Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
class A beta-lactamase LAP-1
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaLAP-1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 8 | TICARCILLIN, CEPHALOTHIN +11 |
| France|Vietnam, Mexico|Mexico City, Inner Mongolia|Inner Mongolia, China |
| 2006, 2007, 2022, 2023, 2025 |
| EF026092.1 |
| ABK58097.1 |
| blaLAP-2 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 24 | TICARCILLIN, CEPHALOTHIN +21 | Enterobacter cloacae +15 | UK, Madagascar|Cambodia|Senegal, Vietnam, Cambodia, China, Hangzhou, China, Japan, Europe, Ningxia, China|China, Mexico|Mexico City, Shanghai, China, Bangladesh, Europe|China | 2008, 2013, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | EU159120 | ABV89601.1 |
| blaLAP–2 | Reslit | 1 | Ampicillin, Amoxicillin +6 | Klebsiella pneumoniae | - | 2022 | - | - |
| blaLAP | Reslit | 2 | Cephalosporin, Penicillin | Klebsiella pneumoniae +1 | China | 2023, 2024 | NCBI BioProject: PRJNA931234 | - |
| bla_LAP-2 | Reslit | 1 | - | Klebsiella pneumoniae SM117 | China | 2024 | CP130659|CP130660|CP130661|CP130662|CP130663|CP130664|CP130665|CP130666 | - |
| blaLAP-3 | Reslit | 1 | Amoxicillin, Piperacillin +2 | Klebsiella pneumoniae +1 | China | 2025 | PRJNA1105551|SAMN48696164 | - |
Prevalence and genetic analysis of plasmid-mediated quinolone resistance determinants QnrA and QnrS in Enterobacteriaceae isolates from a French university hospital.
Prevalence and genetic analysis of plasmid-mediated quinolone resistance determinants QnrA and QnrS in Enterobacteriaceae isolates from a French university hospital.
Prevalence and genetic analysis of plasmid-mediated quinolone resistance determinants QnrA and QnrS in Enterobacteriaceae isolates from a French university hospital.
Prevalence and genetic analysis of plasmid-mediated quinolone resistance determinants QnrA and QnrS in Enterobacteriaceae isolates from a French university hospital.
Novel Ambler class A beta-lactamase LAP-1 and its association with the plasmid-mediated quinolone resistance determinant QnrS1.
The study identifies a novel Ambler class A beta-lactamase, LAP-1, and its association with the plasmid-mediated quinolone resistance determinant QnrS1. LAP-1 confers resistance to beta-lactams, while QnrS1 confers resistance to quinolones.
A novel beta-lactamase gene, LAP-2, produced by an Enterobacter cloacae clinical isolate in China.
A novel beta-lactamase gene, LAP-2, produced by an Enterobacter cloacae clinical isolate in China.
A novel beta-lactamase gene, LAP-2, produced by an Enterobacter cloacae clinical isolate in China.
A novel beta-lactamase gene, LAP-2, produced by an Enterobacter cloacae clinical isolate in China.
Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data.
The study identified various AMR genes and mutations in E. coli and K. pneumoniae isolates, including beta-lactamases (bla TEM-1, bla OXA-1, bla CTX-M-15), aminoglycoside-modifying enzymes (aac(6')-Ib-cr, aadA1a, aadA4, aadA5, aph(6')-Id, aph(3')-Ia), and quinolone resistance mutations (gyrA S83L/D87N, parC S80I/E84V). These genes and mutations were validated through whole-genome sequencing and phenotypic testing.
Klebsiella pneumoniae carriage in low-income countries: antimicrobial resistance, genomic diversity and risk factors.
The study identified various AMR genes and mutations in Klebsiella pneumoniae isolates from pregnant women in low-income countries, highlighting the prevalence of multidrug-resistant strains and the role of environmental factors in their carriage.
Colonization with Staphylococcus aureus and Klebsiella pneumoniae causes infections in a Vietnamese intensive care unit.
The study identifies multidrug-resistant Staphylococcus aureus ST188 and various Klebsiella pneumoniae strains with distinct resistance mechanisms, highlighting the role of colonization in causing infections in ICU patients.
Genotypic and Phenotypic Characterization of Antimicrobial Resistance Profiles in Non-typhoidal Salmonella enterica Strains Isolated From Cambodian Informal Markets.
The study identified 17 unique AMR genes in 53% of the 81 S. enterica isolates, including genes encoding resistance to tetracycline, beta-lactam, sulfonamide, quinolone, aminoglycoside, phenicol, and trimethoprim.
Molecular Epidemiological Analysis of ST11-K64 Extensively Drug-Resistant Klebsiella pneumoniae Infections Outbreak in Intensive Care and Neurosurgery Units Based on Whole-Genome Sequencing.
