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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
subclass B1 metallo-beta-lactamase SIM-1
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaSIM-1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 20 | MEROPENEM, ERTAPENEM +21 |
| China, Global|India|Spain, South Korea, United States, Sudan, various countries|Global, Bangladesh, Asia/South Pacific|Europe|Latin America|Middle East/Africa|North America, Asia|Africa|America|Europe |
| 2005, 2011, 2012, 2014, 2019, 2021, 2022, 2023, 2024, 2025 |
| AY887066.1 |
| AAX76774.1 |
| bla(SIM-1) | Reslit | 1 | Imipenem, Meropenem +3 | Acinetobacter baumannii +1 | Korea | 2005 | AY887066 | - |
| blaSIM | Reslit | 11 | Carbapenem, Cephalosporin +5 | Acinetobacter baumannii +15 | Global|India|Spain, Germany, Middle East|Afghanistan|Iraq|Egypt|Pakistan|Lebanon|Iran|Jordan|Persian Gulf Countries|United Arab Emirates|Kuwait|Qatar|Bahrain|Oman|Saudi Arabia|Turkey, East India, China, Iraq, Shanxi Province, China, China|global, India | 2012, 2013, 2015, 2019, 2020, 2022, 2023 | NCBI BioProject: PRJNA632023 | - |
| blaSIM-2 | Card DatabaseReference Gene Catalog | 3 | CARBAPENEM | Pseudomonas aeruginosa | - | 2021 | KT013203.1 | ALA09092.1 |
| bla_SIM | Reslit | 1 | Imipenem, Meropenem +2 | Pseudomonas aeruginosa | Iran | 2024 | - | - |
Novel acquired metallo-beta-lactamase gene, bla(SIM-1), in a class 1 integron from Acinetobacter baumannii clinical isolates from Korea.
Novel acquired metallo-beta-lactamase gene, bla(SIM-1), in a class 1 integron from Acinetobacter baumannii clinical isolates from Korea.
Novel acquired metallo-beta-lactamase gene, bla(SIM-1), in a class 1 integron from Acinetobacter baumannii clinical isolates from Korea.
The study identifies a novel metallo-beta-lactamase gene, bla(SIM-1), in Acinetobacter baumannii clinical isolates from Korea, which confers resistance to multiple beta-lactam antibiotics including carbapenems.
Novel acquired metallo-beta-lactamase gene, bla(SIM-1), in a class 1 integron from Acinetobacter baumannii clinical isolates from Korea.
Clinical carbapenem-resistant Acinetobacter baylyi strain coharboring blaSIM-1 and blaOXA-23 from China.
The study reports the first detection of blaSIM-1 in China in a carbapenem-resistant Acinetobacter baylyi strain, along with blaOXA-23, both located on a large plasmid.
Clinical carbapenem-resistant Acinetobacter baylyi strain coharboring blaSIM-1 and blaOXA-23 from China.
The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace.
The paper discusses various virulence factors and mechanisms contributing to the pathogenicity and antibiotic resistance of Acinetobacter baumannii, including biofilm formation, surface polysaccharides, and outer membrane proteins.
The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace.
The paper discusses various virulence factors and mechanisms contributing to the pathogenicity and antibiotic resistance of Acinetobacter baumannii, including biofilm formation, surface polysaccharides, and outer membrane proteins.
DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates.
The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.
CarbAcineto NP test for rapid detection of carbapenemase-producing Acinetobacter spp.
The study introduces the CarbAcineto NP test, a modified version of the Carba NP test, for the rapid and accurate detection of carbapenemase-producing Acinetobacter spp. The test successfully identifies various carbapenemases including OXA-23, OXA-24/OXA-40, OXA-58, OXA-143, GES-11, GES-14, NDM-1, NDM-2, IMP-1, IMP-4, VIM-4, and SIM-1.
Dissemination of carbapenemases producing Gram negative bacteria in the Middle East.
The study reviews the dissemination of carbapenemase-producing Gram-negative bacteria in the Middle East, highlighting the prevalence of KPC, VIM, IMP, NDM, and OXA-48 enzymes in various bacterial species such as Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa.
Phenotypic and Genotypic Characterization of Acinetobacter spp. Panel Strains: A Cornerstone to Facilitate Antimicrobial Development.
The study characterized various AMR genes in Acinetobacter spp. including blaPER-1, blaTEM-1D, blaADC-31, blaOXA-82, aac(3')-Ia, aac(6')-Il, aph(3')-Ic, strAB, and others. Mutations in gyrA and parC were associated with fluoroquinolone resistance. Overexpression of efflux pumps like adeB and adeJ contributed to multidrug resistance.
