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Explore antimicrobial resistance genes from the literature

blaVEB

beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to blaVEB

Browse AMR rules for blaVEB

Validation StatusSupported

Overview

Mechanism: hydrolysis of β-lactam antibiotics
Validation Method: cloning in E. coli + MIC testing
Drug Classes: ceftazidime, cefotaxime, aztreonam, piperacillin, ticarcillin, amoxicillin, cefepime, cefoxitin, cephalothin, imipenem
Organisms: Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Enterobacter sakazakii, Acinetobacter baumannii, Pseudomonas aeruginosa
Geographic Location: Bangkok, Thailand, France, India, Thailand
Alleles: 2
Papers: 5
Databases: Reslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
blaVEB-1	Reslit	4	ceftazidime, cefotaxime +5	Escherichia coli +5	France, Bangkok, Thailand, Thailand	1999, 2001, 2003	AF010416	-

Papers5

1

Molecular and biochemical characterization of VEB-1, a novel class A extended-spectrum beta-lactamase encoded by an Escherichia coli integron gene.

PMID 10049269 · 1999

VEB-1 is a novel class A extended-spectrum beta-lactamase encoded by an Escherichia coli integron gene, which confers high-level resistance to various beta-lactam antibiotics including ceftazidime, cefotaxime, aztreonam, cefuroxime, piperacillin, ticarcillin, and amoxicillin.

Gene Information

Gene Name: blaVEB
Allele: blaVEB-1
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of β-lactam antibiotics
Confers Resistance To: ceftazidimecefotaximeaztreonampiperacillinticarcillinamoxicillin
Organisms Tested In: • Escherichia coli
• Klebsiella pneumoniae
Geographic Location: France
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: AF010416

2

Molecular epidemiology of the integron-located VEB-1 extended-spectrum beta-lactamase in nosocomial enterobacterial isolates in Bangkok, Thailand.

PMID 11136767 · 2001

The study identifies the VEB-1 extended-spectrum beta-lactamase as a significant cause of ceftazidime resistance in nosocomial enterobacterial isolates in Bangkok, Thailand. The gene is located on class 1 integrons and is associated with other resistance genes such as blaOXA-10 and arr-2.

Gene Information

Gene Name: blaVEB
Allele: blaVEB-1
Encodes: extended-spectrum beta-lactamase
Source Database: Reslit
Confers Resistance To: ceftazidimecefotaximeaztreonam
Organisms Tested In: • Escherichia coli
• Enterobacter cloacae
• Enterobacter sakazakii
• Klebsiella pneumoniae
Geographic Location: Bangkok, Thailand
Validation Method: PCR, sequencing, and MIC testing

3

Outbreak of extended-spectrum beta-lactamase VEB-1-producing isolates of Acinetobacter baumannii in a French hospital.

PMID 12904353 · 2003

The study identifies the extended-spectrum beta-lactamase VEB-1 in Acinetobacter baumannii for the first time, highlighting its role in multidrug resistance and the challenges in detecting ESBLs in this species.

Gene Information

Gene Name: blaVEB
Allele: blaVEB-1
Encodes: extended-spectrum beta-lactamase
Source Database: Reslit
Mechanism: beta-lactam hydrolysis
Confers Resistance To: ceftazidimecefotaximecefepime
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: France
Validation Method: PCR, sequencing, MIC testing

4

IS1999 increases expression of the extended-spectrum beta-lactamase VEB-1 in Pseudomonas aeruginosa.

PMID 12923109 · 2003

IS1999 increases the expression of the extended-spectrum beta-lactamase VEB-1 in Pseudomonas aeruginosa, leading to increased resistance to ceftazidime.

Gene Information

Gene Name: blaVEB
Allele: blaVEB-1
Encodes: extended-spectrum beta-lactamase
Source Database: Reslit
Confers Resistance To: ceftazidime
Organisms Tested In: • Pseudomonas aeruginosa
• Escherichia coli
Geographic Location: Thailand
Validation Method: expression experiments and promoter study

5

Functional and structural characterization of the genetic environment of an extended-spectrum beta-lactamase blaVEB gene from a Pseudomonas aeruginosa isolate obtained in India.

PMID 15328086 · 2004

The study identifies and characterizes the blaVEB-1a gene, an extended-spectrum beta-lactamase, in a Pseudomonas aeruginosa isolate from India, highlighting its unique genetic environment and resistance mechanisms.

Gene Information

Gene Name: blaVEB
Allele: blaVEB-1a
Encodes: extended-spectrum beta-lactamase
Source Database: Reslit
Mechanism: beta-lactamase
Confers Resistance To: cefoxitincefotaximeceftazidimecephalothinimipenem
Organisms Tested In: • Pseudomonas aeruginosa
• Escherichia coli
Geographic Location: India
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: AY444814|AY444815