The study identified multiple AMR genes in ST11-K64 XDRKp strains, including beta-lactamases, aminoglycoside resistance genes, and efflux pumps, contributing to extensive drug resistance.
Prevalence and Characteristics of Ceftriaxone-Resistant Salmonella in Children's Hospital in Hangzhou, China.
The study identified various beta-lactamase genes, including bla CTX-M-55, bla CTX-M-65, bla CTX-M-14, bla CTX-M-9, bla CTX-M-64, bla CTX-M-130, bla CMY-2, bla TEM-1, bla TEM-215, bla OXA-1, bla OXA-10, and bla LAP-2, as the primary resistance mechanisms for ceftriaxone-resistant Salmonella. Additionally, the mcr-1 gene was found to confer resistance to colistin.
Antimicrobial Resistance in Salmonella Isolated from Food Workers and Chicken Products in Japan.
The study identified several beta-lactamase genes, including bla CMY-2, bla CTX-M-15, bla CTX-M-55, bla TEM-52B, bla LAT-3, bla LAP-2, and bla TEM-1, which were associated with cefotaxime resistance in Salmonella isolates from food workers and chicken products in Japan.
The Use of Long-Read Sequencing Technologies in Infection Control: Horizontal Transfer of a bla(CTX-M-27) Containing lncFII Plasmid in a Patient Screening Sample.
The study identifies the horizontal transfer of a bla(CTX-M-27) containing lncFII plasmid between an Escherichia coli and a Klebsiella quasipneumoniae isolate, highlighting the role of plasmid-mediated resistance in multidrug-resistant bacteria.
Large-Scale Genomic Epidemiology of Klebsiella pneumoniae Identified Clone Divergence with Hypervirulent Plus Antimicrobial-Resistant Characteristics Causing Within-Ward Strain Transmissions.
The study identified clone divergence in Klebsiella pneumoniae, particularly highlighting the emergence of hypervirulent plus antimicrobial-resistant (hv+AMR) subclones. Key AMR genes such as bla KPC-2, bla CTX-M-65, and others were characterized, along with virulence factors like rmpA, rmpA2, and ybt.
Whole-genome sequencing-based prediction and analysis of antimicrobial resistance in Yersinia enterocolitica from Ningxia, China.
The study identified several AMR genes in Yersinia enterocolitica isolates from Ningxia, China, including aph(6)-Id, aph(3")-Ib, sul2, tet(A), tet(Y), and y56, which confer resistance to various antibiotics such as ampicillin, streptomycin, trimethoprim/sulfamethoxazole, tetracycline, and others. These genes were validated through whole-genome sequencing and resistance gene prediction.
Epidemiological characteristics an outbreak of ST11 multidrug-resistant and hypervirulent Klebsiella pneumoniae in Anhui, China.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Co-Existence of KPC-2, LAP-2, and CTX-M-65 in an ST1469 Multidrug-Resistant Klebsiella pneumoniae Strain in China.
The study identified a multidrug-resistant Klebsiella pneumoniae strain SJ25 co-harboring blaKPC-2, blaCTX-M-65, and blaLAP-2, highlighting the need for continued surveillance of β-lactamase-producing K. pneumoniae.
Genomic and functional characterization of carbapenem-resistant Klebsiella pneumoniae from hospital wastewater.
The study identified the bla KPC-2 gene as a major contributor to carbapenem resistance in Klebsiella pneumoniae isolates from hospital wastewater, demonstrating its successful in vitro transfer through conjugation.
A point mutation in recC associated with subclonal replacement of carbapenem-resistant Klebsiella pneumoniae ST11 in China.
The study identifies multiple AMR genes including blaLAP-2, dfrA-like, qnr-like, sul-like, and tet(A) in hypervirulent and multidrug-resistant Klebsiella pneumoniae ST11 subclones, highlighting their role in the epidemic spread of these strains.
Investigating Possible Interspecies Communication of Plasmids Associated with Transfer of Third-Generation Cephalosporin, Quinolone, and Colistin Resistance Between Simultaneously Isolated Escherichia Coli and Klebsiella Pneumoniae.
The study identified multiple AMR genes in E. coli and K. pneumoniae isolates, including bla CTX-M-14, qnrS1, mcr-1.1, and others, highlighting the role of plasmids in the transfer of resistance genes between species.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Characterization of Beta-Lactam Resistome of Escherichia coli Causing Nosocomial Infections.
The study characterized the beta-lactam resistome of Escherichia coli causing nosocomial infections, identifying several beta-lactamase genes including blaTEM, blaCTX, blaSHV, blaBIL, blaDHA, blaCMY, blaIMP, blaLAP, blaP, blaVIM, and blaKPC, which confer resistance to various beta-lactam antibiotics.
Prevalence, antibiotic resistance and molecular characterization of Staphylococcus aureus in ready-to-eat fruits and vegetables in Shanghai, China.
