blaTEM-1

Validation StatusCandidate

Overview

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
S130G	-	prevents irreversible cross-linking of the inhibitor to Ser130	Escherichia coli	penicillins	Reslit	Candidate

Papers1

Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase.

The Ser130Gly substitution prevents irreversible cross-linking of the inhibitor to Ser130, leading to resistance.

Protein Change: S130G
Organisms: Escherichia coli
Confers Resistance To: penicillins
Effect on Function: prevents irreversible cross-linking of the inhibitor to Ser130
Source Database: Reslit