The study identifies the PER-1 extended-spectrum beta-lactamase as a significant factor in a multidrug-resistant Pseudomonas aeruginosa outbreak, demonstrating its role in resistance to ceftazidime, cefepime, and aztreonam.

The study identifies the presence of blaPER-1 and blaVIM-2 genes in a multidrug-resistant Pseudomonas aeruginosa isolate, which confer resistance to multiple beta-lactam antibiotics.

The study identifies the presence of plasmidic extended-spectrum beta-lactamases (ESBLs) in Vibrio cholerae O1 El Tor isolates in Argentina, specifically CTX-M-type and PER-2-type ESBLs.

The study identified blaTEM-1 and blaPER-1 beta-lactamase genes as contributors to beta-lactam resistance in Acinetobacter baumannii. The chromosomal AmpC beta-lactamase was found to play a significant role in resistance, while changes in outer membrane proteins were linked to carbapenem resistance.

The study identified SHV- and CTX-M-type extended-spectrum beta-lactamases as the most prevalent in Klebsiella pneumoniae bloodstream isolates from seven countries, highlighting their significance in antibiotic resistance.

The study identified multidrug-resistant Pseudomonas aeruginosa isolates producing the PER-1 extended-spectrum beta-lactamase in northern Italy, highlighting the presence of this resistance mechanism in multiple hospitals and its association with nosocomial outbreaks.

The study characterizes the genetic environment of the blaPER-1 gene, identifying it as part of a composite transposon and highlighting its expression driven by promoter sequences in IS Pa12.

The study identifies Tn5393d, a complex transposon carrying the PER-1 extended-spectrum beta-lactamase gene and the aphA6b aminoglycoside phosphotransferase gene, which confer resistance to multiple beta-lactam and aminoglycoside antibiotics.

The study identified the PER-1 extended-spectrum beta-lactamase as a significant contributor to multidrug resistance in Pseudomonas aeruginosa bloodstream infections, leading to poor treatment outcomes and increased hospital costs.

The study reports the emergence of PER-2 and VEB-1a beta-lactamases in Acinetobacter baumannii strains in the Americas, along with the identification of blaOXA-58, a carbapenemase gene.

The study identified multiple antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates, including bla ADC, bla OXA-69-like, bla OXA-23-like, bla OXA-58-like, bla TEM, bla PER, aacC1, aacC2, aadA1, aadB, and aphA6, which confer resistance to various antibiotics such as ceftazidime, cefepime, imipenem, meropenem, ampicillin, ampicillin-sulbactam, gentamicin, tobramycin, streptomycin, spectinomycin, amikacin, kanamycin, and neomycin.

The study characterizes the PER-2 beta-lactamase, which confers resistance to cephalosporins, and identifies its genetic environment, including an IS Pa12/IS 1387a insertion sequence.

The study reports the first ESBL-producing Acinetobacter baumannii isolate resistant to carbapenems, carrying the blaPER-1 gene, which confers resistance to ceftazidime and ticarcillin.

The study identifies the PER-1 extended-spectrum beta-lactamase and OXA-2 and OXA-74 oxacillinases in Pseudomonas aeruginosa isolates from Warsaw, Poland, contributing to beta-lactam resistance.

The study identified blaOXA-23 as the most prevalent carbapenemase in carbapenem-resistant Acinetobacter spp. in Chinese hospitals, along with blaOXA-51, blaOXA-58, blaOXA-66, and blaPER-1. These genes contribute to resistance against various β-lactam antibiotics.

The study reports the first detection of PER-1-producing Pseudomonas aeruginosa and Acinetobacter baumanii strains, as well as VIM-2-producing Pseudomonas aeruginosa in Hungary. These strains exhibited resistance to multiple beta-lactam antibiotics.

The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-1, bla CTX-M-2, bla CTX-M-5, bla CTX-M-15, bla CTX-M-22, bla CTX-M-28, bla SHV-5, bla SHV-12, bla TEM-1, bla OXA-1, bla OXA-2, bla OXA-5, bla PER-1, bla ACT-1, bla MIR-1, bla CMY-2, bla FOX-1, bla DHA-1, and bla KPC-2, in Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates.

