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blaKPC

carbapenem-hydrolyzing beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaKPC

Browse AMR rules for blaKPC

Validation StatusSupported

Overview

Mechanism: hydrolysis of beta-lactam antibiotics
Validation Method: cloning in E. coli and MIC testing
Drug Classes: imipenem, meropenem, extended-spectrum cephalosporins, aztreonam, ertapenem, carbapenems
Organisms: Klebsiella pneumoniae, Escherichia coli, Salmonella enterica serovar Cubana, Klebsiella oxytoca
Geographic Location: Maryland, New York, New York City, United States
Alleles: 3
Papers: 6
Databases: Reslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
blaKPC-1	Reslit	1	imipenem, meropenem +2	Klebsiella pneumoniae +1	-	2001	AF297554	-
blaKPC-2	Reslit

Papers6

1

Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae.

PMID 11257029 · 2001

The study identifies KPC-1, a novel class A carbapenem-hydrolyzing beta-lactamase, as the primary cause of carbapenem resistance in a Klebsiella pneumoniae strain. The gene was cloned and shown to confer resistance to multiple beta-lactam antibiotics.

Gene Information

Gene Name: blaKPC
Allele: blaKPC-1
Encodes: carbapenem-hydrolyzing beta-lactamase
Source Database: Reslit
Confers Resistance To: imipenemmeropenemextended-spectrum cephalosporinsaztreonam
Organisms Tested In: • Klebsiella pneumoniae
• Escherichia coli
Validation Method: cloning in E. coli and MIC testing
Sequence Accession: AF297554

2

Occurrence of newer beta-lactamases in Klebsiella pneumoniae isolates from 24 U.S. hospitals.

PMID 12435685 · 2002

The study identified several beta-lactamases, including bla DHA-1, bla ACT-1, bla FOX-5, bla CMY-2, and bla KPC-2, in Klebsiella pneumoniae isolates from 24 U.S. hospitals. These enzymes confer resistance to various beta-lactam antibiotics.

Gene Information

Gene Name: blaKPC
Allele: blaKPC-2
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of beta-lactam antibiotics
Confers Resistance To: imipenemertapenem
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: United States
Validation Method: PCR and sequencing
Sequence Accession: AF055067|X77455|X91840|U58495|X04730

3

Imipenem resistance in a Salmonella clinical strain due to plasmid-mediated class A carbapenemase KPC-2.

PMID 12654661 · 2003

The study identifies KPC-2, a plasmid-mediated class A carbapenemase, as the cause of imipenem resistance in a Salmonella enterica serotype Cubana isolate.

Gene Information

Gene Name: blaKPC
Allele: blaKPC-2
Encodes: class A carbapenemase
Source Database: Reslit
Confers Resistance To: imipenemcarbapenems
Organisms Tested In: • Salmonella enterica serovar Cubana
• Escherichia coli
Geographic Location: Maryland
Validation Method: cloning in E. coli + carbapenemase bioassay
Sequence Accession: AF481906

4

Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing beta-lactamase KPC-2.

PMID 14638498 · 2003

The study identifies KPC-2, a class A carbapenem-hydrolyzing beta-lactamase, as the primary mechanism of carbapenem resistance in a clinical isolate of Klebsiella oxytoca. KPC-2 was shown to confer resistance to carbapenems, extended-spectrum cephalosporins, and aztreonam when cloned in E. coli.

Gene Information

Gene Name: blaKPC
Allele: blaKPC-2
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis
Confers Resistance To: carbapenemsextended-spectrum cephalosporinsaztreonam
Organisms Tested In: • Klebsiella oxytoca
• Escherichia coli
Validation Method: cloning in E. coli and MIC testing
Sequence Accession: AY210886|AY210887

5

Outbreak of Klebsiella pneumoniae producing a new carbapenem-hydrolyzing class A beta-lactamase, KPC-3, in a New York Medical Center.

PMID 15561858 · 2004

The study identifies a new carbapenem-hydrolyzing class A beta-lactamase, KPC-3, produced by carbapenem-resistant Klebsiella pneumoniae isolates. The enzyme was encoded on a 75-kb plasmid and conferred resistance to carbapenems, cephalosporins, and other beta-lactam antibiotics.

Gene Information

Gene Name: blaKPC
Allele: blaKPC-3
Encodes: carbapenem-hydrolyzing beta-lactamase
Source Database: Reslit
Confers Resistance To: carbapenems
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: New York
Validation Method: PCR amplification and sequencing, plasmid transfer experiments, and antimicrobial susceptibility testing
Sequence Accession: AF395881|AF482468

6

Evaluation of techniques for detection of carbapenem-resistant Klebsiella pneumoniae in stool surveillance cultures.

PMID 16272497 · 2005

The study evaluates techniques for detecting carbapenem-resistant Klebsiella pneumoniae, highlighting the role of the bla KPC-2 gene in conferring resistance to carbapenems.

Gene Information

Gene Name: blaKPC
Allele: blaKPC-2
Encodes: carbapenem-hydrolyzing beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of carbapenems
Confers Resistance To: carbapenems
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: New York City
Validation Method: PCR and sequencing