bla_oxa-23-like

oxacillinase

Validation StatusSupported

Overview

Mechanism: carbapenem resistance
Validation Method: PCR and sequencing
Drug Classes: Carbapenem
Organisms: Acinetobacter baumannii, Acinetobacter calcoaceticus, Acinetobacter lwoffii, Acinetobacter pittii, Acinetobacter nosocomialis
Geographic Location: Brazil, Europe, Iran
Papers: 3
Databases: Reslit

Papers3

Carbapenem Resistance in Acinetobacter baumannii and Other Acinetobacter spp. Causing Neonatal Sepsis: Focus on NDM-1 and Its Linkage to ISAba125.

PMID 27551277 · 2016

The study identifies NDM-1 as a major carbapenem resistance determinant in Acinetobacter spp. causing neonatal sepsis, along with other beta-lactamases like OXA-23-like, OXA-58-like, PER-1, VEB-2, and aminoglycoside modifying enzymes such as aac(6')-Ib, aac(6')-Ib-cr, and armA.

Gene Information

Gene Name: bla_oxa-23-like
Allele: bla_OXA-23-like
Encodes: oxacillinase
Source Database: Reslit
Mechanism: carbapenem resistance
Confers Resistance To: Carbapenem
Organisms Tested In: • Acinetobacter baumannii
• Acinetobacter calcoaceticus
• Acinetobacter lwoffii
Geographic Location: Europe
Validation Method: PCR and sequencing

Dissemination of carbapenem-resistant Acinetobacter baumannii in patients with burn injuries.

PMID 28268175 · 2017

The study identified bla_OXA-23-like and bla_OXA-24-like genes as significant contributors to carbapenem resistance in Acinetobacter baumannii isolates from burn patients.

Gene Information

Gene Name: bla_oxa-23-like
Allele: bla_OXA-23-like
Encodes: carbapenemase
Source Database: Reslit
Confers Resistance To: Carbapenem
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: Iran
Validation Method: PCR and sequencing
Sequence Accession: HG937619|HG937620|HG937621

Species distribution, sequence types and antimicrobial resistance of Acinetobacter spp. from cystic fibrosis patients.

PMID 29283077 · 2018

The study identifies the bla_OXA-23-like gene as a key factor in carbapenem resistance among multidrug-resistant Acinetobacter baumannii strains isolated from cystic fibrosis patients.

Gene Information

Gene Name: bla_oxa-23-like
Allele: bla_OXA-23-like
Encodes: oxacillinase
Source Database: Reslit
Confers Resistance To: Carbapenem
Organisms Tested In: • Acinetobacter baumannii
• Acinetobacter pittii
• Acinetobacter nosocomialis
Geographic Location: Brazil
Validation Method: multiplex PCR

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bla_oxa-23-like

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