blaVIM
carbapenem-hydrolyzing metallo-beta-lactamase
Overview
- Mechanism
- hydrolysis of beta-lactam antibiotics
- Validation Method
- cloning in E. coli DH10B and expression, MIC testing
- Drug Classes
- carbapenems, ceftazidime, cefepime, ticarcillin, ticarcillin/clavulanate, piperacillin, piperacillin/tazobactam, imipenem, meropenem, aztreonam, cephalosporins, penicillins, piperacillin-tazobactam
- Organisms
- Pseudomonas aeruginosa, Escherichia coli, Achromobacter xylosoxydans, Pseudomonas putida, Pseudomonas stutzeri, Acinetobacter spp., Enterobacter cloacae, Klebsiella pneumoniae
- Geographic Location
- Argentina, Colombia, Europe, France, Greece +7 more
- Alleles
- 14
- Papers
- 20
- Databases
- Reslit
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| blaVIM-2 | Reslit | 7 | carbapenems, imipenem +6 | Pseudomonas aeruginosa +5 | France, Taiwan, Europe, Korea, Japan, United States | 2000, 2001, 2003, 2004, 2005 | AF191564 | - |
| blaVIM | Reslit | 1 | carbapenems, ceftazidime +5 | Pseudomonas aeruginosa | Italy | 2000 | - | - |
| bla(VIM-2) | Reslit | 2 | carbapenems | Pseudomonas aeruginosa +1 | France, Korea | 2001, 2002 | AF263519|AF263520 | - |
| bla(VIM-1) | Reslit | 1 | carbapenems | Achromobacter xylosoxydans +1 | Italy | 2001 | AJ278514|AJ278515 | - |
| blaVIM-3 | Reslit | 1 | carbapenems | Pseudomonas aeruginosa | Taiwan | 2001 | AF300454 | - |
| bla(VIM-4) | Reslit | 1 | carbapenems | Pseudomonas aeruginosa | Greece | 2002 | AY135661 | - |
| blaVIM-7 | Reslit | 1 | carbapenems, cephalosporins +1 | Pseudomonas aeruginosa +1 | United States | 2004 | AJ536835 | - |
| blaVIM-6 | Reslit | 1 | imipenem, meropenem +4 | Pseudomonas putida | Singapore | 2004 | AY165025|AY251052|AY250709 | - |
| blaVIM-8 | Reslit | 1 | carbapenems | Pseudomonas aeruginosa | Colombia | 2004 | AY524987 | - |
| blaVIM-1 | Reslit | 1 | carbapenems | Pseudomonas aeruginosa | Italy | 2005 | Y18050|AJ581664|AJ581665 | - |
| bla(VIM-11) | Reslit | 1 | carbapenems | Pseudomonas aeruginosa | Argentina | 2005 | AY605049 | - |
| blaVIM-5 | Reslit | 1 | carbapenems | Enterobacter cloacae +1 | Turkey | 2005 | AY910754|DQ023222 | - |
| blaVIM-11a | Reslit | 1 | imipenem, meropenem | Pseudomonas aeruginosa | Argentina | 2005 | - | - |
| blaVIM-12 | Reslit | 1 | carbapenems, cephalosporins +1 | Klebsiella pneumoniae +1 | Greece | 2005 | DQ143913 | - |
Characterization of VIM-2, a carbapenem-hydrolyzing metallo-beta-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France.
The study characterizes VIM-2, a carbapenem-hydrolyzing metallo-beta-lactamase, and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France.
Gene Information
- Gene Name
- blaVIM
- Allele
- blaVIM-2
- Encodes
- carbapenem-hydrolyzing metallo-beta-lactamase
- Source Database
- Reslit
- Confers Resistance To
- carbapenems
- Organisms Tested In
- • Pseudomonas aeruginosa• Escherichia coli
- Geographic Location
- France
- Validation Method
- cloning in E. coli DH10B and expression, MIC testing
- Sequence Accession
- AF191564
Carbapenem-resistant Pseudomonas aeruginosa with acquired bla(vim) metallo-beta-lactamase determinants, Italy.
