating their ability to confer resistance to carbapenems.

Gene Information

Gene Name: blaIND
Allele: blaIND-4
Encodes: carbapenem-hydrolyzing metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Chryseobacterium indologenes
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: AF219127|AF219128|AF219129|AF219130|AF219131|AF219132|AF219133|AF219134|AF219135

5

Genetic and biochemical characterization of CGB-1, an Ambler class B carbapenem-hydrolyzing beta-lactamase from Chryseobacterium gleum.

PMID 12183230 · 2002

The study identifies CGB-1, a novel Ambler class B metallo-beta-lactamase from Chryseobacterium gleum, which hydrolyzes various beta-lactam antibiotics including carbapenems, cephalosporins, and penicillins.

Gene Information

Gene Name: blaIND
Allele: blaCGB-1
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenemscephalosporinspenicillins
Organisms Tested In: • Chryseobacterium gleum
• Escherichia coli
Validation Method: cloning and expression in E. coli followed by biochemical and susceptibility testing
Sequence Accession: AF339734

6

Sensitive EDTA-Based Microbiological Assays for Detection of Metallo-β-Lactamases in Nonfermentative Gram-Negative Bacteria.

PMID 16272499 · 2005

The study describes the development of a sensitive microbiological assay (EIM) for detecting metallo-β-lactamases (MBLs) in nonfermentative gram-negative bacteria. It identifies several MBL genes, including bla VIM-11a, bla IMP-7, bla SPM-1, bla L1-like, bla GOB-like, bla IND-like, and bla BcII, which confer resistance to carbapenems.

Gene Information

Gene Name: blaIND
Allele: blaIND-like
Encodes: metallobeta-lactamase
Source Database: Reslit
Mechanism: hydrolyzes carbapenems
Confers Resistance To: imipenemmeropenem
Organisms Tested In: • Chryseobacterium indologenes
Geographic Location: Argentina
Validation Method: PCR