Browse AMR Genes

Explore antimicrobial resistance genes from the literature

blaPSE

beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaPSE

Browse AMR rules for blaPSE

Validation StatusSupported

Overview

Mechanism: integron-borne gene cassette
Validation Method: characterization by isoelectric focusing and enzyme activity
Drug Classes: ampicillin, amoxicillin, ticarcillin, ampicillin/sulbactam, ticarcillin/clavulanic acid, piperacillin, cephalothin, cefoxitin
Organisms: Proteus mirabilis, Vibrio cholerae non-O1, non-O139, Salmonella enterica serovar Typhimurium, Salmonella Typhimurium DT104, Salmonella enterica serovar Agona
Geographic Location: Argentina, Belgium, Czech Republic, France, Italy +1 more
Alleles: 4
Papers: 7
Databases: Reslit

Allele Variants4

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
blaCARB-2	Reslit	1	ampicillin, amoxicillin +1	Proteus mirabilis	France	2000	-	-
blaCARB-7	Reslit	1

Papers7

1

Prevalence of beta-lactamases among 1,072 clinical strains of Proteus mirabilis: a 2-year survey in a French hospital.

PMID 10858357 · 2000

The study identified various beta-lactamase genes including TEM-1, TEM-2, TEM-3, TEM-66, CARB-2, SHV-1, IRT-13, IRT-16, and IRT-2 in Proteus mirabilis strains, highlighting their role in beta-lactam resistance.

Gene Information

Gene Name: blaPSE
Allele: blaCARB-2
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: ampicillinamoxicillinticarcillin
Organisms Tested In: • Proteus mirabilis
Geographic Location: France
Validation Method: characterization by isoelectric focusing and enzyme activity

2

New carbenicillin-hydrolyzing beta-lactamase (CARB-7) from Vibrio cholerae non-O1, non-O139 strains encoded by the VCR region of the V. cholerae genome.

PMID 12069969 · 2002

The study identifies a new beta-lactamase, CARB-7, from Vibrio cholerae non-O1, non-O139 strains, which hydrolyzes carbenicillin and other beta-lactam antibiotics.

Gene Information

Gene Name: blaPSE
Allele: blaCARB-7
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: ampicillinticarcillin
Organisms Tested In: • Vibrio cholerae non-O1, non-O139
Geographic Location: Argentina
Validation Method: nucleotide sequencing and enzyme activity assays
Sequence Accession: AF409092

3

Antibiotic Resistance Genes and Salmonella Genomic Island 1 in Salmonella enterica Serovar Typhimurium Isolated in Italy.

PMID 12183234 · 2002

The study identifies antibiotic resistance genes and the presence of Salmonella Genomic Island 1 (SGI1) in multidrug-resistant Salmonella enterica serovar Typhimurium isolates from Italy. Key resistance genes include aadA2, pse-1, floR, tetA, and tetR, which contribute to resistance against various antibiotics.

Gene Information

Gene Name: blaPSE
Allele: blaPSE-1
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: integron-borne gene cassette
Confers Resistance To: ampicillin
Organisms Tested In: • Salmonella enterica serovar Typhimurium
Geographic Location: Italy
Validation Method: PCR amplification and sequencing
Sequence Accession: AF261825

4

Characterization of integron mediated antimicrobial resistance in Salmonella isolated from diseased swine.

PMID 12528827 · 2003

The study identified two integrons in Salmonella Typhimurium DT104 strains, one containing aadA2 which confers resistance to streptomycin and another containing blaPSE-1 which confers resistance to ampicillin. Non-DT104 strains showed varying levels of resistance but lacked the specific integron patterns seen in DT104.

Gene Information

Gene Name: blaPSE
Allele: blaPSE-1
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: confers resistance to ampicillin
Confers Resistance To: ampicillin
Organisms Tested In: • Salmonella Typhimurium DT104
Geographic Location: United States
Validation Method: DNA sequencing

5

Evolution of antibiotic resistance in Salmonella enterica serovar typhimurium strains isolated in the Czech Republic between 1984 and 2002.

PMID 12760885 · 2003

The study identifies the aadA21 gene, a novel variant of the aadA gene, and other resistance genes such as blaPSE-1, floR, sul1, and tetG in Salmonella enterica serovar Typhimurium strains from the Czech Republic between 1984 and 2002.

Gene Information

Gene Name: blaPSE
Allele: blaPSE-1
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: ampicillin
Organisms Tested In: • Salmonella enterica serovar Typhimurium
Geographic Location: Czech Republic
Validation Method: PCR and DNA sequencing
Sequence Accession: AY171244

6

Salmonella genomic island 1 multidrug resistance gene clusters in Salmonella enterica serovar Agona isolated in Belgium in 1992 to 2002.

PMID 15215102 · 2004

The study identifies various multidrug resistance gene clusters in Salmonella enterica serovar Agona, including SGI1-A, SGI1-G, and several deletion variants. Key genes include floR, aadA2, pse-1, dfrA10, and orf513, which confer resistance to multiple antibiotics.

Gene Information

Gene Name: blaPSE
Allele: blaPSE-1
Encodes: beta-lactam resistance gene
Source Database: Reslit
Confers Resistance To: ampicillin
Organisms Tested In: • Salmonella enterica serovar Agona
Geographic Location: Belgium
Validation Method: PCR and sequencing
Sequence Accession: AY434091|AY434092|AY434093

7

CARB-9, a Carbenicillinase Encoded in the VCR Region of Vibrio cholerae Non-O1, Non-O139 Belongs to a Family of Cassette-Encoded beta-lactamases.

PMID 15388476 · 2004

The study identifies blaCARB-9 as a novel carbenicillinase encoded in the VCR region of Vibrio cholerae non-O1, non-O139, which belongs to a family of cassette-encoded beta-lactamases.

Gene Information

Gene Name: blaPSE
Allele: blaCARB-9
Encodes: beta-lactamase
Source Database: Reslit
Confers Resistance To: ampicillinampicillin/sulbactamticarcillinticarcillin/clavulanic acidpiperacillincephalothincefoxitin
Organisms Tested In: • Vibrio cholerae non-O1, non-O139
Validation Method: sequencing and biochemical analysis
Sequence Accession: AY248038