Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
class A beta-lactamase PEN-A1
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaPEN-A1 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans ATCC 17616 | - | - | AP009386.1 | BAG46675.1 |
| blaPEN-A10 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | PVGE01000083.1 | PRF31748.1 |
| blaPEN-A11 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | PVFR01000052.1 | PRE46797.1 |
| blaPEN-A12 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | JAGSUL010000009.1 | MBR8242798.1 |
| blaPEN-A13 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | PVGS01000019.1 | PRG25577.1 |
| blaPEN-A15 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | PZZC01000063.1 | PTO45445.1 |
| blaPEN-A16 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | JAHPNG010000011.1 | MBU9400921.1 |
| blaPEN-A17 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | PVHL01000015.1 | PRH49453.1 |
| blaPEN-A19 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | PVFO01000062.1 | PRE60969.1 |
| blaPEN-A2 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | JAHPOU010000001.1 | MBU9633967.1 |
| blaPEN-A20 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | FKJW01000005.1 | SAJ99033.1 |
| blaPEN-A21 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | PVGJ01000044.1 | PRF76784.1 |
| blaPEN-A22 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | PVHD01000001.1 | PRH12942.1 |
| blaPEN-A23 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | PVGA01000003.1 | PRF03901.1 |
| blaPEN-A24 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | PVGQ01000030.1 | PRG23231.1 |
| blaPEN-A25 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | PVGL01000065.1 | PRF70551.1 |
| blaPEN-A26 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | PVFS01000052.1 | PRE61420.1 |
| blaPEN-A27 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | PVFV01000050.1 | PRF07752.1 |
| blaPEN-A28 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | FKJT01000002.1 | SAJ87944.1 |
| blaPEN-A29 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | PVFY01000023.1 | PRF24721.1 |
| blaPEN-A3 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | PVFL01000048.1 | PRE15547.1 |
| blaPEN-A30 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | PVGF01000057.1 | PRF30389.1 |
| blaPEN-A33 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | CP013431.1 | AOJ95146.1 |
| blaPEN-A35 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | PVHF01000072.1 | PRG97828.1 |
| blaPEN-A38 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | PVGW01000007.1 | PRG97326.1 |
| blaPEN-A5 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | PVFH01000008.1 | PRE07490.1 |
| blaPEN-A6 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | PVGD01000114.1 | PRF35301.1 |
| blaPEN-A7 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | JAHPNU010000001.1 | MBU9498712.1 |
| blaPEN-A8 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | CP008729.1 | AIO74009.1 |
| blaPEN-A9 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | - | CP033747.1 | AYZ01688.1 |
| blaPEN-A4 | Reference Gene Catalog | 1 | BETA-LACTAM | Burkholderia multivorans | - | 2009 | CADFDG010000004.1 | - |
| blaPenA | Reslit | 4 | ampicillin, cephalothin +8 | Escherichia coli +3 | USA|Global, France | 2013, 2017, 2024 | 3W4Q|3W4P|3W4O | - |
| blaPEN-A31 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | 2015 | JFHP01000003.1 | KHS16526.1 |
| blaPENA-34 | Reslit | 1 | ceftriaxone | Neisseria gonorrhoeae | United States|Japan|Australia|Canada|Philippines | 2021 | CP012026.1|SRR969380|PRJNA416507|PRJNA415047 | - |
| blaPENA-72 | Reslit | 1 | ceftriaxone | Neisseria gonorrhoeae | United States|Japan|Australia|Canada|Philippines | 2021 | CP012026.1|SRR969380|PRJNA416507|PRJNA415047 | - |
| blaPEN-A18 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | 2022 | CP090717.1 | UQO71494.1 |
| blaPEN-A32 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | 2022 | JAKFAI010000002.1 | MCO1416124.1 |
| blaPEN-A34 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | 2022 | CP090735.1 | UQO45168.1 |
| blaPEN-A37 | Card DatabaseReference Gene Catalog | 2 | BETA-LACTAM | Burkholderia multivorans | - | 2022 | CP090776.1 | UQN71920.1 |
Naturally occurring Class A ss-lactamases from the Burkholderia cepacia complex.