The study identifies PER-6, a novel extended-spectrum beta-lactamase from Aeromonas allosaccharophila, which confers resistance to various beta-lactam antibiotics including ceftazidime, cefotaxime, cefepime, imipenem, meropenem, and ertapenem.

The study identified various clavulanic acid-inhibited extended-spectrum beta-lactamases (ESBLs) in Aeromonas spp. from the Seine River, including blaVEB-1a, blaSHV-12, blaPER-1, blaPER-6, blaTLA-2, and blaGES-7, highlighting the diversity of ESBLs in aquatic environments.

The study identified various clavulanic acid-inhibited extended-spectrum beta-lactamases (ESBLs) in Aeromonas spp. from the Seine River, including blaVEB-1a, blaSHV-12, blaPER-1, blaPER-6, blaTLA-2, and blaGES-7, highlighting the diversity of ESBLs in aquatic environments.

The study identifies PER-7, a novel extended-spectrum beta-lactamase in Acinetobacter baumannii, which exhibits increased hydrolytic activity against broad-spectrum cephalosporins and aztreonam compared to PER-1.

The study identified several beta-lactamase genes, including blaPER-1, blaOXA-28, and blaOXA-19, which contribute to multidrug resistance in Pseudomonas aeruginosa isolates from hospitals in eastern France.

The study identified bla PER-3 as an extended-spectrum beta-lactamase gene in two Aeromonas caviae isolates, which conferred resistance to cephalosporins.

The study identified the ESBL PER-1 and the MBL IMP-29 in Pseudomonas aeruginosa isolates from hospital wastewater and treated water within the WWTP.

The study identifies the bla CTX-M-2, qnrB10, and bla PER-2 genes as responsible for multidrug resistance in Serratia marcescens isolates during an outbreak following colistin administration in a hospital setting.

The study identifies various beta-lactamase genes, including CTX-M-15, CTX-M-14, CTX-M-9, SHV-12, SHV-5, TEM-1, VEB-1, GES-1, GES-5, GES-11, PER-1, OXA-48, NDM-1, VIM-2, OXA-23, OXA-40, OXA-58, and OXA-181, which confer resistance to β-lactam antibiotics in Gram-negative pathogens from the Arabian Peninsula.

The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.

The study identifies blaPER-1, an extended-spectrum beta-lactamase gene, in a complex genetic context involving miniature inverted-repeat transposable elements (MITEs) in Acinetobacter johnsonii strain XBB1.

The study identified blaPER-1 and blaVEB-1 genes as significant contributors to extended-spectrum beta-lactamase (ESBL) production in Pseudomonas aeruginosa isolates from western Iran, highlighting the high prevalence of multidrug-resistant strains.

The study identifies multiple antibiotic resistance genes in Acinetobacter baumannii clinical isolates, including blaOXA-23, aacC1, aadA1, strA, strB, tetA(B), tetR(B), sul2, ampC, per-1, and blaOXA-66, which contribute to multidrug resistance.

The study identified the presence of CTX-M and PER-1 extended-spectrum beta-lactamases in Pseudomonas aeruginosa isolates from patients with lower respiratory tract infections.

The study identified various AMR genes, including bla TEM, dfr, strB, tet(A), and tet(B), in Gram-negative fecal bacteria from volunteers treated with amoxicillin, minocycline, or placebo. The prevalence of these genes increased significantly in the amoxicillin-treated group.

The study identified blaTEM-116, blaVEB-1, and blaPER-1 as the most prevalent ESBL genes in Pseudomonas aeruginosa isolates from Zahedan, Iran, with blaTEM being 100% prevalent.

The study reports the detection of the PER-1 extended-spectrum beta-lactamase in a non-O1, non-O139 Vibrio cholerae strain from China, highlighting the mobilization of blaPER-1 through an ISCR1 element and a conjugative IncA/C plasmid.

The study identified the emergence of the integron-borne blaPER-1 gene, which confers resistance to cephalosporins in Gram-negative bacteria, highlighting its lateral transferability via diverse plasmid incompatibility groups.

The paper characterizes various class A beta-lactamases, including TEM-1, GIL-1, OXY, CTX-M, SFO-1, CARBA, GES, PER-1, and VEB-1, highlighting their roles in conferring resistance to β-lactam antibiotics such as penicillins, cephalosporins, and carbapenems.