The study identified several antibiotic resistance genes in Staphylococcus aureus isolates from ready-to-eat fruits and vegetables in Shanghai, China, including genes conferring resistance to beta-lactams, fluoroquinolones, aminoglycosides, lincosamides, and fosfomycin.
Genomic Characteristics of a Carbapenem-Resistant Klebsiella pneumoniae Co-Carrying bla (NDM-5) and bla (KPC-2) Capsular Type KL25 Recovered from a County Level Hospital in China.
The study reports the genomic characteristics of a multidrug-resistant ST11 Klebsiella pneumoniae isolate SM117 with capsular serotype KL25, co-carrying bla NDM-5, two copies of bla KPC-2, and multiple plasmid-borne virulence genes. The isolate shows resistance to all antibiotics except polymyxin.
Multidrug-resistant ST11-KL64 hypervirulent Klebsiella pneumoniae with multiple bla- genes isolated from children's blood.
Comprehensive genomic insights into a highly pathogenic clone ST656 of mcr8.1 containing multidrug-resistant Klebsiella pneumoniae from Bangladesh.
The study identifies multiple beta-lactamase genes (blaLAP-2, blaTEM-1, blaSHV-11, blaOXA-1) and the mcr8.1 gene, which confers resistance to colistin, in a multidrug-resistant K. pneumoniae ST656 isolate from Bangladesh. Additionally, the qacEdelta1 gene, which contributes to resistance against disinfectants and antibiotics, was detected.
Genome-Based Molecular Diversity of Extended-Spectrum beta-lactamase-Producing Escherichia coli From Pigeons in China.
The study identifies multiple extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M, bla TEM, bla OXA, bla LAP, and bla CMY, as well as other antibiotic resistance genes such as mcr-1, mcr-1.1, tet(X4), aadA1, aadA2, aph(6)-Id, aph(3")-Ib, aph(3')-Ia, aph(3')-IIa, aac(3)-IVa, aph(4)-Ia, tet(A), tet(M), sul2, sul3, dfrA14, qnrS1, arr-2, fosA3, cmlA5, floR, mph(A), and lnu(F) in ESBL-producing E. coli isolates from pigeons in China.
Prevalence and antimicrobial resistance of Salmonella enterica isolated from cattle farms in Inner Mongolia.
The study identified several AMR genes in Salmonella enterica isolates from Inner Mongolia, including bla TEM-1, cmlA, tetA, tetB, tetM, aadA2, aph(3')-IIa, aacC4, aac(3)-IIa, sul1, sul3, oqxA, and oqxB, which confer resistance to beta-lactams, chloramphenicol, tetracyclines, aminoglycosides, sulfonamides, and quinolones.
The Impact of Ser165Glu Substitution Within the Ω-Loop on the Hydrolytic Activity of a Novel Ambler Class A beta-lactamase Variant LAP-3.
The study identifies a novel Ambler class A beta-lactamase, LAP-3, which exhibits an expanded hydrolysis spectrum against penicillins, certain cephalosporins, and beta-lactamase inhibitors. The Ser165Glu substitution within the Ω-loop influences the resistance characteristics of LAP-3.
Genomic characterization of Klebsiella pneumoniae clinical isolates from cancer patients: resistance profiles, virulence factors, and sequence typing.
The study identified several AMR genes in K. pneumoniae isolates from cancer patients, including genes conferring resistance to trimethoprim-sulfamethoxazole, tobramycin, levofloxacin, and carbapenems. Key resistance genes included sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA27, aadA16, aadA2, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aph(4)-Ia, ACC(3)-IId, ACC(3)-IIV, AAC(6')-Ib-cr, QnrS1, QnrB17, QnrB20, QnrB4, CTX-M, SHV, TEM, DHA-1, LAP-2, bla_kpc-1, bla_ndm-5, and bla_oxa-10.
Precise species identification and whole-genome sequencing analysis of Enterobacter cloacae complex causing bloodstream infections in China.
The study identified various AMR genes in Enterobacter cloacae complex (ECC) isolates, including bla ACT, bla NDM, and mcr-10, which confer resistance to beta-lactams, carbapenems, and polymyxins, respectively. It also found that E. roggenkampii was the most common species among carbapenem-resistant isolates and showed high resistance to both carbapenems and colistin.
A Monitoring Method to Evaluate the Accumulation of Antimicrobial-Resistance Genes in Gram-Negative Bacteria Distributed in Environmental Water.
The study identified multiple antimicrobial resistance genes (ARGs) in Gram-negative bacteria isolated from environmental water samples, including bla NDM-5, bla CTX-M-27, bla DHA-1, and others, indicating the presence of carbapenem-resistant and extended-spectrum beta-lactamase-producing bacteria in the Vietnamese VAC ecosystem.
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