Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ResLit

blaMOX

beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to blaMOX

AMR Rules

Browse AMR rules for blaMOX

Validation StatusSupported

Overview

Mechanism: AmpC beta-lactamase
Validation Method: PCR, sequencing, and IEF analysis
Drug Classes: cefotaxime, cefoxitin, cefepime, ceftazidime
Organisms: Klebsiella pneumoniae, Escherichia coli
Geographic Location: Greece, Japan, Taiwan
Alleles: 3
Papers: 3
Databases: Reslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
blaCMY-8	Reslit	1	cefotaxime, cefoxitin	Klebsiella pneumoniae	Taiwan	2000	AF167990	-
blaMOX-2	Reslit	1

Papers3

Prevalence of SHV-12 among clinical isolates of Klebsiella pneumoniae producing extended-spectrum beta-lactamases and identification of a novel AmpC enzyme (CMY-8) in Southern Taiwan.

PMID 10817689 · 2000

The study identifies SHV-12 as a prevalent extended-spectrum beta-lactamase in Klebsiella pneumoniae isolates and characterizes a novel AmpC beta-lactamase, CMY-8, which confers resistance to cephalosporins and cephamycins.

Gene Information

Gene Name: blaMOX
Allele: blaCMY-8
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: AmpC beta-lactamase
Confers Resistance To: cefotaximecefoxitin
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: Taiwan
Validation Method: PCR, sequencing, and IEF analysis
Sequence Accession: AF167990

Novel plasmid-encoded class C beta-lactamase (MOX-2) in Klebsiella pneumoniae from Greece.

PMID 12069985 · 2002

The study identifies a novel plasmid-encoded class C beta-lactamase, MOX-2, in a multidrug-resistant Klebsiella pneumoniae isolate from Greece, which exhibits high hydrolytic activity against various beta-lactam antibiotics.

Gene Information

Gene Name: blaMOX
Allele: blaMOX-2
Encodes: class C beta-lactamase
Source Database: Reslit
Confers Resistance To: cefepimecefoxitinceftazidimecefotaxime
Organisms Tested In: • Klebsiella pneumoniae
• Escherichia coli
Geographic Location: Greece
Validation Method: purified enzyme activity and kinetic analysis
Sequence Accession: AJ276453

Characterization of a novel plasmid-mediated cephalosporinase (CMY-9) and its genetic environment in an Escherichia coli clinical isolate.

PMID 12121914 · 2002

The study identifies a novel plasmid-mediated cephalosporinase, CMY-9, which confers resistance to several β-lactam antibiotics, including ceftazidime, cefpirome, cefotaxime, cefminox, cefoxitin, and moxalactam. The gene was cloned and characterized in E. coli.

Gene Information

Gene Name: blaMOX
Allele: blaCMY-9
Encodes: cephalosporinase
Source Database: Reslit
Confers Resistance To: ceftazidimecefotaximecefoxitin
Organisms Tested In: • Escherichia coli
Geographic Location: Japan
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: AB061794