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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
carbapenem-hydrolyzing class D beta-lactamase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaOXA-143 | ResFinder DatabaseReslit | 18 | Carbapenem, MEROPENEM +8 | Acinetobacter baumannii +2 | Brazil, Global|India|Spain, Brazil|Honduras|United States, United Kingdom|Spain|Turkey|Brazil|South Korea|Germany|France|Singapore|Tunisia|global|Europe, Lebanon, Peru, India|France|Italy|Japan|Portugal|Iran|United States|Mexico|Global, global, various countries|Global, Quito, Ecuador|Quito|Ecuador, Europe|Spain |
| 2009, 2012, 2014, 2015, 2016, 2018, 2019, 2020, 2021, 2022, 2024, 2026 |
| GQ861437 |
| - |
| blaOXA-143-like | Reslit | 1 | Meropenem, Imipenem | Acinetobacter baumannii | Brazil | 2016 | LMZH00000000|LMBM00000000|LMBN00000000|LMBO00000000|LMBP00000000|LMBQ00000000 | - |
| bla_OXA-143 | Reslit | 1 | Carbapenem | Acinetobacter baumannii | Europe|Brazil|China|Switzerland|Iran|Puerto Rico|United States | 2016 | - | - |
| blaOXA-143 -like | Reslit | 1 | Ertapenem, Meropenem +1 | Acinetobacter baumannii +1 | Southwest Amazon region|Rondônia|Brazil | 2024 | - | - |
| blaOXA143 | Reslit | 1 | Carbapenem | Escherichia coli +2 | Iran | 2025 | - | - |
OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii.
The study identifies OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii, which confers resistance to carbapenems.
OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii.
The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace.
The paper discusses various virulence factors and mechanisms contributing to the pathogenicity and antibiotic resistance of Acinetobacter baumannii, including biofilm formation, surface polysaccharides, and outer membrane proteins.
Characterization of blaOXA-143 variants in Acinetobacter baumannii and Acinetobacter pittii.
The study characterizes three OXA-143 variants (OXA-231, OXA-253, and OXA-255) in Acinetobacter baumannii and Acinetobacter pittii, demonstrating their ability to confer carbapenem resistance.
OXA beta-lactamases.
The paper characterizes various OXA beta-lactamases, including blaOXA-1, blaOXA-2, blaOXA-3, blaOXA-10, blaOXA-11, blaOXA-23, blaOXA-40, blaOXA-51, blaOXA-58, blaOXA-134a, blaOXA-143, and blaOXA-48, which confer resistance to penicillins, cephalosporins, and carbapenems. These genes were experimentally validated through cloning and MIC testing.
CarbAcineto NP test for rapid detection of carbapenemase-producing Acinetobacter spp.
The study introduces the CarbAcineto NP test, a modified version of the Carba NP test, for the rapid and accurate detection of carbapenemase-producing Acinetobacter spp. The test successfully identifies various carbapenemases including OXA-23, OXA-24/OXA-40, OXA-58, OXA-143, GES-11, GES-14, NDM-1, NDM-2, IMP-1, IMP-4, VIM-4, and SIM-1.
Extrahuman epidemiology of Acinetobacter baumannii in Lebanon.
The study identified a single A. baumannii isolate carrying the blaOXA-143 gene, which confers resistance to carbapenems. Additionally, 34 variants of the blaOXA-51 gene were identified, with 21 being novel.
Antimicrobial Combinations against Pan-Resistant Acinetobacter baumannii Isolates with Different Resistance Mechanisms.
The study identified bla OXA-23-like, bla OXA-143-like, bla OXA-51-like, and bla IMP genes as major resistance mechanisms in pan-resistant Acinetobacter baumannii isolates. These genes conferred resistance to carbapenems, and the study highlighted the synergistic effects of various antibiotic combinations against these isolates.
Clinical and microbiological characteristics of OXA-23- and OXA-143-producing Acinetobacter baumannii in ICU patients at a teaching hospital, Brazil.
The study identified blaOXA-23 and blaOXA-143 as the primary resistance mechanisms in carbapenem-resistant Acinetobacter baumannii (CRAb) isolates from ICU patients in Brazil. These genes were prevalent and associated with high mortality rates.
Insights on the Horizontal Gene Transfer of Carbapenemase Determinants in the Opportunistic Pathogen Acinetobacter baumannii.
The paper discusses the horizontal gene transfer of carbapenemase determinants in Acinetobacter baumannii, focusing on various carbapenemase genes such as bla OXA-23, bla OXA-40, bla OXA-58, bla OXA-143, and bla OXA-235, highlighting their roles in carbapenem resistance and the mechanisms of their dissemination.
Emergence and spread of carbapenem-resistant Acinetobacter baumannii international clones II and III in Lima, Peru.