The study identifies the acquisition of the blaVIM metallo-beta-lactamase gene in carbapenem-resistant Pseudomonas aeruginosa isolates from Italy, highlighting its role in resistance to multiple antibiotics.
Gene Information
- Gene Name
- blaVIM
- Allele
- blaVIM
- Encodes
- metallo-beta-lactamase
- Source Database
- Reslit
- Confers Resistance To
- carbapenemsceftazidimecefepimeticarcillinticarcillin/clavulanatepiperacillinpiperacillin/tazobactam
- Organisms Tested In
- • Pseudomonas aeruginosa
- Geographic Location
- Italy
- Validation Method
- colony-blot hybridization assay
Characterization of Class 1 integrons from Pseudomonas aeruginosa that contain the bla(VIM-2) carbapenem-hydrolyzing beta-lactamase gene and of two novel aminoglycoside resistance gene cassettes.
The study identifies two novel aminoglycoside resistance gene cassettes, aacA29a and aacA29b, which confer resistance to several aminoglycosides. Additionally, the bla(VIM-2) gene, which encodes a carbapenem-hydrolyzing beta-lactamase, was characterized in Pseudomonas aeruginosa isolates.
Gene Information
- Gene Name
- blaVIM
- Allele
- bla(VIM-2)
- Encodes
- beta-lactamase
- Source Database
- Reslit
- Confers Resistance To
- carbapenems
- Organisms Tested In
- • Pseudomonas aeruginosa
- Geographic Location
- France
- Validation Method
- cloning in E. coli + disk diffusion
- Sequence Accession
- AF263519|AF263520
In70 of plasmid pAX22, a bla(VIM-1)-containing integron carrying a new aminoglycoside phosphotransferase gene cassette.
The study identifies a new integron, In70, carrying the bla(VIM-1) gene, which confers resistance to beta-lactams, including carbapenems, and three aminoglycoside resistance genes: aacA4, aphA15, and aadA1.
Gene Information
- Gene Name
- blaVIM
- Allele
- bla(VIM-1)
- Encodes
- metallo-beta-lactamase
- Source Database
- Reslit
- Mechanism
- hydrolysis of beta-lactam antibiotics
- Confers Resistance To
- carbapenems
- Organisms Tested In
- • Achromobacter xylosoxydans• Escherichia coli
- Geographic Location
- Italy
- Validation Method
- expression in E. coli and MIC testing
- Sequence Accession
- AJ278514|AJ278515
Metallo-beta-lactamases in clinical Pseudomonas isolates in Taiwan and identification of VIM-3, a novel variant of the VIM-2 enzyme.
The study identifies VIM-3, a novel variant of the VIM-2 metallo-beta-lactamase, in clinical Pseudomonas isolates in Taiwan, highlighting the prevalence of VIM-2-related enzymes among these isolates.
Gene Information
- Gene Name
- blaVIM
- Allele
- blaVIM-2
- Encodes
- metallo-beta-lactamase
- Source Database
- Reslit
- Confers Resistance To
- carbapenems
- Organisms Tested In
- • Pseudomonas aeruginosa• Pseudomonas putida• Pseudomonas stutzeri
- Geographic Location
- Taiwan
- Validation Method
- PCR and sequencing
- Sequence Accession
- AF300454
Metallo-beta-lactamases in clinical Pseudomonas isolates in Taiwan and identification of VIM-3, a novel variant of the VIM-2 enzyme.
The study identifies VIM-3, a novel variant of the VIM-2 metallo-beta-lactamase, in clinical Pseudomonas isolates in Taiwan, highlighting the prevalence of VIM-2-related enzymes among these isolates.
Gene Information
- Gene Name
- blaVIM
- Allele
- blaVIM-3
- Encodes
- metallo-beta-lactamase
- Source Database
- Reslit
- Confers Resistance To
- carbapenems
- Organisms Tested In
- • Pseudomonas aeruginosa
- Geographic Location
- Taiwan
- Validation Method
- PCR and sequencing
- Sequence Accession
- AF300454
Multidrug-resistant Pseudomonas aeruginosa producing PER-1 extended-spectrum serine-beta-lactamase and VIM-2 metallo-beta-lactamase.
