Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
class A beta-lactamase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaSCO-1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 12 | Penicillin, TICARCILLIN +19 |
| Escherichia coli +5 |
| Argentina, Europe, Cameroon, Malawi, Italy, Ethiopia, Ghana |
| 2007, 2018, 2019, 2020, 2024, 2025 |
| EF104648 |
| ABL75133.1 |
| bla(SCO-1) | Reslit | 1 | Carbapenem | Klebsiella pneumoniae | - | 2022 | - | - |
| bla_SCO-1 | Reslit | 1 | Carbapenem, Cephalosporin | Klebsiella pneumoniae | Ghana | 2023 | - | - |
| blaSCO-2 | Reference Gene Catalog | 1 | BETA-LACTAM | Escherichia coli | - | 2025 | JBLGDR010000062.1 | MFS8239293.1 |
SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli.
The study identifies SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli, which hydrolyzes penicillins and shows resistance to clavulanic acid and tazobactam.
Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina.
The study identifies a novel narrow-spectrum beta-lactamase, SCO-1, in Acinetobacter spp. from Argentina, which hydrolyzes penicillins and is inhibited by clavulanic acid.
Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina.
Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina.
Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina.
Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina.
In vivo selection of a multidrug-resistant Aeromonas salmonicida during medicinal leech therapy.
The study identifies 13 antibiotic resistance genes in a multidrug-resistant Aeromonas salmonicida strain, including the ESBL CTX-M-3, TEM-1, and the unusual β-lactamase SCO-1, along with other resistance mechanisms such as aminoglycoside modification, sulfonamide resistance, tetracycline efflux, and chloramphenicol acetylation.
Genome Sequencing of Extended-Spectrum β-Lactamase (ESBL)-Producing Klebsiella pneumoniae Isolated from Pigs and Abattoir Workers in Cameroon.
The study identified multiple antibiotic resistance genes in ESBL-producing K. pneumoniae isolates from pigs and abattoir workers in Cameroon, including bla CTX-M-15, bla TEM-1B, bla SHV-28, and others, highlighting the presence of multidrug-resistant strains and their potential for zoonotic transmission.
Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages.
The study identified multiple ESBL genes, including bla CTX-M-15, several bla SHV, bla TEM-63, and bla OXA-10, along with other AMR genes across diverse lineages of K. pneumoniae isolates from Malawi. No carbapenem resistance genes were detected, but plasmids similar to carbapenem resistance-associated plasmid pNDM-mar were found.
Reduced Susceptibility to Carbapenems in a Klebsiella pneumoniae Clinical Isolate Producing SCO-1 and CTX-M-15 β-Lactamases Together with OmpK35 and OmpK36 Porin Deficiency.
The study identifies a carbapenem-resistant Klebsiella pneumoniae isolate producing blaSCO-1 and blaCTX-M-15 beta-lactamases along with deficiencies in OmpK35 and OmpK36 porins, highlighting the complexity of carbapenem resistance mechanisms.
First Belgian Report of Ertapenem Resistance in an ST11 Klebsiella Pneumoniae Strain Isolated from a Dog Carrying bla(SCO-1) and bla(DHA-1) Combined with Permeability Defects.
Whole genome analysis of Pantoea species identified from sepsis patients in selected Ethiopian referral hospitals: emerging pathogens.
The study identified multiple Pantoea species, including P. dispersa, P. septica, and a novel Pantoea species, carrying various antimicrobial resistance genes such as blaCTX-M-15, blaSCO-1, blaTEM-1D, aac(3)-IIa, and blaCTX-M-9. These genes conferred resistance to multiple antibiotics, highlighting the emergence of multidrug-resistant Pantoea isolates in Ethiopian referral hospitals.
Antimicrobial Resistance in Wastewater Samples from Kumasi, Ghana: A Genomic and Metagenomic Analysis
The study identified several AMR genes and mutations in P. aeruginosa and K. pneumoniae isolates from wastewater samples in Kumasi, Ghana, highlighting the presence of multidrug-resistant strains carrying genes such as blaCTX-M-15, blaOXA-488, and qnrVC1, along with mutations in gyrA and parC contributing to fluoroquinolone resistance.
Shelter dogs as reservoirs of international clones of Escherichia coli carrying mcr-1.1 and bla(CTX-M) resistance genes in Lima, Peru.
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL-producing Klebsiella pneumoniae in a Ghanaian teaching hospital.
The study identified multiple beta-lactamase genes, including bla SHV, bla CTX-M-15, bla TEM-1B, and bla OXA-1, as well as a variety of other resistance genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3'')-Ib, aph(6)-Id, aadA1, qnrB1, qnrB4, qnrB2, qnrB19, sul2, sul1, dfrA14, dfrA15, OqxA, OqxB, fosA, qacE, tetA, and tetD. Mutations in ompK36 and ompK37 were also found to contribute to reduced susceptibility to cephalosporins and carbapenems.
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