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blaTHIN-B

metallo-beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaTHIN-B

Browse AMR rules for blaTHIN-B

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: expression in E. coli and in vitro susceptibility testing
Drug Classes: Ampicillin, Piperacillin, Cefotaxime, Cephalothin, Cefoxitin, Ceftazidime, Cefepime, Imipenem, Meropenem, Carbapenem, Cephalosporin, CARBAPENEM
Organisms: Janthinobacterium lividum, Escherichia coli, Pseudomonas aeruginosa
Geographic Location: China
Alleles: 3
Papers: 3
Databases: Card DatabaseReference Gene CatalogReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
bla_THIN-B	Reslit	2	Ampicillin, Piperacillin +9	Janthinobacterium lividum +1	-	2001, 2004	AJ250876	-
blaTHIN-B

Papers3

1

Metallo-beta-lactamase Producers in Environmental Microbiota: New Molecular Class B Enzyme in Janthinobacterium lividum.

PMID 11181369 · 2001

The study identifies a new metallo-beta-lactamase, bla_THIN-B, in Janthinobacterium lividum, which confers resistance to multiple β-lactam antibiotics.

Gene Information

Gene Name: blaTHIN-B
Allele: bla_THIN-B
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: AmpicillinPiperacillinCefotaximeCephalothinCefoxitinCeftazidimeCefepimeImipenemMeropenem
Organisms Tested In: • Janthinobacterium lividum
• Escherichia coli
Validation Method: expression in E. coli and in vitro susceptibility testing
Sequence Accession: AJ250876

2

Biochemical characterization of the THIN-B metallo-beta-lactamase of Janthinobacterium lividum.

PMID 15561856 · 2004

The THIN-B metallo-beta-lactamase from Janthinobacterium lividum was overproduced and biochemically characterized, showing activity against carbapenems and cephalosporins.

Gene Information

Gene Name: blaTHIN-B
Allele: bla_THIN-B
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: CarbapenemCephalosporin
Organisms Tested In: • Janthinobacterium lividum
• Escherichia coli
Validation Method: purification and biochemical analysis

3

Biochemical characterization of the THIN-B metallo-beta-lactamase of Janthinobacterium lividum.

PMID 15561856 · 2004

Gene Information

Gene Name: blaTHIN-B
Allele: blaTHIN-B
Encodes: subclass B3 metallo-beta-lactamase THIN-B
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Janthinobacterium lividum
Sequence Accession: AJ250876.1
Protein Accession: CAC33832.1
Notes: ARO:3000851

4

Biochemical characterization of the THIN-B metallo-beta-lactamase of Janthinobacterium lividum.

PMID 15561856 · 2004

Gene Information

Gene Name: blaTHIN-B
Allele: blaTHIN-B
Encodes: subclass B3 metallo-beta-lactamase THIN-B, THIN-B beta-lactamase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: CARBAPENEM
Organisms Tested In: • Janthinobacterium lividum
Sequence Accession: AJ250876.1
Protein Accession: CAC33832.1
Notes: ARO:3000851

5

Optimal treatment of ceftazidime-avibactam and aztreonam-avibactam against bloodstream infections or lower respiratory tract infections caused by extensively drug-resistant or pan drug-resistant (XDR/PDR) Pseudomonas aeruginosa.

PMID 37457958 · 2023

The study identifies several metallo-beta-lactamases (IND-6, SLB-1, THIN-B, IMP-45, VIM-1, VIM-2) associated with resistance in XDR/PDR P. aeruginosa. It highlights the effectiveness of aztreonam-avibactam (AZA) against isolates producing IMP-45, VIM-1, or VIM-2, and suggests optimized two-step administration therapy (OTAT) as a promising treatment strategy.

Gene Information

Gene Name: blaTHIN-B
Allele: THIN-B
Encodes: metallobeta-lactamase
Source Database: Reslit
Confers Resistance To: Carbapenem
Organisms Tested In: • Pseudomonas aeruginosa
Geographic Location: China
Validation Method: whole-genome sequencing
Sequence Accession: PRJNA967114