Browse AMR Genes

Explore antimicrobial resistance genes from the literature

blaPER

serine-beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaPER

Browse AMR rules for blaPER

Validation StatusSupported

Overview

Mechanism: extended-spectrum beta-lactamase
Validation Method: PCR and sequencing
Drug Classes: ceftazidime, cefepime, aztreonam, piperacillin, imipenem, meropenem, cephalosporins, cefotaxime, cephalothin, ampicillin
Organisms: Pseudomonas aeruginosa, Vibrio cholerae O1 El Tor, Acinetobacter baumannii, Alcaligenes faecalis, Escherichia coli
Geographic Location: Argentina, Europe, Italy, South Korea
Alleles: 2
Papers: 4
Databases: Reslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
blaPER-1	Reslit	3	ceftazidime, cefepime +7	Pseudomonas aeruginosa +3	Europe, South Korea, Italy	2001, 2002, 2005	AJ627643	-
blaPER-2

Papers4

1

Multidrug-resistant Pseudomonas aeruginosa producing PER-1 extended-spectrum serine-beta-lactamase and VIM-2 metallo-beta-lactamase.

PMID 11747713 · 2001

The study identifies the presence of blaPER-1 and blaVIM-2 genes in a multidrug-resistant Pseudomonas aeruginosa isolate, which confer resistance to multiple beta-lactam antibiotics.

Gene Information

Gene Name: blaPER
Allele: blaPER-1
Encodes: serine-beta-lactamase
Source Database: Reslit
Confers Resistance To: ceftazidimecefepimeaztreonampiperacillinimipenemmeropenem
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: Europe
Validation Method: PCR and sequencing

2

Plasmidic extended-spectrum beta-lactamases in Vibrio cholerae O1 El Tor isolates in Argentina.

PMID 11959583 · 2002

The study identifies the presence of plasmidic extended-spectrum beta-lactamases (ESBLs) in Vibrio cholerae O1 El Tor isolates in Argentina, specifically CTX-M-type and PER-2-type ESBLs.

Gene Information

Gene Name: blaPER
Allele: blaPER-2
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: extended-spectrum beta-lactamase
Confers Resistance To: cephalosporinsceftazidimecefotaxime
Organisms Tested In: • Vibrio cholerae O1 El Tor
Geographic Location: Argentina
Validation Method: PCR-RFLP analysis and isoelectric focusing

3

The resistance mechanisms of b-lactam antimicrobials in clinical isolates of Acinetobacter baumannii.

PMID 12164097 · 2002

The study identified blaTEM-1 and blaPER-1 beta-lactamase genes as contributors to beta-lactam resistance in Acinetobacter baumannii. The chromosomal AmpC beta-lactamase was found to play a significant role in resistance, while changes in outer membrane proteins were linked to carbapenem resistance.

Gene Information

Gene Name: blaPER
Allele: blaPER-1
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of beta-lactam antibiotics
Confers Resistance To: aztreonam
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: South Korea
Validation Method: PCR and sequencing

4

Tn5393d, a complex Tn5393 derivative carrying the PER-1 extended-spectrum beta-lactamase gene and other resistance determinants.

PMID 16048938 · 2005

The study identifies Tn5393d, a complex transposon carrying the PER-1 extended-spectrum beta-lactamase gene and the aphA6b aminoglycoside phosphotransferase gene, which confer resistance to multiple beta-lactam and aminoglycoside antibiotics.

Gene Information

Gene Name: blaPER
Allele: blaPER-1
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: ceftazidimecefotaximeaztreonamcephalothinpiperacillinampicillin
Organisms Tested In: • Alcaligenes faecalis
• Escherichia coli
Geographic Location: Italy
Validation Method: cloning in E. coli + susceptibility testing
Sequence Accession: AJ627643