Browse AMR Genes

Explore antimicrobial resistance genes from the literature

blaPenI

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaPenI

Browse AMR rules for blaPenI

Overview

Drug Classes: Ceftazidime
Organisms: Burkholderia pseudomallei, Escherichia coli
Papers: 1
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
P167S	-	-	Burkholderia pseudomallei, Escherichia coli	Ceftazidime	Reslit	Candidate
C69Y	-	-	Escherichia coli, Burkholderia pseudomallei	Ceftazidime	Reslit	Candidate

Papers1

1

Burkholderia pseudomallei PenI β-lactamase and variants are potently inhibited by taniborbactam.

PMID 40938351 · 2025

Mutations C69Y and P167S confer increased resistance to ceftazidime.

Mutation Information

blaPenI: p.P167S blaPenI: p.C69Y

Protein Change: P167S, C69Y
Organisms: Burkholderia pseudomallei, Escherichia coli
Confers Resistance To: Ceftazidime
Source Database: Reslit