The study identifies the presence of blaPER-1 and blaVIM-2 genes in a multidrug-resistant Pseudomonas aeruginosa isolate, which confer resistance to multiple beta-lactam antibiotics.
Gene Information
- Gene Name
- blaVIM
- Allele
- blaVIM-2
- Encodes
- metallo-beta-lactamase
- Source Database
- Reslit
- Confers Resistance To
- imipenemmeropenemceftazidimecefepimeaztreonampiperacillin
- Organisms Tested In
- • Pseudomonas aeruginosa
- Geographic Location
- Europe
- Validation Method
- PCR and sequencing
bla(VIM-2) cassette-containing novel integrons in metallo-beta-lactamase-producing Pseudomonas aeruginosa and Pseudomonas putida isolates disseminated in a Korean hospital.
The study identifies bla(VIM-2) as a novel metallo-beta-lactamase gene responsible for carbapenem resistance in Pseudomonas aeruginosa and Pseudomonas putida isolates in a Korean hospital.
Gene Information
- Gene Name
- blaVIM
- Allele
- bla(VIM-2)
- Encodes
- metallo-beta-lactamase
- Source Database
- Reslit
- Confers Resistance To
- carbapenems
- Organisms Tested In
- • Pseudomonas aeruginosa• Pseudomonas putida
- Geographic Location
- Korea
- Validation Method
- sequencing and enzymatic assays
- Sequence Accession
- AY029772|AF327064
Novel variant (bla(VIM-4)) of the metallo-beta-lactamase gene bla(VIM-1) in a clinical strain of Pseudomonas aeruginosa.
The study identifies a novel variant of the metallo-beta-lactamase gene bla(VIM-1), termed bla(VIM-4), in a carbapenem-resistant Pseudomonas aeruginosa strain. This variant differs by a single nucleotide from bla(VIM-1), leading to a Ser-to-Arg change at amino acid position 175 of the VIM-1 enzyme.
Gene Information
- Gene Name
- blaVIM
- Allele
- bla(VIM-4)
- Encodes
- metallo-beta-lactamase
- Source Database
- Reslit
- Confers Resistance To
- carbapenems
- Organisms Tested In
- • Pseudomonas aeruginosa
- Geographic Location
- Greece
- Validation Method
- PCR and nucleotide sequencing
- Sequence Accession
- AY135661
Evaluation of the Hodge test and the imipenem-EDTA double-disk synergy test for differentiating metallo-beta-lactamase-producing isolates of Pseudomonas spp. and Acinetobacter spp.
The study evaluated the Hodge test and imipenem-EDTA double-disk synergy test for detecting metallo-beta-lactamase (MBL)-producing isolates of Pseudomonas and Acinetobacter. It identified blaIMP-1 and blaVIM-2 as the MBL genes responsible for carbapenem resistance.
Gene Information
- Gene Name
- blaVIM
- Allele
- blaVIM-2
- Encodes
- metallo-beta-lactamase
- Source Database
- Reslit
- Mechanism
- hydrolyzes carbapenems
- Confers Resistance To
- carbapenems
- Organisms Tested In
- • Pseudomonas aeruginosa• Acinetobacter spp.
- Geographic Location
- Korea
- Validation Method
- PCR amplification
blaVIM-7, an evolutionarily distinct metallo-beta-lactamase gene in a Pseudomonas aeruginosa isolate from the United States.
The study identifies blaVIM-7, a novel metallo-beta-lactamase gene in a Pseudomonas aeruginosa isolate from the United States, which confers resistance to multiple beta-lactam antibiotics.
Gene Information
- Gene Name
- blaVIM
- Allele
- blaVIM-7
- Encodes
- metallo-beta-lactamase
- Source Database
- Reslit
- Confers Resistance To
- carbapenemscephalosporinspenicillins
- Organisms Tested In
- • Pseudomonas aeruginosa• Escherichia coli
- Geographic Location
- United States
- Validation Method
- cloning in E. coli + MIC testing
- Sequence Accession
- AJ536835
Class 1 integron containing metallo-beta-lactamase gene blaVIM-2 in Pseudomonas aeruginosa clinical strains isolated in Japan.