The study characterized β-lactamase genes in baseline pathogens from patients enrolled in phase 2 trials for ceftazidime-avibactam, identifying CTX-M-14, CTX-M-15, OXA-1, TEM-1, OXA-1/30, SHV-12, ACC-4, CMY-42, NDM-1, VIM-2, PER-1, and OXA-23 as key resistance determinants against ceftazidime.

The study identified the presence of blaPER-1 and blaVEB-1 beta-lactamase genes among Pseudomonas aeruginosa isolates from ICU patients in South West Iran, contributing to resistance against ceftazidime and cefotaxime.

The study identifies multiple AMR genes and mutations in Pseudomonas aeruginosa, including aadA1, aadA6, aacA4, aacA7, aacA5, blaOXA-2, blaOXA-4, blaVIM-1, blaVIM-2, blaGIM-2, blaIMP-1, blaIMP-7, blaPER-1, blaCTX-M-3, ampC, gyrA (T83I), and parC (S87L/W), which are associated with resistance to various antibiotics such as tobramycin, ceftazidime, meropenem, and ciprofloxacin.

The study identified that abaI and csuE-positive Acinetobacter baumannii strains are associated with higher antimicrobial resistance to 14 types of antibiotics, including amikacin, ampicillin/sulbactam, cefepime, cefoperazone/sulbactam, cefotaxime, ceftazidime, ciprofloxacin, gentamicin, imipenem, meropenem, piperacillin/tazobactam, tetracycline, cotrimoxazole (SMZco), and levofloxacin.

The study identified several beta-lactamase genes (blaPER-2, blaOXA-58, blaTEM-1, and blaOXA-498) along with other resistance determinants such as strA, strB, ereA, sul1, and aacC2 in the Acinetobacter johnsonii strain Aj2199. These genes contribute to resistance against various antibiotics, highlighting the presence of horizontal genetic transfer in this strain.

The study identifies NDM-1 as a major carbapenem resistance determinant in Acinetobacter spp. causing neonatal sepsis, along with other beta-lactamases like OXA-23-like, OXA-58-like, PER-1, VEB-2, and aminoglycoside modifying enzymes such as aac(6')-Ib, aac(6')-Ib-cr, and armA.

The study identified multiple AMR genes in Aeromonas sp. ARM81, including three aminoglycoside resistance genes (aph(3'-VIb), aph(3''-Ib), and aph(6)-Id), a tetracycline efflux gene (tetA(E)), and two beta-lactamase genes (blaPER-1 and blaMOX-12).

Avibactam inactivates the PER-2 beta-lactamase, restoring susceptibility to ceftazidime, ceftaroline, and aztreonam in Enterobacteriaceae producing blaPER-2.

The study identified the presence of extended-spectrum beta-lactamase (ESBL)-producing Pseudomonas aeruginosa in camel meat in Egypt, highlighting the potential risk of transmission to humans. The ESBL genes bla PER-1, bla CTX-M, bla SHV, and bla TEM were detected in the isolates.

The study identified the presence of various beta-lactamase genes (blaTEM, blaCTX-M, blaSHV, blaPER, blaGES, blaVIM, blaIMP, blaOXA, blaKPC) and integron genes (intI, intII, intIII) in clinical strains of Klebsiella pneumoniae, highlighting the prevalence of multidrug resistance.

The study reports the first outbreak of multidrug-resistant Providencia rettgeri isolates co-producing NDM-1 carbapenemase and PER-1 extended-spectrum beta-lactamase in Korea.

The study identifies the prevalence of extended-spectrum beta-lactamases (ESBLs) and AmpC beta-lactamases in cephalosporin-resistant Acinetobacter baumannii isolates in Egypt, highlighting the co-production of blaTEM, blaPER, blaSHV, blaVEB, and blaADC genes contributing to beta-lactam resistance.

The study demonstrates the transfer of antibiotic resistance genes, including bla OXA-23, bla PER-1, and aphA6, via conjugative plasmids and class 1 integrons in Acinetobacter baumannii.

