blacmy-2–like

beta-lactamase

Validation StatusCandidate

Overview

Mechanism: decrease in porins and increase in CMY-2-like β-lactamases
Validation Method: LC-MS/MS and Western blotting
Drug Classes: Carbapenem
Organisms: Escherichia coli
Papers: 1
Databases: Reslit

Papers1

Liquid Chromatography-Tandem Mass Spectrometry Analysis Demonstrates a Decrease in Porins and Increase in CMY-2 β-Lactamases in Escherichia coli Exposed to Increasing Concentrations of Meropenem.

PMID 35295306 · 2022

The study identified that mutations in the ompC gene leading to premature stop codons and gene interruptions contributed to meropenem resistance in E. coli. Additionally, an increase in CMY-2 β-lactamase production was observed in resistant mutants.

Gene Information

Gene Name: blacmy-2–like
Allele: blaCMY-2–like
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: decrease in porins and increase in CMY-2-like β-lactamases
Confers Resistance To: Carbapenem
Organisms Tested In: • Escherichia coli
Validation Method: LC-MS/MS and Western blotting
Sequence Accession: NC_000913

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blacmy-2–like

Gene Information