The study identifies the emergence of carbapenem-resistant Acinetobacter baumannii international clones II and III in Lima, Peru, highlighting the prevalence of OXA-72, OXA-24, OXA-23, OXA-143, and a novel OXA-253 variant. These genes contribute to high resistance rates against carbapenems and other antibiotics.
Synergistic Effect of Ceftazidime-Avibactam with Meropenem against Panresistant, Carbapenemase-Harboring Acinetobacter baumannii and Serratia marcescens Investigated Using Time-Kill and Disk Approximation Assays.
The study investigated the synergistic effects of ceftazidime-avibactam with meropenem against panresistant, carbapenemase-harboring Acinetobacter baumannii and Serratia marcescens. It found that ceftazidime-avibactam was effective against S. marcescens isolates carrying bla KPC-2, while synergy with meropenem was observed in some A. baumannii isolates co-harboring bla OXA-23 and bla OXA-117.
Carbapenemases: Transforming Acinetobacter baumannii into a Yet More Dangerous Menace.
The paper reviews various carbapenemases in Acinetobacter baumannii, including OXA-23, OXA-24, OXA-51, OXA-58, OXA-143, OXA-235, NDM-1, VIM-1, VIM-2, IMP-1, IMP-2, IMP-4, and IMP-5, highlighting their roles in carbapenem resistance.
Molecular epidemiology of antimicrobial resistant microorganisms in the 21th century: a review of the literature.
This review discusses the molecular epidemiology of antimicrobial resistant microorganisms, focusing on multidrug-resistant bacteria involved in healthcare-associated infections. It highlights the prevalence of specific sequence types and clonal complexes across different geographical regions.
Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies of Acinetobacter baumannii.
The paper discusses the antibiotic resistance profiles and molecular mechanisms of Acinetobacter baumannii, highlighting the presence of various beta-lactamases such as blaOXA-23, blaOXA-51, blaOXA-24/40, blaOXA-58, blaOXA-143, blaOXA-235, blaIMP, blaVIM, and blaNDM, as well as aminoglycoside-modifying enzymes like aac(6')-Ib, aph(3')-Ia, and ant(2'')-Ia. It also identifies efflux pumps such as adeABC and tetracycline resistance genes like tet(A).
Acinetobacter baumannii Antibiotic Resistance Mechanisms.
The paper reviews various beta-lactamases and other resistance mechanisms in Acinetobacter baumannii, focusing on their roles in resistance to beta-lactams, aminoglycosides, and other antibiotics.
Carbapenem resistance gene crisis in A. baumannii: a computational analysis.
The study identified several carbapenem resistance genes including blaOXA-51, blaOXA-23, blaOXA-58, blaOXA-24, blaOXA-143, NMD-1, IMP-1, and recA in Acinetobacter baumannii through computational analysis and molecular docking experiments.
Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii with Special Reference to Carbapenemases: A Systematic Review.
The paper reviews the molecular characteristics of carbapenem-resistant Acinetobacter baumannii, focusing on carbapenemases. It identifies several beta-lactamase genes, including OXA-23, OXA-51, OXA-58, VIM, NDM, IMP, KPC, and GES, which confer resistance to carbapenems. The study highlights the role of mobile genetic elements in the dissemination of these resistance genes.
Biodiversity of carbapenem-resistant bacteria in clinical samples from the Southwest Amazon region (Rondônia/Brazil).
The study identified various carbapenemase-encoding genes, including bla KPC -like, bla NDM -like, bla OXA-23 -like, bla OXA-58 -like, bla OXA-143 -like, bla OXA-48 -like, bla SPM -like, bla VIM -like, and bla IMP -like, in carbapenem-resistant bacteria from Rondônia, Brazil.
Carbapenemase genes in clinical and environmental isolates of Acinetobacter spp. from Quito, Ecuador.
The study identified several carbapenemase genes, including bla OXA-23, bla OXA-24, bla OXA-51, bla OXA-72, and bla OXA-143, in clinical and environmental isolates of Acinetobacter spp. from Quito, Ecuador. These genes were found to confer resistance to carbapenems such as imipenem and meropenem.
Carbapenem resistance in gram-negative pathogens in an Iranian hospital: high prevalence of OXA-type carbapenemase genes.
The study identified a high prevalence of OXA-type carbapenemase genes, particularly bla OXA48, bla OXA143, and bla OXA58, among carbapenem-resistant gram-negative bacteria in an Iranian hospital.
Antibacterial activity of enmetazobactam against Acinetobacter spp.: a molecular dissection of mechanism of action and resistance determinants.
Enmetazobactam exhibits intrinsic antibacterial activity against Acinetobacter spp., primarily through its strong affinity for PBP2 and PBP3. The reduced susceptibility to enmetazobactam in A. baumannii is primarily mediated by OXA-type carbapenemases through substrate-assisted catalysis.
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