The study characterized various AMR genes in Acinetobacter spp. including blaPER-1, blaTEM-1D, blaADC-31, blaOXA-82, aac(3')-Ia, aac(6')-Il, aph(3')-Ic, strAB, and others. Mutations in gyrA and parC were associated with fluoroquinolone resistance. Overexpression of efflux pumps like adeB and adeJ contributed to multidrug resistance.

The study developed and validated 85 PCR assays to detect 79 AMR genes and mutations associated with resistance across 10 antimicrobial classes, focusing on E. coli. The assays showed high concordance with sequencing and phenotypic susceptibility testing, demonstrating their potential for AMR surveillance in E. coli isolates and direct stool specimens.

The study identified antibiotic resistance genes such as aac(6')-Ib, bla CTX-M-2, bla PER-2, pAmp CDHA, and pAmp CFOX in bacterial isolates from freshwater samples in Antarctica, highlighting the impact of human activity on the local microbiota and the presence of resistance genes in areas under different levels of human and animal influence.

The study identified several beta-lactamase and carbapenemase genes, including bla OXA10, bla VIM, bla OXA48, bla OXA2, bla CTX-M, bla PER, and bla NDM, which contribute to resistance against ceftazidime-avibactam and ceftolozane-tazobactam in Pseudomonas aeruginosa isolates from Iran.

The study identified several β-lactamase and carbapenemase genes, including bla KPC, bla OXA-48, bla NDM, bla CTX-M-15, bla SHV, bla OXA-1, bla TEM, and bla PER-1, which confer resistance to cephalosporins and carbapenems in Enterobacteriaceae isolated from fish, water, and workers at integrated agriculture-aquaculture systems in Egypt.

The paper reviews the diversity and characteristics of plasmids in Acinetobacter species, particularly highlighting the presence of various beta-lactamase genes (blaOXA-23, blaOXA-58, blaOXA-24, blaPER-1, blaADC-25), aminoglycoside resistance genes (aadB, aphA6), tetracycline resistance gene (tet(39)), macrolide resistance genes (mph(E), msr(E)), sulfonamide resistance gene (sul2), and other resistance genes (bcr). These genes are primarily found on plasmids and contribute to multidrug resistance in clinical isolates.

The study identified several AMR genes and mutations in Acinetobacter baumannii, including beta-lactamases like blaOXA-23, blaOXA-64, and blaOXA-235, as well as aminoglycoside resistance genes like aadA1 and AAC(3)-Ia. It also found a gyrA S82L mutation associated with quinolone resistance.

The study identifies multiple mechanisms of resistance to ceftolozane/tazobactam in Pseudomonas aeruginosa, including the production of extended-spectrum beta-lactamases (ESBLs) and carbapenemases, overproduction of the intrinsic cephalosporinase PDC, and mutations in regulatory and peptidoglycan recycling genes.

The study identified bla PER-1 and bla VEB-1 genes as the most prevalent ESBL-encoding genes in Pseudomonas aeruginosa isolates from burn patients in Tehran, Iran.

The study identifies blaCTX-M2, blaPER, and blaTEM as the primary ESBL genes in MDR P. aeruginosa isolates from burn patients in Algeria, highlighting the spread of these resistance genes in the region.

The paper reviews various beta-lactamases and other resistance mechanisms in Acinetobacter baumannii, focusing on their roles in resistance to beta-lactams, aminoglycosides, and other antibiotics.

The study identified several carbapenem resistance genes, including blaVEB, blaPER, blaNDM, blaKPC, blaIMP, blaVIM, blaOXA-48, and blaOXA-23, in carbapenem-resistant Pseudomonas aeruginosa isolates.

The study found that anaerobic digestion of dairy manure significantly reduced the abundance of antibiotic resistance genes, including various ESBL genes such as bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, and bla PER-1, as well as other resistance genes like aac(6')-Ib-cr, aph(3')-Ib, aph(6)-Id, bla OXA-1, catB4, dfrA1, floR, lnu(G), sul2, aadA2, mph(E), msr(E), tet(C), tet(E), and tet(X).

The study identified the presence of blaOXA-1, blaTEM-1, blaGES-1, blaCTX-M-15, and blaPER-1 genes in ESBL-producing Acinetobacter baumannii isolates in Qazvin, Iran. These genes were found to confer resistance to various β-lactam antibiotics.

