Browse AMR Genes

Explore antimicrobial resistance genes from the literature

blaRAHN

extended-spectrum class A beta-lactamase RAHN-1

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaRAHN

Browse AMR rules for blaRAHN

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic inactivation
Validation Method: cloning in E. coli DH10B and susceptibility testing
Drug Classes: AMOXICILLIN, PIPERACILLIN, AMPICILLIN, CEPHALOSPORIN, Cefoxitin, Cephalothin, Ceftriaxone, Cefotaxime, Piperacillin, Ticarcillin, Ceftazidime
Organisms: Rahnella aquatilis, E. coli DH10B, Rahnella sp. 42-Carrot, Rahnella sp. 9-Pear, Rahnella aquatilis
Geographic Location: Norway, United States
Alleles: 7
Papers: 6
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants7

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
blaRAHN-1	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	5	AMOXICILLIN, PIPERACILLIN +8	Rahnella aquatilis +2

Papers6

1

Biochemical-genetic characterization of the chromosomally encoded extended-spectrum class A beta-lactamase from Rahnella aquatilis.

PMID 11557504 · 2001

Gene Information

Gene Name: blaRAHN
Allele: blaRAHN-1
Encodes: extended-spectrum class A beta-lactamase RAHN-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINPIPERACILLINAMPICILLINCEPHALOSPORIN
Organisms Tested In: • Rahnella aquatilis
Sequence Accession: AF338038.1
Protein Accession: AAK83220.1
Notes: Chromosomal

2

Biochemical-genetic characterization of the chromosomally encoded extended-spectrum class A beta-lactamase from Rahnella aquatilis.

PMID 11557504 · 2001

The study identifies a novel chromosomally encoded extended-spectrum class A beta-lactamase, RAHN-1, from Rahnella aquatilis, which confers resistance to various beta-lactam antibiotics including cefoxitin, cephalothin, cefuroxime, cefepime, ceftriaxone, cefotaxime, piperacillin, and ticarcillin.

Gene Information

Gene Name: blaRAHN
Allele: blaRAHN-1
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis
Confers Resistance To: CefoxitinCephalothinCeftriaxoneCefotaximePiperacillinTicarcillin
Organisms Tested In: • Rahnella aquatilis
• E. coli DH10B
Validation Method: cloning in E. coli DH10B and susceptibility testing
Sequence Accession: AF338038

3

Biochemical-genetic characterization of the chromosomally encoded extended-spectrum class A beta-lactamase from Rahnella aquatilis.

PMID 11557504 · 2001

Gene Information

Gene Name: blaRAHN
Allele: blaRAHN-1
Encodes: extended-spectrum class A beta-lactamase RAHN-1
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINPIPERACILLINAMPICILLINCEPHALOSPORIN
Organisms Tested In: • Rahnella aquatilis
Sequence Accession: AF338038.1
Protein Accession: AAK83220.1
Notes: Chromosomal

4

RAHN-2, a chromosomal extended-spectrum class A beta-lactamase from Rahnella aquatilis.

PMID 20511369 · 2010

Gene Information

Gene Name: blaRAHN
Allele: blaRAHN-2
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Rahnella sp. 42-Carrot
Sequence Accession: HM114350
Notes: Chromosomal

5

RAHN-2, a chromosomal extended-spectrum class A beta-lactamase from Rahnella aquatilis.

PMID 20511369 · 2010

Gene Information

Gene Name: blaRAHN
Allele: blaRAHN-2
Encodes: extended-spectrum class A beta-lactamase RAHN-2
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINPIPERACILLINAMPICILLINCEPHALOSPORIN
Organisms Tested In: • Rahnella sp. 42-Carrot
Sequence Accession: HM114350.1
Protein Accession: ADO51656.1
Notes: Chromosomal

6

RAHN-2, a chromosomal extended-spectrum class A beta-lactamase from Rahnella aquatilis.

PMID 20511369 · 2010

Gene Information

Gene Name: blaRAHN
Allele: blaRAHN-2
Encodes: extended-spectrum class A beta-lactamase RAHN-2
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINPIPERACILLINAMPICILLINCEPHALOSPORIN
Organisms Tested In: • Rahnella sp. 42-Carrot
Sequence Accession: HM114350.1
Protein Accession: ADO51656.1
Notes: Chromosomal

7

RAHN-2, a chromosomal extended-spectrum class A beta-lactamase from Rahnella aquatilis.

PMID 20511369 · 2010

Gene Information

Gene Name: blaRAHN
Allele: blaRAHN-2
Encodes: extended-spectrum class A beta-lactamase RAHN-2
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINPIPERACILLINAMPICILLINCEPHALOSPORIN
Organisms Tested In: • Rahnella sp. 42-Carrot
Sequence Accession: HM114350.1
Protein Accession: ADO51656.1
Notes: Chromosomal

8

Extended-spectrum Beta-lactamase gene sequences in gram-negative saprophytes on retail organic and nonorganic spinach.

PMID 21216903 · 2011

The study identified extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15 and bla RAHN-2, in gram-negative saprophytes isolated from retail spinach, indicating that fresh produce can serve as a reservoir for drug resistance genes.

Gene Information

Gene Name: blaRAHN
Allele: blaRAHN-2
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis
Confers Resistance To: CeftazidimeCefotaxime
Organisms Tested In: • Rahnella aquatilis
Geographic Location: United States
Validation Method: PCR and sequencing
Sequence Accession: HQ339919|HQ339920|HQ339921|HQ339922|HQ339923|HQ339924

9

Extended-spectrum beta-lactamase-producing bacteria are not detected in supragingival plaque samples from human fecal carriers of ESBL-producing Enterobacteriaceae.

