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blaTRU

class C beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaTRU

Browse AMR rules for blaTRU

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic inactivation
Validation Method: cloning in E. coli + MIC testing
Drug Classes: Cephalothin, Cefoxitin, CEPHALOSPORIN, AMOXICILLIN, CEFOXITIN, AMPICILLIN+CLAVULANIC ACID, AMPICILLIN, CEFOTAXIME, CEFTAZIDIME, AMOXICILLIN+CLAVULANIC ACID, PIPERACILLIN+TAZOBACTAM, PIPERACILLIN
Organisms: Aeromonas enteropelogenes, Escherichia coli
Alleles: 3
Papers: 1
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
bla_TRU-1	Reslit	1	Cephalothin, Cefoxitin	Aeromonas enteropelogenes +1	-	2010	EU046614	-
blaTRU-1	Card Database

Papers1

1

Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes.

PMID 20124004 · 2010

The study identifies TRU-1, a class C beta-lactamase from Aeromonas enteropelogenes, which confers resistance to cephalothin and cefoxitin. The gene was cloned and expressed in E. coli, demonstrating its role in beta-lactam resistance.

Gene Information

Gene Name: blaTRU
Allele: bla_TRU-1
Encodes: class C beta-lactamase
Source Database: Reslit
Confers Resistance To: CephalothinCefoxitin
Organisms Tested In: • Aeromonas enteropelogenes
• Escherichia coli
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: EU046614

2

Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes.

PMID 20124004 · 2010

Gene Information

Gene Name: blaTRU
Allele: blaTRU-1
Encodes: class C beta-lactamase TRU-1
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: CEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Aeromonas enteropelogenes
Sequence Accession: EU046614.1
Protein Accession: ABW05394.1
Notes: Chromosomal class C beta-lactamase

3

Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes.

PMID 20124004 · 2010

Gene Information

Gene Name: blaTRU
Allele: blaTRU-1
Encodes: class C beta-lactamase TRU-1
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: CEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Aeromonas enteropelogenes
Sequence Accession: EU046614.1
Protein Accession: ABW05394.1
Notes: Chromosomal class C beta-lactamase

4

Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes.

PMID 20124004 · 2010

Gene Information

Gene Name: blaTRU
Allele: blaTRU-1
Encodes: class C beta-lactamase TRU-1, TRU beta-lactamase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: CEPHALOSPORINAMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Aeromonas enteropelogenes
Sequence Accession: EU046614.1
Protein Accession: ABW05394.1
Notes: Chromosomal class C beta-lactamase, ARO:3004450

5

Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes.

PMID 20124004 · 2010

Gene Information

Gene Name: blaTRU
Allele: blaTRU
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: AMOXICILLINCEFOXITINAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Aeromonas enteropelogenes
Sequence Accession: EU046614
Notes: Chromosomal class C beta-lactamase