The study identified several antibiotic resistance genes in Acinetobacter baumannii, including clmA, pbp1, pbp3, blaPER-7, aac(6a)-Ib, ant(2n)-Ia, armA, aphA6, sul1, and arr2, which were upregulated or downregulated in response to human serum albumin (HSA) and human serum (HS).

The study identified bla VIM and bla OXA-23 genes as significant contributors to carbapenem resistance in multidrug-resistant Acinetobacter baumannii isolates. Additionally, biofilm-related genes omp A, bap, and csu E were associated with enhanced biofilm formation.

The study reports a pandrug-resistant Acinetobacter pittii isolate (17-84) carrying multiple resistance genes including blaOXA-58, blaPER-1, aph(3')-VIb, aac(3')-IId, sul2, msr(E), and mph(E), along with mutations in gyrA, gyrB, parC, and pmrC contributing to resistance against various antibiotics.

The study identifies the presence of blaCTX-M-15, blaPER-1, and blaTEM-1 genes in Citrobacter spp. isolates, which confer resistance to various beta-lactam antibiotics.

The study identified bla AmpC, bla PER-1, and oprD as key genes contributing to resistance in non-MBL-producing XDRPA strains, highlighting the importance of these mechanisms in CZA and IPM resistance.

GLO1 contributes to drug resistance in Escherichia coli by upregulating PER-type beta-lactamase expression.

The paper reviews β-lactam antibiotics and beta-lactamase enzymes inhibitors, focusing on the mechanisms of resistance mediated by beta-lactamases such as TEM-1, SHV-1, KPC-2, OXA-48, and NDM-1, and highlights the need for new inhibitors to combat carbapenem-resistant bacteria.

This study characterizes four groups of chromosome-borne accessory genetic elements (AGEs) in Providencia, highlighting the diversity and complexity of multidrug resistance (MDR) regions within these elements. It identifies numerous drug resistance genes, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and others, contributing to the understanding of AMR mechanisms in Providencia.

The study identified a variety of AMR genes in Acinetobacter baumannii clinical isolates from Egypt, including novel variants such as blaADC-258 and resistance islands like RI-PER-7. Key findings include the prevalence of blaOXA-23, blaTEM-1, and armA, along with multiple resistance determinants associated with mobile genetic elements.

The study identified the high prevalence of bla(VEB), bla(GES), and bla(PER) genes in beta-lactam-resistant Pseudomonas aeruginosa clinical isolates, highlighting their significant role in resistance to various beta-lactam antibiotics.

The study identified colistin-resistant Acinetobacter baumannii isolates with resistance genes including bla OXA-23, bla NDM-1, lps B, and various efflux pumps. These isolates exhibited extensive drug resistance (XDR) and were associated with sequence types ST1 and ST2.

The study identifies multiple AMR genes and mutations contributing to CZA resistance in Enterobacterales and P. aeruginosa, including MBLs, blaKPC, blaVIM, blaIMP, blaNDM, blaSPM-1, and various mutations in genes related to efflux pumps, porins, and beta-lactamases.

The study identifies multiple AMR genes and mutations contributing to CZA resistance in Enterobacterales and P. aeruginosa, including MBLs, blaKPC, blaVIM, blaIMP, blaNDM, blaSPM-1, and various mutations in genes related to efflux pumps, porins, and beta-lactamases.

The study identified multiple antimicrobial resistance genes in Aeromonas caviae isolates from extra-intestinal infections, including blaMOX, blaPER-3, blaOXA, blaNDM, blaCphA, qnrS2, qnrVC, aac(6')-Ib-cr, tet(A), tet(E), tet(31), dfrA1, dfrA12, dfrA14, dfrA15b, floR, catB3, catII, and catI, which confer resistance to various antibiotics such as cephalosporins, carbapenems, fluoroquinolones, tetracyclines, trimethoprim, and chloramphenicol.

The study identified several beta-lactamase genes, including bla SHV-2a, bla CTX-M-28, bla OXA-677, bla PER, and bla VEB-2, which contribute to multidrug resistance in Pseudomonas aeruginosa isolates from Basra, Iraq.

