blab2

metallo-beta-lactamase

Validation StatusCandidate

Overview

Validation Method: PCR and sequencing
Drug Classes: Carbapenem
Organisms: Chryseobacterium (Flavobacterium) meningosepticum, Escherichia coli
Geographic Location: United Kingdom|USA|France
Papers: 2
Databases: Reslit

Papers2

Carbapenemases of Chryseobacterium (Flavobacterium) meningosepticum: distribution of blaB and characterization of a novel metallo-beta-lactamase gene, blaB3, in the type strain, NCTC 10016.

PMID 10817691 · 2000

The study characterizes the blaB, blaB2, and blaB3 genes, which encode metallo-beta-lactamases in Chryseobacterium (Flavobacterium) meningosepticum, contributing to carbapenem resistance.

Gene Information

Gene Name: blab2
Allele: blaB2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: Carbapenem
Organisms Tested In: • Chryseobacterium (Flavobacterium) meningosepticum
Geographic Location: United Kingdom|USA|France
Validation Method: PCR and sequencing
Sequence Accession: AF126542|AF162284

Development and evaluation of fARGene, a computational tool for the detection of antibiotic resistance genes in metagenomic data

PMID 30935407 · 2023

The study presents fARGene, a method for identifying and reconstructing antibiotic resistance genes from metagenomic data, demonstrating the detection of 221 ARGs, 58 of which were previously unreported, with 81% providing a resistance phenotype in E. coli.

Gene Information

Gene Name: blab2
Allele: blaB2
Encodes: metallo-beta-lactamase
Source Database: Reslit
Confers Resistance To: Carbapenem
Organisms Tested In: • Escherichia coli
Validation Method: synthesis and expression in E. coli followed by CarbaNP test

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