Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| D104R | - | - | Escherichia coli | cefotaxime|ceftazidime | Reslit | Candidate |
| G238A | - | conferred the most resistance to penicillins and cephalosporins | Escherichia coli | penicillins|cephalosporins | Reslit | Candidate |
| G238S | - | conferred resistance to penicillins and cephalosporins | Escherichia coli | penicillins|cephalosporins |
Reslit |
| Candidate |
| G238P | - | demonstrated lower levels of resistance | Escherichia coli | penicillins|cephalosporins | Reslit | Candidate |
| G238C | - | demonstrated lower levels of resistance | Escherichia coli | penicillins|cephalosporins | Reslit | Candidate |
| G238Q | - | demonstrated lower levels of resistance | Escherichia coli | penicillins|cephalosporins | Reslit | Candidate |
| G238D | - | demonstrated lower levels of resistance | Escherichia coli | penicillins|cephalosporins | Reslit | Candidate |
| D104K | - | - | Escherichia coli | cefotaxime|ceftazidime | Reslit | Candidate |
| - | - | Klebsiella pneumoniae | ceftazidime|piperacillin-tazobactam | Reslit | Candidate |
Role of Asp104 in the SHV beta-lactamase.
Mutations at Ambler position 104 and 238 contribute to resistance
Amino acid substitutions at Ambler position Gly238 in the SHV-1 beta-lactamase: exploring sequence requirements for resistance to penicillins and cephalosporins.
Mutations at Ambler position Gly238 in SHV-1 beta-lactamase confer resistance to penicillins and cephalosporins.
High-level expression of chromosomally encoded SHV-1 beta-lactamase and an outer membrane protein change confer resistance to ceftazidime and piperacillin-tazobactam in a clinical isolate of Klebsiella pneumoniae.
The A→C change in the second position of the −10 region of the blaSHV-1 promoter leads to reduced β-lactamase expression and lower resistance.
© 2026 ResLit. Data sourced from PubMed literature analysis.
Built for antimicrobial resistance research