The study identified blaIMP-45 as a major determinant of meropenem resistance in P. aeruginosa, and mutations in oprD, mexR, nalD, and armR were associated with meropenem resistance.

The study identifies multiple AMR genes and mutations contributing to CZA and IPM resistance in P. aeruginosa, including blaPER-1, blaPDC-421, blaOXA-2, blaOXA-50, blaOXA-904, blaOXA-905, blaOXA-913, blaOXA-914, and blaCARB-2, along with mutations in dacB, ampD, ampE, ampR, oprD, nalC, nalD, mexR, and mexZ.

The study identified various beta-lactamase genes, including bla GES, bla VEB-9, bla PER-1, bla NDM-1, bla VIM-2, bla IMP-15, and bla IMP-18, as well as PDC variants like bla PDC-3 and bla PDC-19A, which contribute to resistance against ceftolozane-tazobactam and ceftazidime-avibactam in multidrug-resistant and carbapenem-resistant Pseudomonas aeruginosa isolates.

The study identifies five β-lactamase genes (bla(NDM-1), bla(OXA-23), bla(OXA-64), bla(PER-7), and bla(ADC-57)) in a clinical isolate of Acinetobacter baumannii from Egypt, highlighting the co-existence of multiple carbapenem resistance mechanisms.

The study characterizes the AMR genes bla OXA-58, bla PER-1, and bla NDM-1 in a carbapenem-resistant Acinetobacter johnsonii strain, highlighting their roles in resistance to multiple antibiotics.

The study characterizes various AMR genes in carbapenem-resistant Acinetobacter baumannii isolates, including blaOXA-23, blaPER-7, blaGES-11, blaGES-35, aph(3')-VI, aac(6')-Ib, sul1, sul2, mph(E), msr(E), armA, strA, strB, cmlA5, arr-2, ant(3'')-II, aadA1-pm, tet(B), tet(39), qacEΔ1, and dfrA7.

The study identified a diverse array of antimicrobial resistance genes in drinking water stored in cisterns from two First Nations communities in Manitoba, Canada. Key findings include the presence of genes such as aac(3')-Ia, aac(6')-Iia, aac(6')-Iic, aph(3')-Ia, acrD, smeB, smeR, FEZ-1, rm3, SPG-1, OXA-21, OXA-119, OXA-205, dfrA14, dfrB6, acrB, acrF, adeF, ceoB, emrA, mexE, mexF, mexI, oprN, oqxB, BRP(MBL), vanSO, axyY, CRP, efrB, macB, mexB, mexC, mexD, mexK, mexQ, mexW, mexY, mtrA, muxB, muxC, oleB, oleC, ompB, oprM, smeD, smeE, golS, mdsB, PER-2, TEM-126, msbA, arnA, bacA, bcrA, MCR-5, rosA, rosB, rpoB2, ugd, mexN, taeA, efpA, rphA, rphB, otr(A), otrC, tetA(48 ), ompH, and triC, which confer resistance to various antibiotics including aminoglycosides, beta-lactams, cephalosporins, carbapenems, fluoroquinolones, macrolides, monobactams, nitroimidazoles, peptides, phenicols, pleuromutilins, rifamycins, tetracyclines, and triclosan.

The study identifies blaPER-1 and blaPER-4 as key genes contributing to high-level ceftazidime-avibactam resistance in Pseudomonas aeruginosa isolates in China.

The study identifies blaPER-1 and blaPER-4 as key genes contributing to high-level ceftazidime-avibactam resistance in Pseudomonas aeruginosa isolates in China.

The study identified various beta-lactamase genes, including blaSPM, blaKPC, blaSHV, blaCTX-M, blaOXA, blaTEM, blaPER, blaVIM, and blaVIM-2 in Pseudomonas aeruginosa, and blaCTX-M, blaTEM, blaKPC, blaNDM, and blaOXA in Klebsiella pneumoniae. Additionally, aac(3)-IV, aadA1, aac(3)-II, sul2, sul1, sul3, dfrA, cmlA, and tetA were found to confer resistance to aminoglycosides, sulfonamides, trimethoprim, chloramphenicol, and tetracyclines.

