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Explore antimicrobial resistance genes from the literature
metallo-beta-lactamase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaTMB-1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | Carbapenem, Cephalosporin +16 |
| Libya, Libya|Japan |
| 2012, 2017 |
| FR771847 |
| CBY88906.1 |
| blaTMB-2 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | MEROPENEM, ERTAPENEM +14 | Acinetobacter pittii +3 | Japan, Libya|Japan | 2013, 2014, 2017 | AB758277.1 | BAM73612.1 |
| bla_TMB-1 | Reslit | 1 | Carbapenem | Acinetobacter baumannii | Japan | 2021 | AP023077|AP023078|AP023079|AP023080|BLWH01000001|BLWH01000743 | - |
Genetic and biochemical characterization of a novel metallo-beta-lactamase, TMB-1, from an Achromobacter xylosoxidans strain isolated in Tripoli, Libya.
The study identifies TMB-1, a novel metallo-beta-lactamase from Achromobacter xylosoxidans, which confers resistance to carbapenems and cephalosporins through hydrolytic activity.
Genetic and biochemical characterization of a novel metallo-β-lactamase, TMB-1, from an Achromobacter xylosoxidans strain isolated in Tripoli, Libya.
Genetic and biochemical characterization of a novel metallo-β-lactamase, TMB-1, from an Achromobacter xylosoxidans strain isolated in Tripoli, Libya.
Genetic and biochemical characterization of a novel metallo-β-lactamase, TMB-1, from an Achromobacter xylosoxidans strain isolated in Tripoli, Libya.
Genetic and biochemical characterization of a novel metallo-β-lactamase, TMB-1, from an Achromobacter xylosoxidans strain isolated in Tripoli, Libya.
Detection of tripoli metallo-β-lactamase 2 (TMB-2), a variant of blaTMB-1, in clinical isolates of Acinetobacter spp. in Japan.
Detection of tripoli metallo-β-lactamase 2 (TMB-2), a variant of blaTMB-1, in clinical isolates of Acinetobacter spp. in Japan.
Detection of tripoli metallo-β-lactamase 2 (TMB-2), a variant of blaTMB-1, in clinical isolates of Acinetobacter spp. in Japan.
Detection of tripoli metallo-β-lactamase 2 (TMB-2), a variant of blaTMB-1, in clinical isolates of Acinetobacter spp. in Japan.
Invasive infection caused by carbapenem-resistant Acinetobacter soli, Japan.
The study reports a case of infection with carbapenem-resistant Acinetobacter soli producing TMB-2 and OXA-58 carbapenemases.
Structural Insights into TMB-1 and the Role of Residues 119 and 228 in Substrate and Inhibitor Binding.
The study characterizes TMB-1 and TMB-2, metallo-beta-lactamases that confer resistance to carbapenems. Mutations at residues 119 (E119Q, E119S, E119A) and 228 (S228P) affect catalytic efficiency and substrate specificity.
Structural Insights into TMB-1 and the Role of Residues 119 and 228 in Substrate and Inhibitor Binding.
The study characterizes TMB-1 and TMB-2, metallo-beta-lactamases that confer resistance to carbapenems. Mutations at residues 119 (E119Q, E119S, E119A) and 228 (S228P) affect catalytic efficiency and substrate specificity.
Genomic characterization of triple-carbapenemase-producing Acinetobacter baumannii.
The study characterizes a clinical isolate of Acinetobacter baumannii, OCU_Ac16a, which harbors three carbapenemase genes: bla_NDM-1, bla_TMB-1, and bla_OXA-58. Each of these genes contributes to the high-level resistance of the strain to β-lactam antibiotics, highlighting the clinical significance of multiple-carbapenemase producers.
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