blaSMB

metallobetalactamase

Validation StatusConfirmed2+ DBs

Overview

Mechanism: hydrolysis
Validation Method: cloning in E. coli + susceptibility testing
Drug Classes: Beta-lactams, MEROPENEM, ERTAPENEM, AMOXICILLIN, CEFOXITIN, IMIPENEM, CEFIXIME, CEFEPIME, AMPICILLIN+CLAVULANIC ACID, AMPICILLIN, CARBAPENEM, CEFOTAXIME, CEFTAZIDIME, AMOXICILLIN+CLAVULANIC ACID, PIPERACILLIN+TAZOBACTAM, PIPERACILLIN, Carbapenem
Organisms: Serratia marcescens, Escherichia coli, Acinetobacter
Geographic Location: India, Japan
Papers: 2
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Papers2

SMB-1, a novel subclass B3 metallo-beta-lactamase, associated with ISCR1 and a class 1 integron, from a carbapenem-resistant Serratia marcescens clinical isolate.

PMID 21876060 · 2011

The study identifies SMB-1, a novel subclass B3 metallo-beta-lactamase, which confers resistance to various beta-lactam antibiotics, including carbapenems, in a carbapenem-resistant Serratia marcescens clinical isolate.

Gene Information

Gene Name: blaSMB
Allele: blaSMB-1
Encodes: metallobetalactamase
Source Database: Reslit
Mechanism: hydrolysis
Confers Resistance To: Beta-lactams
Organisms Tested In: • Serratia marcescens
• Escherichia coli
Geographic Location: Japan
Validation Method: cloning in E. coli + susceptibility testing
Sequence Accession: AB636283

SMB-1, a novel subclass B3 metallo-beta-lactamase, associated with ISCR1 and a class 1 integron, from a carbapenem-resistant Serratia marcescens clinical isolate.

PMID 21876060 · 2011

Gene Information

Gene Name: blaSMB
Allele: blaSMB-1
Encodes: subclass B3 metallo-beta-lactamase SMB-1
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Serratia marcescens
Sequence Accession: AB636283.1
Protein Accession: BAL14456.1
Notes: Chromosomal metallo beta-lactamase

SMB-1, a novel subclass B3 metallo-beta-lactamase, associated with ISCR1 and a class 1 integron, from a carbapenem-resistant Serratia marcescens clinical isolate.

PMID 21876060 · 2011

Gene Information

Gene Name: blaSMB
Allele: blaSMB-1
Encodes: subclass B3 metallo-beta-lactamase SMB-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Serratia marcescens
Sequence Accession: AB636283.1
Protein Accession: BAL14456.1
Notes: Chromosomal metallo beta-lactamase

SMB-1, a novel subclass B3 metallo-beta-lactamase, associated with ISCR1 and a class 1 integron, from a carbapenem-resistant Serratia marcescens clinical isolate.

PMID 21876060 · 2011

Gene Information

Gene Name: blaSMB
Allele: blaSMB-1
Encodes: subclass B3 metallo-beta-lactamase SMB-1, SMB beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCARBAPENEMCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Serratia marcescens
Sequence Accession: AB636283.1
Protein Accession: BAL14456.1
Notes: Chromosomal metallo beta-lactamase, ARO:3000854

SMB-1, a novel subclass B3 metallo-beta-lactamase, associated with ISCR1 and a class 1 integron, from a carbapenem-resistant Serratia marcescens clinical isolate.

PMID 21876060 · 2011

Gene Information

Gene Name: blaSMB
Allele: blaSMB-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Serratia marcescens
Sequence Accession: AB636283
Notes: Chromosomal metallo beta-lactamase

Metagenome of a polluted river reveals a reservoir of metabolic and antibiotic resistance genes.

PMID 33902720 · 2019

The study identified a diverse range of antibiotic resistance genes in the Yamuna River, including metallo-beta-lactamases such as bla NDM-1, bla NDM-8, and others, indicating a significant reservoir of resistance in the river's microbial community.

Gene Information

Gene Name: blaSMB
Allele: blaSMB-1
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis
Confers Resistance To: Carbapenem
Organisms Tested In: • Acinetobacter
Geographic Location: India
Validation Method: metagenomic analysis
Sequence Accession: SRR8870486|SRR8870487|SRR8870488|SRR8870489

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