bla_ctxm15

beta-lactamase

Validation StatusCandidate

Overview

Mechanism: hydrolyzes beta-lactam antibiotics
Validation Method: whole-genome sequencing
Drug Classes: Ceftriaxone
Organisms: Salmonella enterica subsp. enterica serovar Typhi
Geographic Location: Pakistan
Papers: 1
Databases: Reslit

Papers1

Whole-Genome Sequencing Analysis of Drug-Resistant Salmonella Typhi in Children.

PMID 41156578 · 2025

The study identified several AMR genes and mutations in drug-resistant Salmonella Typhi isolates from children, including bla_CTXM15, bla_TEM1B, qnrS1, aac6'Ia, catA1, dfrA7, sul1, qacEΔ1, and the gyrA_S83F mutation, which are associated with resistance to various antibiotics such as ciprofloxacin, ampicillin, chloramphenicol, and sulfamethoxazole.

Gene Information

Gene Name: bla_ctxm15
Allele: bla_CTXM15
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: hydrolyzes beta-lactam antibiotics
Confers Resistance To: Ceftriaxone
Organisms Tested In: • Salmonella enterica subsp. enterica serovar Typhi
Geographic Location: Pakistan
Validation Method: whole-genome sequencing
Sequence Accession: NCBI:CP079815|NCBI:CP079816|NCBI:CP079817|NCBI:CP079818|NCBI:CP079819|NCBI:CP079820|NCBI:CP079821|NCBI:CP079822|NCBI:CP079823|NCBI:CP079824|NCBI:CP079825|NCBI:CP079826|NCBI:CP079827|NCBI:CP079828|NCBI:CP079829|NCBI:CP079830|NCBI:CP079831|NCBI:CP079832|NCBI:CP079833|NCBI:CP079834|NCBI:CP079835|NCBI:CP079836|NCBI:CP079837|NCBI:CP079838|NCBI:CP079839|NCBI:CP079840|NCBI:CP079841|NCBI:CP079842|NCBI:CP079843

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bla_ctxm15

Gene Information