Browse AMR Genes

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blaRAD

class D beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaRAD

Browse AMR rules for blaRAD

Validation StatusConfirmed2+ DBs

Overview

Mechanism: hydrolysis of β-lactam antibiotics
Validation Method: expression in E. coli BL21 (DE3) and MIC testing
Drug Classes: Carbapenem, Penicillin, Cephalosporin, Aztreonam, CARBAPENEM, Beta-lactams
Organisms: Riemerella anatipestifer SCVM0004, Escherichia coli BL21 (DE3), Riemerella anatipestifer
Geographic Location: China
Alleles: 3
Papers: 2
Databases: Card DatabaseReference Gene CatalogReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
bla_RAD-1	Reslit	1	Carbapenem, Penicillin +2	Riemerella anatipestifer SCVM0004 +1	China	2023	CP104076\|UWS41116	-
blaRAD-1

Papers2

1

Identification of a novel carbapenem-hydrolysing class D beta-lactamase RAD-1 in Riemerella anatipestifer.

PMID 36883515 · 2023

A novel chromosomally located class D carbapenemase RAD-1 was identified in R. anatipestifer SCVM0004, which confers resistance to various β-lactam antibiotics including carbapenems, penicillins, cephalosporins, and monobactams.

Gene Information

Gene Name: blaRAD
Allele: bla_RAD-1
Encodes: class D beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of β-lactam antibiotics
Confers Resistance To: CarbapenemPenicillinCephalosporinAztreonam
Organisms Tested In: • Riemerella anatipestifer SCVM0004
• Escherichia coli BL21 (DE3)
Geographic Location: China
Validation Method: expression in E. coli BL21 (DE3) and MIC testing
Sequence Accession: CP104076|UWS41116

2

Identification of a novel carbapenem-hydrolysing class D β-lactamase RAD-1 in Riemerella anatipestifer.

PMID 36883515 · 2023

Gene Information

Gene Name: blaRAD
Allele: blaRAD-1
Encodes: carbapenem-hydrolyzing class D beta-lactamase RAD-1
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Riemerella anatipestifer
Sequence Accession: CP104076.1
Protein Accession: UWS41116.1
Notes: ARO:3007483

3

Identification of a novel carbapenem-hydrolysing class D β-lactamase RAD-1 in Riemerella anatipestifer.

PMID 36883515 · 2023

Gene Information

Gene Name: blaRAD
Allele: blaRAD-1
Encodes: carbapenem-hydrolyzing class D beta-lactamase RAD-1, RAD beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Riemerella anatipestifer
Sequence Accession: CP104076.1
Protein Accession: UWS41116.1
Notes: ARO:3007483

4

Unveiling the silent threat: A comprehensive review of Riemerella anatipestifer - From pathogenesis to drug resistance.

PMID 40020410 · 2025

This review highlights the pathogenesis, virulence factors, and antibiotic resistance genes of Riemerella anatipestifer, emphasizing its significance in poultry farming and the need for further research on its resistance mechanisms.

Gene Information

Gene Name: blaRAD
Allele: blaRAD
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: hydrolyzes beta-lactam antibiotics, rendering them inactive
Confers Resistance To: Beta-lactams
Organisms Tested In: • Riemerella anatipestifer
Geographic Location: China
Validation Method: experimental validation