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blaSFC

class A beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaSFC

Browse AMR rules for blaSFC

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic inactivation
Validation Method: plasmid transformation and MIC testing
Drug Classes: Ampicillin, Amoxicillin, Piperacillin, Cephalothin, Aztreonam, Meropenem, Imipenem, MEROPENEM, ERTAPENEM, AMOXICILLIN, CEFOXITIN, IMIPENEM, CEFIXIME, CEFEPIME, AMPICILLIN+CLAVULANIC ACID, AMPICILLIN, CARBAPENEM, CEFOTAXIME, CEFTAZIDIME, AMOXICILLIN+CLAVULANIC ACID, PIPERACILLIN+TAZOBACTAM, PIPERACILLIN, Carbapenem, Penicillin, Cephalosporin
Organisms: Serratia fonticola UTAD54, Escherichia coli, Serratia fonticola, Stenotrophomonas maltophilia, Serratia sp. JSRIV001, Serratia fonticola AU-AP2C
Geographic Location: USA|Global
Alleles: 4
Papers: 4
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants4

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
blaSFC-I	Reslit	1	Ampicillin, Amoxicillin +5	Serratia fonticola UTAD54 +1	-	2004	AY354402	-
blaSFC-1

Papers4

1

Molecular characterization of a carbapenem-hydrolyzing class A beta-lactamase, SFC-1, from Serratia fonticola UTAD54.

PMID 15155245 · 2004

The study identifies SFC-1, a novel class A beta-lactamase from Serratia fonticola UTAD54, which confers resistance to various beta-lactam antibiotics including carbapenems.

Gene Information

Gene Name: blaSFC
Allele: blaSFC-I
Encodes: class A beta-lactamase
Source Database: Reslit
Confers Resistance To: AmpicillinAmoxicillinPiperacillinCephalothinAztreonamMeropenemImipenem
Organisms Tested In: • Serratia fonticola UTAD54
• Escherichia coli
Validation Method: plasmid transformation and MIC testing
Sequence Accession: AY354402

2

Molecular characterization of a carbapenem-hydrolyzing class A beta-lactamase, SFC-1, from Serratia fonticola UTAD54.

PMID 15155245 · 2004

Gene Information

Gene Name: blaSFC
Allele: blaSFC-1
Encodes: carbapenem-hydrolyzing class A beta-lactamase SFC-1
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Serratia fonticola
Sequence Accession: AY354402.1
Protein Accession: AAR06587.1
Notes: Chromosomal class A beta-lactamase

3

Molecular characterization of a carbapenem-hydrolyzing class A beta-lactamase, SFC-1, from Serratia fonticola UTAD54.

PMID 15155245 · 2004

Gene Information

Gene Name: blaSFC
Allele: blaSFC-1
Encodes: carbapenem-hydrolyzing class A beta-lactamase SFC-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Serratia fonticola
Sequence Accession: AY354402.1
Protein Accession: AAR06587.1
Notes: Chromosomal class A beta-lactamase

4

Molecular characterization of a carbapenem-hydrolyzing class A beta-lactamase, SFC-1, from Serratia fonticola UTAD54.

PMID 15155245 · 2004

Gene Information

Gene Name: blaSFC
Allele: blaSFC-1
Encodes: carbapenem-hydrolyzing class A beta-lactamase SFC-1
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Serratia fonticola
Sequence Accession: AY354402.1
Protein Accession: AAR06587.1
Notes: Chromosomal class A beta-lactamase

5

Molecular characterization of a carbapenem-hydrolyzing class A beta-lactamase, SFC-1, from Serratia fonticola UTAD54.

PMID 15155245 · 2004

Gene Information

Gene Name: blaSFC
Allele: blaSFC-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Serratia fonticola
Sequence Accession: AY354402
Notes: Chromosomal class A beta-lactamase

6

Class A Carbapenemases: Mechanisms of Action and Resistance

The paper characterizes various class A carbapenemases, including KPC, GES, SME, NmcA, FRI-1, BIC-1, SFC-1, and PenA, highlighting their roles in conferring resistance to carbapenems and other β-lactam antibiotics.

Gene Information

Gene Name: blaSFC
Allele: blaSFC-1
Encodes: serine beta-lactamase
Source Database: Reslit
Confers Resistance To: CarbapenemPenicillinCephalosporin
Organisms Tested In: • Stenotrophomonas maltophilia
Geographic Location: USA|Global
Validation Method: experimental validation through cloning and MIC testing
Sequence Accession: PDB:3E2K|PDB:3E2L|PDB:3RXW|PDB:3RXX|PDB:3NI9|PDB:3NIA|PDB:4QU3|PDB:4GNU|PDB:4H8R|PDB:3V3S|PDB:4EQI|PDB:4EUZ|PDB:4EV4|PDB:1BUE|PDB:1BUL|PDB:1DY6|PDB:3W4Q

7

Emergence of rare carbapenemases (FRI, GES-5, IMI, SFC and SFH-1) in Enterobacterales isolated from surface waters in Japan.

PMID 35137119 · 2022

Gene Information

Gene Name: blaSFC
Allele: blaSFC-2
Encodes: carbapenem-hydrolyzing class A beta-lactamase SFC-2
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Serratia sp. JSRIV001
Sequence Accession: CP074147.1
Protein Accession: UAN48719.1
Notes: ARO:3009045

8

Emergence of rare carbapenemases (FRI, GES-5, IMI, SFC and SFH-1) in Enterobacterales isolated from surface waters in Japan.

PMID 35137119 · 2022

Gene Information

Gene Name: blaSFC
Allele: blaSFC-2
Encodes: carbapenem-hydrolyzing class A beta-lactamase SFC-2, SFC beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Serratia sp. JSRIV001
Sequence Accession: CP074147.1
Protein Accession: UAN48719.1
Notes: ARO:3009045

9

QM/MM Simulations Reveal the Determinants of Carbapenemase Activity in Class A beta-lactamases.

PMID 35877936 · 2022

The study identifies key structural and dynamic factors influencing carbapenemase activity in class A beta-lactamases through QM/MM simulations, highlighting the roles of the 6α-1R-hydroxyethyl group, Asn132, and the disulfide bridge in determining carbapenem hydrolysis efficiency.

Gene Information

Gene Name: blaSFC
Allele: blaSFC-1
Encodes: class A beta-lactamase
Source Database: Reslit
Confers Resistance To: Carbapenem
Organisms Tested In: • Escherichia coli
Validation Method: QM/MM simulations

10

Gene Information

Gene Name: blaSFC
Allele: blaSFC-1
Encodes: SFC beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Serratia fonticola
Sequence Accession: NG_049980.1
Protein Accession: WP_024531321.1
Notes: ARO:3006985

11

Gene Information

Gene Name: blaSFC
Allele: blaSFC-3
Encodes: carbapenem-hydrolyzing class A beta-lactamase SFC-3
Source Database: Reference Gene Catalog
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Serratia fonticola AU-AP2C
Sequence Accession: ASZA01000006.1