Research Article
Insights into beta-lactamases from Burkholderia Species, Two Phylogenetically Related yet Distinct Resistance Determinants.
Research Article
The study identifies and characterizes two beta-lactamases, PenA from B. multivorans and PenI from B. pseudomallei, which show distinct resistance profiles against various β-lactam antibiotics.
Draft Genome Sequences of Two Burkholderia multivorans Sequential Isolates from a Chronic Lung Infection of a Cystic Fibrosis Patient.
Research Article
Draft Genome Sequences of Two Burkholderia multivorans Sequential Isolates from a Chronic Lung Infection of a Cystic Fibrosis Patient.
Research Article
Class A Carbapenemases: Mechanisms of Action and Resistance
Review
The paper characterizes various class A carbapenemases, including KPC, GES, SME, NmcA, FRI-1, BIC-1, SFC-1, and PenA, highlighting their roles in conferring resistance to carbapenems and other β-lactam antibiotics.
Overcoming an Extremely Drug Resistant (XDR) Pathogen: Avibactam Restores Susceptibility to Ceftazidime for Burkholderia cepacia Complex Isolates from Cystic Fibrosis Patients.
Research Article
Avibactam restores susceptibility to ceftazidime in multidrug-resistant and extremely drug-resistant Burkholderia cepacia complex isolates by inhibiting the class A carbapenemase PenA.
Phylogenomic analysis reveals persistence of gonococcal strains with reduced-susceptibility to extended-spectrum cephalosporins and mosaic penA-34.
Research Article
The study identifies mosaic penA alleles, specifically penA-34 and penA-72, as responsible for reduced susceptibility to extended-spectrum cephalosporins in Neisseria gonorrhoeae strains.
Phylogenomic analysis reveals persistence of gonococcal strains with reduced-susceptibility to extended-spectrum cephalosporins and mosaic penA-34.
Research Article
The study identifies mosaic penA alleles, specifically penA-34 and penA-72, as responsible for reduced susceptibility to extended-spectrum cephalosporins in Neisseria gonorrhoeae strains.
Susceptibility of Burkholderia cepacia Complex to Ceftazidime/Avibactam and Standard Drugs of Treatment for Cystic Fibrosis Patients.
Research Article
Susceptibility of Burkholderia cepacia Complex to Ceftazidime/Avibactam and Standard Drugs of Treatment for Cystic Fibrosis Patients.
Research Article
Susceptibility of Burkholderia cepacia Complex to Ceftazidime/Avibactam and Standard Drugs of Treatment for Cystic Fibrosis Patients.
Research Article
Susceptibility of Burkholderia cepacia Complex to Ceftazidime/Avibactam and Standard Drugs of Treatment for Cystic Fibrosis Patients.
Research Article
Susceptibility of Burkholderia cepacia Complex to Ceftazidime/Avibactam and Standard Drugs of Treatment for Cystic Fibrosis Patients.
Research Article
Susceptibility of Burkholderia cepacia Complex to Ceftazidime/Avibactam and Standard Drugs of Treatment for Cystic Fibrosis Patients.
Research Article
Susceptibility of Burkholderia cepacia Complex to Ceftazidime/Avibactam and Standard Drugs of Treatment for Cystic Fibrosis Patients.
Research Article
Susceptibility of Burkholderia cepacia Complex to Ceftazidime/Avibactam and Standard Drugs of Treatment for Cystic Fibrosis Patients.
Research Article
National Cohort of Compassionate Use of Meropenem-Vaborbactam: No Benefit over Meropenem for Pseudomonas aeruginosa.
Research Article
The study found that vaborbactam did not provide any advantage in treating P. aeruginosa infections, as the addition of vaborbactam to meropenem did not modify the MIC. However, MEM-VAB was effective against KPC-3-producing K. pneumoniae and B. multivorans, significantly reducing the MIC of meropenem.
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