blaOXA

The study identifies OXA-17, a novel extended-spectrum beta-lactamase variant of OXA-10, which confers resistance to various beta-lactam antibiotics including cefotaxime, latamoxef, and cefepime. It also confirms the presence of OXA-10 and OXA-2 beta-lactamases in the isolates.

The study characterizes three novel class D beta-lactamases, OXA-25, OXA-26, and OXA-27, which are associated with carbapenem resistance in clinical isolates of Acinetobacter baumannii.

The study characterizes three novel class D beta-lactamases, OXA-25, OXA-26, and OXA-27, which are associated with carbapenem resistance in clinical isolates of Acinetobacter baumannii.

The study identifies OXA-31 and OXA-1 as beta-lactamases that confer resistance to cefepime and susceptibility to ceftazidime in Pseudomonas aeruginosa.

The study identifies OXA-31 and OXA-1 as beta-lactamases that confer resistance to cefepime and susceptibility to ceftazidime in Pseudomonas aeruginosa.

The study identifies and characterizes OXA-29, a novel class D beta-lactamase from Legionella gormanii, which exhibits broad-spectrum hydrolytic activity against penicillins, cephalosporins, and aztreonam.

The study identifies the oxa-32 gene cassette, which encodes an extended-spectrum variant of OXA-2 beta-lactamase from Pseudomonas aeruginosa, showing resistance to ceftazidime.

The study identified blaTEM-1 and blaOXA-30 as the primary genes responsible for decreased susceptibility to cefpodoxime in E. coli, with additional contributions from porin alterations.

The study identifies OXA-40, a chromosome-encoded carbapenem-hydrolyzing oxacillinase in Acinetobacter baumannii, which shows resistance to inhibition by NaCl and exhibits increased hydrolytic activity against β-lactams upon mutation.

The study identifies OXA-45, an extended-spectrum class 2d' beta-lactamase from Pseudomonas aeruginosa, which confers resistance to aztreonam and oxacillin.

The study identifies the dfrA3b gene, bla CTX-M-2, aacA4, bla OXA-2, and orf513 as significant AMR genes in multidrug-resistant clinical isolates from Argentinean hospitals.

The study identifies two novel oxacillinases, OXA-48 and OXA-47, which confer resistance to imipenem and ceftazidime, respectively, in a multidrug-resistant Klebsiella pneumoniae isolate.

The study identifies two novel oxacillinases, OXA-48 and OXA-47, which confer resistance to imipenem and ceftazidime, respectively, in a multidrug-resistant Klebsiella pneumoniae isolate.

The study characterizes a chromosome-encoded beta-lactamase, OXA-54, from Shewanella oneidensis, which hydrolyzes imipenem and shows high similarity to plasmid-encoded OXA-48 from Klebsiella pneumoniae.

The study identifies several AMR genes, including aacC1, aadA1a, aacA4, blaOXA-20, and blaIMP, which confer resistance to various antibiotics in carbapenem-resistant Acinetobacter baumannii strains.

The study identified various beta-lactamases, including TEM-type, CMY-2, and OXA-type, in amoxicillin-clavulanate-resistant Escherichia coli isolates. Notably, two isolates harbored inhibitor-resistant TEM enzymes (TEM-34 and TEM-122) that conferred resistance to amoxicillin-clavulanate.

The study characterizes the naturally occurring oxacillinase OXA-50 from Pseudomonas aeruginosa, which confers resistance to certain β-lactam antibiotics including ampicillin, ticarcillin, moxalactam, and meropenem.

The study reports the complete nucleotide sequence of a 92-kilobase plasmid, pC15-1a, which harbors the CTX-M-15 extended-spectrum beta-lactamase, along with other resistance genes such as blaOXA-1, blaTEM-1, aac(6')-Ib, aac(3)-II, and tetA. These genes contribute to multidrug resistance in Escherichia coli strains associated with an outbreak in long-term-care facilities in Toronto, Canada.