The study identifies the blaVIM-2 gene in Pseudomonas aeruginosa clinical strains in Japan, highlighting its presence in a class 1 integron and suggesting horizontal spread among strains.
Gene Information
- Gene Name
- blaVIM
- Allele
- blaVIM-2
- Encodes
- metallo-beta-lactamase
- Source Database
- Reslit
- Confers Resistance To
- carbapenems
- Organisms Tested In
- • Pseudomonas aeruginosa
- Geographic Location
- Japan
- Validation Method
- PCR and sequencing
- Sequence Accession
- AY242981|AY242982|AY242983|AY242984|AY294333
IMP-1 and a novel metallo-beta-lactamase, VIM-6, in fluorescent pseudomonads isolated in Singapore.
The study identifies blaIMP-1 and a novel metallo-beta-lactamase, VIM-6, in carbapenem-resistant Pseudomonas spp. isolates from Singapore. Both genes confer resistance to various beta-lactam antibiotics.
Gene Information
- Gene Name
- blaVIM
- Allele
- blaVIM-6
- Encodes
- metallo-beta-lactamase
- Source Database
- Reslit
- Confers Resistance To
- imipenemmeropenemaztreonamceftazidimecefepimepiperacillin-tazobactam
- Organisms Tested In
- • Pseudomonas putida
- Geographic Location
- Singapore
- Validation Method
- sequencing and MIC testing
- Sequence Accession
- AY165025|AY251052|AY250709
Outbreak of carbapenem-resistant Pseudomonas aeruginosa producing VIM-8, a novel metallo-beta-lactamase, in a tertiary care center in Cali, Colombia.
The study identifies VIM-8, a novel metallo-beta-lactamase, as the resistance mechanism in a carbapenem-resistant Pseudomonas aeruginosa outbreak in Colombia.
Gene Information
- Gene Name
- blaVIM
- Allele
- blaVIM-8
- Encodes
- metallo-beta-lactamase
- Source Database
- Reslit
- Confers Resistance To
- carbapenems
- Organisms Tested In
- • Pseudomonas aeruginosa
- Geographic Location
- Colombia
- Validation Method
- sequencing of DNA from a representative isolate
- Sequence Accession
- AY524987
Metallo-beta-lactamase-Producing Gram-Negative Bacilli: Laboratory-Based Surveillance in Cooperation with 13 Clinical Laboratories in the Kinki Region of Japan.
The study identified metallo-beta-lactamase (MBL) genes, including blaIMP-1, blaIMP-2, and blaVIM-2, in various gram-negative bacilli, highlighting the widespread distribution of MBL-producing organisms in the Kinki region of Japan.
Gene Information
- Gene Name
- blaVIM
- Allele
- blaVIM-2
- Encodes
- metallo-beta-lactamase
- Source Database
- Reslit
- Confers Resistance To
- carbapenemspenicillins
- Organisms Tested In
- • Pseudomonas aeruginosa• Enterobacter cloacae
- Geographic Location
- Japan
- Validation Method
- PCR and DNA sequencing
Clonal Relatedness and Conserved Integron Structures in Epidemiologically Unrelated Pseudomonas aeruginosa Strains Producing the VIM-1 Metallo-β-lactamase from Different Italian Hospitals.
The study identifies the VIM-1 metallo-beta-lactamase as a key resistance factor in Pseudomonas aeruginosa isolates from Italian hospitals, highlighting the conserved integron structures and clonal relatedness among the isolates.
Gene Information
- Gene Name
- blaVIM
- Allele
- blaVIM-1
- Encodes
- metallo-beta-lactamase
- Source Database
- Reslit
- Confers Resistance To
- carbapenems
- Organisms Tested In
- • Pseudomonas aeruginosa
- Geographic Location
- Italy
- Validation Method
- sequencing and hybridization assays
- Sequence Accession
- Y18050|AJ581664|AJ581665
Novel variant (bla(VIM-11)) of the metallo-{beta}-lactamase bla(VIM) family in a GES-1 extended-spectrum-{beta}-lactamase-producing Pseudomonas aeruginosa clinical isolate in Argentina.
