Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
metallo-beta-lactamase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaTMB-1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | carbapenems, cephalosporins +16 | Achromobacter xylosoxidans +3 | Libya, Libya|Japan, Japan | 2012, 2017, 2021 | FR771847 | CBY88906.1 |
| blaTMB-2 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | MEROPENEM, ERTAPENEM +15 | Acinetobacter pittii +3 | Japan, Libya|Japan | 2013, 2014, 2017 | AB758277.1 | BAM73612.1 |
Genetic and biochemical characterization of a novel metallo-beta-lactamase, TMB-1, from an Achromobacter xylosoxidans strain isolated in Tripoli, Libya.
The study identifies TMB-1, a novel metallo-beta-lactamase from Achromobacter xylosoxidans, which confers resistance to carbapenems and cephalosporins through hydrolytic activity.
Genetic and biochemical characterization of a novel metallo-β-lactamase, TMB-1, from an Achromobacter xylosoxidans strain isolated in Tripoli, Libya.
Genetic and biochemical characterization of a novel metallo-β-lactamase, TMB-1, from an Achromobacter xylosoxidans strain isolated in Tripoli, Libya.
Genetic and biochemical characterization of a novel metallo-β-lactamase, TMB-1, from an Achromobacter xylosoxidans strain isolated in Tripoli, Libya.
Genetic and biochemical characterization of a novel metallo-β-lactamase, TMB-1, from an Achromobacter xylosoxidans strain isolated in Tripoli, Libya.
Detection of tripoli metallo-β-lactamase 2 (TMB-2), a variant of blaTMB-1, in clinical isolates of Acinetobacter spp. in Japan.
Detection of tripoli metallo-β-lactamase 2 (TMB-2), a variant of blaTMB-1, in clinical isolates of Acinetobacter spp. in Japan.
Detection of tripoli metallo-β-lactamase 2 (TMB-2), a variant of blaTMB-1, in clinical isolates of Acinetobacter spp. in Japan.
Detection of tripoli metallo-β-lactamase 2 (TMB-2), a variant of blaTMB-1, in clinical isolates of Acinetobacter spp. in Japan.
Invasive infection caused by carbapenem-resistant Acinetobacter soli, Japan.
The study reports a case of infection with carbapenem-resistant Acinetobacter soli producing TMB-2 and OXA-58 carbapenemases.
Structural Insights into TMB-1 and the Role of Residues 119 and 228 in Substrate and Inhibitor Binding.
The study characterizes TMB-1 and TMB-2, metallo-beta-lactamases that confer resistance to carbapenems. Mutations at residues 119 (E119Q, E119S, E119A) and 228 (S228P) affect catalytic efficiency and substrate specificity.
Structural Insights into TMB-1 and the Role of Residues 119 and 228 in Substrate and Inhibitor Binding.
The study characterizes TMB-1 and TMB-2, metallo-beta-lactamases that confer resistance to carbapenems. Mutations at residues 119 (E119Q, E119S, E119A) and 228 (S228P) affect catalytic efficiency and substrate specificity.
Genomic characterization of triple-carbapenemase-producing Acinetobacter baumannii.
The study characterizes a clinical isolate of Acinetobacter baumannii, OCU_Ac16a, which harbors three carbapenemase genes: bla_NDM-1, bla_TMB-1, and bla_OXA-58. Each of these genes contributes to the high-level resistance of the strain to β-lactam antibiotics, highlighting the clinical significance of multiple-carbapenemase producers.
No comments yet. Be the first to comment!