PMID 25206941 · 2014

The study identified a single instance of Rahnella aquatilis carrying the class A ESBL gene bla RAHN-1/2 in an oral sample, but no other ESBL-producing bacteria or genes were detected in supragingival plaque samples from fecal carriers of CTX-M-producing E. coli.

Gene Information

Gene Name: blaRAHN
Allele: blaRAHN-1/2
Encodes: class A extended-spectrum beta-lactamase
Source Database: Reslit
Organisms Tested In: • Rahnella aquatilis
Geographic Location: Norway
Validation Method: PCR and sequencing
Sequence Accession: CP003512

10

Evaluation of a Lateral Flow Immunoassay for Rapid Detection of CTX-M Producers from Blood Cultures.

PMID 36677420 · 2023

Gene Information

Gene Name: blaRAHN
Allele: blaRAHN-4
Encodes: extended-spectrum class A beta-lactamase RAHN-4
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Rahnella aquatilis
Sequence Accession: ON698183.1
Protein Accession: USK11984.1
Notes: ARO:3009037

11

Evaluation of a Lateral Flow Immunoassay for Rapid Detection of CTX-M Producers from Blood Cultures.

PMID 36677420 · 2023

Gene Information

Gene Name: blaRAHN
Allele: blaRAHN-3
Encodes: extended-spectrum class A beta-lactamase RAHN-3
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Rahnella aquatilis
Sequence Accession: ON698182.1
Protein Accession: USK11983.1
Notes: ARO:3009036

12

Evaluation of a Lateral Flow Immunoassay for Rapid Detection of CTX-M Producers from Blood Cultures.

PMID 36677420 · 2023

Gene Information

Gene Name: blaRAHN
Allele: blaRAHN-3
Encodes: extended-spectrum class A beta-lactamase RAHN-3, RAHN beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Rahnella aquatilis
Sequence Accession: ON698182.1
Protein Accession: USK11983.1
Notes: ARO:3009036

13

Evaluation of a Lateral Flow Immunoassay for Rapid Detection of CTX-M Producers from Blood Cultures.

PMID 36677420 · 2023

Gene Information

Gene Name: blaRAHN
Allele: blaRAHN-4
Encodes: extended-spectrum class A beta-lactamase RAHN-4, RAHN beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Rahnella aquatilis
Sequence Accession: ON698183.1
Protein Accession: USK11984.1
Notes: ARO:3009037

14

Evaluation of a Lateral Flow Immunoassay for Rapid Detection of CTX-M Producers from Blood Cultures.

PMID 36677420 · 2023

Gene Information

Gene Name: blaRAHN
Allele: blaRAHN-5
Encodes: extended-spectrum class A beta-lactamase RAHN-5
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Rahnella aquatilis
Sequence Accession: ON698184.1
Protein Accession: USK11985.1
Notes: ARO:3009038

15

Evaluation of a Lateral Flow Immunoassay for Rapid Detection of CTX-M Producers from Blood Cultures.

PMID 36677420 · 2023

Gene Information

Gene Name: blaRAHN
Allele: blaRAHN-5
Encodes: extended-spectrum class A beta-lactamase RAHN-5, RAHN beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Rahnella aquatilis
Sequence Accession: ON698184.1
Protein Accession: USK11985.1
Notes: ARO:3009038

16

Evaluation of a Lateral Flow Immunoassay for Rapid Detection of CTX-M Producers from Blood Cultures.

PMID 36677420 · 2023

Gene Information

Gene Name: blaRAHN
Allele: blaRAHN-6
Encodes: extended-spectrum class A beta-lactamase RAHN-6
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Rahnella aquatilis
Sequence Accession: ON698185.1
Protein Accession: USK11986.1
Notes: ARO:3009039

17

Evaluation of a Lateral Flow Immunoassay for Rapid Detection of CTX-M Producers from Blood Cultures.

PMID 36677420 · 2023

Gene Information

Gene Name: blaRAHN
Allele: blaRAHN-6
Encodes: extended-spectrum class A beta-lactamase RAHN-6, RAHN beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CEPHALOSPORIN
Organisms Tested In: • Rahnella aquatilis
Sequence Accession: ON698185.1
Protein Accession: USK11986.1
Notes: ARO:3009039

18

Biochemical-genetic characterization of the chromosomally encoded extended-spectrum class A beta-lactamase from Rahnella aquatilis.

PMID unpublished, 11557504 · 2001

Gene Information

Gene Name: blaRAHN
Allele: blaRAHN-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINAMPICILLINPIPERACILLIN
Organisms Tested In: • Rahnella sp. 9-Pear, Rahnella aquatilis
Sequence Accession: GU645205, AF338038
Notes: Chromosomal

19

Gene Information

Gene Name: blaRAHN
Allele: blaRAHN-1
Encodes: RAHN beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Rahnella aquatilis
Sequence Accession: NG_049975.1
Protein Accession: WP_063864600.1
Notes: ARO:3006979

20

Gene Information

Gene Name: blaRAHN
Allele: blaRAHN-2
Encodes: RAHN beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Rahnella sp. 42-Carrot
Sequence Accession: NG_049976.1
Protein Accession: WP_063864601.1
Notes: ARO:3006980