The study reports the identification of a novel variant of the metallo-beta-lactamase bla(VIM) family, designated bla(VIM-11), in a GES-1 extended-spectrum-beta-lactamase-producing Pseudomonas aeruginosa clinical isolate in Argentina.
Gene Information
- Gene Name
- blaVIM
- Allele
- bla(VIM-11)
- Encodes
- metallo-beta-lactamase
- Source Database
- Reslit
- Confers Resistance To
- carbapenems
- Organisms Tested In
- • Pseudomonas aeruginosa
- Geographic Location
- Argentina
- Validation Method
- DNA sequencing and MIC testing
- Sequence Accession
- AY605049
First nosocomial outbreak of Pseudomonas aeruginosa producing an integron-borne metallo-beta-lactamase (VIM-2) in the United States.
The study reports the first nosocomial outbreak of Pseudomonas aeruginosa producing the metallo-beta-lactamase VIM-2 in the United States, highlighting the emergence of carbapenemases on mobile genetic elements.
Gene Information
- Gene Name
- blaVIM
- Allele
- blaVIM-2
- Encodes
- metallo-beta-lactamase
- Source Database
- Reslit
- Mechanism
- hydrolyzes carbapenems and other beta-lactams
- Confers Resistance To
- carbapenems
- Organisms Tested In
- • Pseudomonas aeruginosa
- Geographic Location
- United States
- Validation Method
- PCR and sequencing
- Sequence Accession
- AY943084
Genetic and enzymatic properties of metallo-beta-lactamase VIM-5 from a clinical isolate of Enterobacter cloacae.
The study characterizes the metallo-beta-lactamase VIM-5 from a clinical isolate of Enterobacter cloacae, demonstrating its ability to hydrolyze carbapenems and confer resistance.
Gene Information
- Gene Name
- blaVIM
- Allele
- blaVIM-5
- Encodes
- metallo-beta-lactamase
- Source Database
- Reslit
- Mechanism
- hydrolysis
- Confers Resistance To
- carbapenems
- Organisms Tested In
- • Enterobacter cloacae• Escherichia coli
- Geographic Location
- Turkey
- Validation Method
- purification and enzymatic activity testing
- Sequence Accession
- AY910754|DQ023222
Sensitive EDTA-Based Microbiological Assays for Detection of Metallo-β-Lactamases in Nonfermentative Gram-Negative Bacteria.
The study describes the development of a sensitive microbiological assay (EIM) for detecting metallo-β-lactamases (MBLs) in nonfermentative gram-negative bacteria. It identifies several MBL genes, including bla VIM-11a, bla IMP-7, bla SPM-1, bla L1-like, bla GOB-like, bla IND-like, and bla BcII, which confer resistance to carbapenems.
Gene Information
- Gene Name
- blaVIM
- Allele
- blaVIM-11a
- Encodes
- metallobeta-lactamase
- Source Database
- Reslit
- Mechanism
- hydrolyzes carbapenems
- Confers Resistance To
- imipenemmeropenem
- Organisms Tested In
- • Pseudomonas aeruginosa
- Geographic Location
- Argentina
- Validation Method
- spectrophotometric assay and PCR
VIM-12, a novel plasmid-mediated metallo-beta-lactamase from Klebsiella pneumoniae that resembles a VIM-1/VIM-2 hybrid.
The study identifies blaVIM-12, a novel plasmid-mediated metallo-beta-lactamase from Klebsiella pneumoniae, which shows characteristics of both VIM-1 and VIM-2.
Gene Information
- Gene Name
- blaVIM
- Allele
- blaVIM-12
- Encodes
- metallo-beta-lactamase
- Source Database
- Reslit
- Mechanism
- hydrolysis of beta-lactam ring
- Confers Resistance To
- carbapenemscephalosporinspenicillins
- Organisms Tested In
- • Klebsiella pneumoniae• Escherichia coli
- Geographic Location
- Greece
- Validation Method
- cloning in E. coli + agar dilution MICs
- Sequence Accession
- DQ143913
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