The first report of a novel IncHI1B bla (SIM-1)-carrying megaplasmid pSIM-1-BJ01 from a clinical Klebsiella pneumoniae isolate.
The study reports the first sequence of a transferable blaSIM-1-carrying plasmid, pSIM-1-BJ01, from a clinical Klebsiella pneumoniae isolate, highlighting its role in carbapenem resistance.
Detection of carbapenemase-producing Pseudomonas aeruginosa by phenotypic and genotypic methods in a tertiary care hospital of East India.
The study detected carbapenemase-producing Pseudomonas aeruginosa isolates, with bla VIM, bla NDM-1, bla SIM, and bla GIM being the most prevalent genes. Co-production of multiple carbapenemase genes was also observed.
High Expression of Metallo-beta-lactamase Contributed to the Resistance to Carbapenem in Clinical Isolates of Pseudomonas aeruginosa from Baotou, China.
The study identified blaSIM, blaIMP, and blaVIM as metallo-beta-lactamase genes contributing to carbapenem resistance in Pseudomonas aeruginosa. Additionally, mutations in oprD2 and overexpression of mexA were also linked to resistance.
Prevalence of metallo-β-lactamase-producing Pseudomonas aeruginosa isolated from diabetic foot infections in Iraq.
The study identified bla VIM, bla IMP, bla SPM, bla SIM, and bla NDM genes in MBL-producing P. aeruginosa isolates from diabetic foot infections in Iraq.
Emergence of NDM-5-Producing Carbapenem-Resistant Klebsiella pneumoniae and SIM-Producing Hypervirulent Klebsiella pneumoniae Isolated from Aseptic Body Fluid in a Large Tertiary Hospital, 2017-2018: Genetic Traits of blaNDM-Like and blaSIM-Like Genes as Determined by NGS.
The study identified NDM-5-producing CRKP and SIM-producing hvKP strains, highlighting the emergence of novel resistance mechanisms and the effectiveness of tigecycline-carbapenem combinations in treating these infections.
Characterization of the First Carbapenem-Resistant Pseudomonas aeruginosa Clinical Isolate Harboring bla(SIM-1) from the United States.
Characterization of the First Carbapenem-Resistant Pseudomonas aeruginosa Clinical Isolate Harboring blaSIM-1 from the United States.
The study reports the first identification of a carbapenem-resistant Pseudomonas aeruginosa isolate in the United States carrying the blaSIM-1 gene, which confers resistance to carbapenems.
Characterization of the First Carbapenem-Resistant Pseudomonas aeruginosa Clinical Isolate Harboring bla(SIM-1) from the United States.
Epidemiology of Klebsiella michiganensis Carrying Multidrug-Resistant IncHI5 Plasmids in the Southeast Coastal Area of China.
The study identified multiple AMR genes on IncHI5 plasmids in Klebsiella michiganensis, including beta-lactamases (blaCTX-M-3, blaTEM-1, blaSHV-12, blaIMP-4, blaNDM-1, blaOXA-1, blaOXA-16, blaSFO-1, blaSIM-1), aminoglycoside modifying enzymes (aacA4, arr3, aadA5, gcu37, dfrA1), chloramphenicol acetyltransferase (catA2), streptomycin resistance genes (strA, strB), macrolide resistance genes (msrAB, mph(A)), and quaternary ammonium compound resistance gene (qacG2).
The Emergence of Carbapenem Resistant Enterobacteriaceae Producing GIM-1 and SIM-1 Clinical Isolates in Khartoum-Sudan.
The study reports the emergence of GIM-1 and SIM-1 producing Enterobacteriaceae clinical isolates in Sudan, highlighting their resistance to carbapenems and other antibiotics.
Optimization and development of high-resolution melting curve analysis (HRMA) assay for detection of New Delhi metallo-β-lactamase (NDM) producing Pseudomonas aeruginosa.
The study developed and optimized a high-resolution melting curve analysis (HRMA) assay for detecting New Delhi metallo-beta-lactamase (NDM)-producing Pseudomonas aeruginosa. The HRMA method demonstrated high analytical sensitivity and specificity for identifying NDM and MBL genes in P. aeruginosa strains.
A bla (SIM-1) and mcr-9.2 harboring Klebsiella michiganensis strain reported and genomic characteristics of Klebsiella michiganensis.
The study reports a multidrug-resistant Klebsiella michiganensis strain 12084 harboring two bla SIM-1 genes and one mcr-9.2 gene, highlighting the presence of carbapenem and colistin resistance mechanisms.
Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii with Special Reference to Carbapenemases: A Systematic Review.
The paper reviews the molecular characteristics of carbapenem-resistant Acinetobacter baumannii, focusing on carbapenemases. It identifies several beta-lactamase genes, including OXA-23, OXA-51, OXA-58, VIM, NDM, IMP, KPC, and GES, which confer resistance to carbapenems. The study highlights the role of mobile genetic elements in the dissemination of these resistance genes.
Expanded catalogue of metagenome-assembled genomes reveals resistome characteristics and athletic performance-associated microbes in horse.
The study identified a diverse array of antibiotic resistance genes (ARG) in the horse gut microbiome, highlighting the widespread use of antibiotics in horse management. The resistome characteristics were analyzed alongside the identification of microbes associated with athletic performance.
Characterization of multidrug and heavy metal resistance of carbapenemases producing Klebsiella pneumoniae from poultry samples in Bangladesh.
The study identified multiple AMR genes, including bla TEM, bla SIM-1, bla IMP-4, bla OXA-48, and qnr B, in carbapenemase-producing Klebsiella pneumoniae isolates from poultry in Bangladesh, highlighting the prevalence of multidrug resistance.
Analyses of Extended-Spectrum-β-Lactamase, Metallo-β-Lactamase, and AmpC-β-Lactamase Producing Enterobacteriaceae from the Dairy Value Chain in India.
The study identified several β-lactamase genes, including bla CMY, bla MOX, bla FOX, bla EBC, bla DHA, bla CTX-M1, bla SHV, bla TEM, bla VIM, bla IMP, bla SPM, bla SIM, and bla GIM, in Enterobacteriaceae isolates from milk samples in India, highlighting the presence of multidrug-resistant bacteria in the dairy value chain.
Relative inhibitory activities of the broad-spectrum beta-lactamase inhibitor taniborbactam against metallo-beta-lactamases.
The study evaluates the inhibitory activity of taniborbactam against various metallo-beta-lactamases (MBLs), demonstrating that it effectively inhibits most NDM- and VIM-like enzymes but not SIM-1. Specific mutations in VIM-1 and NDM-1 were found to confer resistance to taniborbactam.
Multiplex Microarrays in 96-Well Plates Photoactivated with 4-Azidotetrafluorobenzaldehyde for the Identification and Quantification of beta-lactamase Genes and Their RNA Transcripts.
The study developed a novel microarray technique using photoactivated 96-well plates to identify and quantify beta-lactamase genes and their RNA transcripts. The method successfully detected various beta-lactamase genes, including ESBLs, inhibitor-resistant beta-lactamases, and carbapenemases, demonstrating high specificity and reproducibility.
Cefepime-taniborbactam activity against antimicrobial-resistant clinical isolates of Enterobacterales and Pseudomonas aeruginosa: GEARS global surveillance programme 2018-22.
Cefepime-taniborbactam showed potent in vitro activity against Enterobacterales and P. aeruginosa, particularly effective against isolates with carbapenemase genes such as blaIMP, blaNDM, and blaVIM, as well as those with mutations in ftsI, ompK35, and ompK36.
Critical resistance to carbapenem and aminoglycosides in Pseudomonas aeruginosa: spread of bla(NDM)/16S methylase armA harboring isolates with intrinsic resistance mechanisms in Kerman, Iran.
The study identified multiple carbapenemase genes (bla_NDM, bla_IMP, bla_VIM, bla_SIM, bla_GES) and the 16S rRNA methylase gene armA in carbapenem-resistant Pseudomonas aeruginosa isolates from Kerman, Iran. These genes contribute to resistance against carbapenems and aminoglycosides, highlighting the complex resistance mechanisms in these isolates.
Global Epidemiology and Antimicrobial Resistance of Metallo-β-Lactamase (MBL)-Producing Acinetobacter Clinical Isolates: A Systematic Review.
The study identifies bla VIM, bla IMP, and bla NDM as the most commonly detected MBL genes in Acinetobacter clinical isolates globally, with high resistance rates to carbapenems, cephalosporins, and fluoroquinolones.
Clonal dissemination of carbapenem-resistant ST477 Klebsiella michiganensis co-producing NDM-1, SFO-1, and VEB-3 in a Chinese hospital.
The study identifies the clonal dissemination of carbapenem-resistant ST477 Klebsiella michiganensis co-producing NDM-1, SFO-1, and VEB-3 in a Chinese hospital, highlighting the role of a self-transmissible plasmid in the spread of these resistance genes.
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