The study identifies various carbapenemase genes such as bla OXA-48, bla VIM-1, bla NDM-1, bla KPC-3, and bla NDM-5 in carbapenem-resistant E. coli isolates from Spain, highlighting their genetic diversity and geographic distribution.

The study identifies blaPER-3 as a key gene associated with ceftazidime/avibactam resistance in non-carbapenemase-producing Pseudomonas aeruginosa clinical isolates. The loss of blaPER-3 restored susceptibility to CZA and other β-lactams.

The study identified metallo-beta-lactamases (VIM-2, VIM-1, FIM-1), extended-spectrum beta-lactamases (PER-1, GES-1), and other beta-lactamase genes as the primary mechanisms of resistance to ceftazidime-avibactam in Pseudomonas aeruginosa clinical isolates.

Cefepime-taniborbactam showed potent in vitro activity against Enterobacterales and P. aeruginosa, particularly effective against isolates with carbapenemase genes such as blaIMP, blaNDM, and blaVIM, as well as those with mutations in ftsI, ompK35, and ompK36.

The study identified multidrug-resistant Acinetobacter baumannii strains from a neonatal ICU in Egypt, highlighting the presence of various beta-lactamase genes, aminoglycoside resistance genes, macrolide resistance genes, tetracycline resistance genes, and sulfonamide resistance genes.

The study identified multidrug-resistant Acinetobacter baumannii strains from a neonatal ICU in Egypt, highlighting the presence of various beta-lactamase genes, aminoglycoside resistance genes, macrolide resistance genes, tetracycline resistance genes, and sulfonamide resistance genes.

The study identified several carbapenem-resistant Acinetobacter baumannii (CR Ab) isolates from high-touch surfaces in Fijian hospitals, revealing the presence of resistance genes such as bla OXA-23, bla NDM-1, and others, along with mutations in genes like parC and gyrA, contributing to resistance against multiple antibiotics.

The study identified multiple carbapenem-resistant Acinetobacter baumannii isolates carrying various resistance genes, including bla OXA-40, ISAba-1, int-2, bla OXA-23, bla NDM-1, and several ESBL genes. These findings highlight the complex resistance profiles and clonal transmission of CRAB in ICU settings during the COVID-19 pandemic.

The study identified bla NDM, bla KPC, and bla OXA-163 as the main carbapenemase genes in Enterobacterales isolates from Argentina, with NDM and KPC being the most prevalent.

The study identified multiple beta-lactamase genes, including bla NDM-1, bla PER-3, and bla OXA-1, along with other resistance genes such as aac(6′)-Ib-cr6, aph(3″)-Ib, and floR, which contribute to resistance against various antibiotics in Aeromonas isolates.

The study characterizes various carbapenemase genes such as blaIMP-13, blaIMP-94, blaNDM-1, blaNDM-5, blaNDM-7, blaNDM-23, blaVIM-1, blaVIM-2, blaVIM-20, blaKPC-2, blaKPC-3, blaGES-1, blaGES-5, blaGES-7, blaGES-20, blaPER-1, blaVEB-1, blaCTX-M-15, blaCTX-M-9, blaSHV-12, blaFOX-4, blaCMY-2, blaDHA-1, blaOXA-2, blaOXA-10, blaOXA-14, blaOXA-15, and blaOXA-48 in Pseudomonas aeruginosa using MALDI-TOF MS hydrolysis assays.

The study identifies bla KPC-87, bla AFM-2, and bla PER-1 as key genes responsible for ceftazidime/avibactam resistance in carbapenem-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae. Additionally, the GT241A substitution in KPC-87 and the presence of Δ bla TEM-1 contribute to resistance mechanisms.

The study identifies highly drug-resistant Vibrio cholerae isolates harboring the blaPER-7 gene, which confers resistance to extended-spectrum cephalosporins, and the mph(A) gene, which confers resistance to azithromycin. These genes are located on a YemVchMDR1 element, which also contains other resistance genes.

The study identifies several beta-lactamase genes (OXA-396, OXA-101, OXA-494, PAO, PER-1, OXA-50, OXA-488) in clinical P. aeruginosa isolates that confer resistance to beta-lactam antibiotics. The combination of fosfomycin and azithromycin showed synergistic effects, reducing MIC values and disrupting multiple metabolic pathways.