The study identifies OXA-60, a chromosomal, inducible, and imipenem-hydrolyzing class D beta-lactamase from Ralstonia pickettii, which contributes to resistance against imipenem.

The study identifies OXA-58, a novel class D beta-lactamase, which contributes to carbapenem resistance in Acinetobacter baumannii.

OXA-51, a novel class D carbapenemase, was identified in genetically unrelated carbapenem-resistant Acinetobacter baumannii strains from Argentina. It exhibits high affinity for imipenem and shows less than 63% amino acid identity with existing subgroups of carbapenem-hydrolysing β-lactamases.

The study identifies several AMR genes in multidrug-resistant Salmonella enterica serovar Muenchen isolates from pigs and humans, including blaOXA-30, aadA2, aphA1-Iab, tetA(B), blaTEM, strA, cmlA, and tetA(A). These genes confer resistance to various antibiotics such as ampicillin, amoxicillin-clavulanic acid, streptomycin, kanamycin, tetracycline, chloramphenicol, and gentamicin.

The study identifies a novel trimethoprim resistance gene, dfrA23, on a Salmonella enterica serovar Typhimurium virulence plasmid, along with other resistance genes such as aadB, blaOXA-30, and aadA1.

Seven novel class D beta-lactamases (OXA-64, OXA-65, OXA-66, OXA-68, OXA-69, OXA-70, and OXA-71) were identified in carbapenem-resistant Acinetobacter baumannii isolates from four continents.

Seven novel class D beta-lactamases (OXA-64, OXA-65, OXA-66, OXA-68, OXA-69, OXA-70, and OXA-71) were identified in carbapenem-resistant Acinetobacter baumannii isolates from four continents.

Seven novel class D beta-lactamases (OXA-64, OXA-65, OXA-66, OXA-68, OXA-69, OXA-70, and OXA-71) were identified in carbapenem-resistant Acinetobacter baumannii isolates from four continents.

Seven novel class D beta-lactamases (OXA-64, OXA-65, OXA-66, OXA-68, OXA-69, OXA-70, and OXA-71) were identified in carbapenem-resistant Acinetobacter baumannii isolates from four continents.

Seven novel class D beta-lactamases (OXA-64, OXA-65, OXA-66, OXA-68, OXA-69, OXA-70, and OXA-71) were identified in carbapenem-resistant Acinetobacter baumannii isolates from four continents.

Seven novel class D beta-lactamases (OXA-64, OXA-65, OXA-66, OXA-68, OXA-69, OXA-70, and OXA-71) were identified in carbapenem-resistant Acinetobacter baumannii isolates from four continents.

Seven novel class D beta-lactamases (OXA-64, OXA-65, OXA-66, OXA-68, OXA-69, OXA-70, and OXA-71) were identified in carbapenem-resistant Acinetobacter baumannii isolates from four continents.

OXA-57 is a class D beta-lactamase from Burkholderia pseudomallei that hydrolyzes various beta-lactam antibiotics. Mutations at positions 104 (S104P), 170 (D170N), and 232 (K232N) affect its hydrolytic activity, with S104P showing no activity.

The study identifies and characterizes OXA-46, a new class D beta-lactamase with narrow substrate specificity, encoded by a gene cassette in an integron from a multidrug-resistant Pseudomonas aeruginosa isolate. OXA-46 confers resistance to penicillins and narrow-spectrum cephalosporins.

The study characterizes OXA-69, a chromosomally encoded class D beta-lactamase in Acinetobacter baumannii, which shows limited hydrolytic activity against carbapenems and penicillins.

The study identifies high-level fluoroquinolone-resistant Salmonella enterica serovar Typhimurium isolates with mutations in gyrA (S83F, D87N/G) and parC (S80R), along with resistance genes blaOXA-30, aadA1, dhfr12, aadA2, aac3, catA, and tetRA.