Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
beta-lactamase
Overview
Anti-Restriction Protein, KlcA(HS), Promotes Dissemination of Carbapenem Resistance.
The study identifies the bla KPC−2 gene and the KlcA HS gene as being commonly coexisting in carbapenem-resistant K. pneumoniae isolates, with KlcA HS promoting transformation efficiency by countering host restriction-modification systems.
Extensively Drug-Resistant Klebsiella pneumoniae Causing Nosocomial Bloodstream Infections in China: Molecular Investigation of Antibiotic Resistance Determinants, Informing Therapy, and Clinical Outcomes.
The study identified multiple AMR genes and mutations in XDR K. pneumoniae isolates, including bla KPC−2, rmtB, aac(6′)-Ib, APH(3′)-Ia, AAC(3)-IV, qnrS, qnrB, aac(6′)-Ib-cr, bla CTX−M−14, bla CTX−M−65, bla SHV−11, bla TEM, bla CMY, bla DHA−1, gyrA, and parC, which contribute to resistance against various antibiotics.
Characteristics of Carbapenem-Resistant Enterobacteriaceae in Ready-to-Eat Vegetables in China.
The study identified bla NDM and bla KPC−2 as the primary carbapenemase genes in carbapenem-resistant Enterobacteriaceae (CRE) isolated from ready-to-eat vegetables in China. These genes were found in Escherichia coli, Citrobacter freundii, and Klebsiella pneumoniae, highlighting the potential risk of CRE dissemination through the food chain.
Transcriptional Landscape of a bla (KPC-2) Plasmid and Response to Imipenem Exposure in Escherichia coli TOP10.
The study identifies the expression of AMR genes bla KPC−2, bla TEM−1, aph(3′)-I, and mepM in E. coli TOP10 harboring the pBIC1a plasmid, highlighting their role in resistance to carbapenems, beta-lactams, aminoglycosides, and beta-lactams respectively.
An Outbreak of Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae in an Intensive Care Unit of a Major Teaching Hospital in Wenzhou, China.
The study identified carbapenem-resistant and hypervirulent Klebsiella pneumoniae isolates carrying bla KPC−2, aac(3')-Ia, aac(6')-Ib, ANT(3')-Ia, rmtB, rmtC, qnrB, qnrS, oqxA, bla SHV−11, bla CTX−M−2 group, bla CTX−M−9 group, bla TEM−1, bla CMY−2, and bla DHA genes, contributing to multidrug resistance.
Drug Susceptibility and Molecular Epidemiology of Klebsiella pneumoniae Bloodstream Infection in ICU Patients in Shanghai, China.
The study identified bla CTX-M-14, bla CTX-M-15, bla CTX-M-55, and bla KPC-2 as the most prevalent resistance genes in K. pneumoniae isolates from ICU patients in Shanghai, China.
Genetic characteristics of clinical carbapenem-resistant Klebsiella pneumoniae: epidemic ST11 KPC-2-producing strains and non-negligible NDM-5-producing strains with diverse STs.
The study characterizes 30 carbapenem-resistant Klebsiella pneumoniae (CRKP) strains, identifying bla KPC−2 and bla NDM−5 as the primary carbapenemase genes. bla KPC−2 was predominantly found in ST11 strains, while bla NDM−5 was present in strains belonging to multiple STs. The study highlights the role of specific plasmids in the dissemination of these resistance genes.
Comprehensive genomic epidemiology and antimicrobial resistance profiles of clinical Klebsiella pneumoniae species complex isolates from a tertiary hospital in Wenzhou, China (2019-2021).
The study identified a variety of antimicrobial resistance genes in clinical Klebsiella pneumoniae species complex isolates, including bla KPC−2, bla CTX−M, bla SHV, aac(6')-Ib, aadA1, aadA2, aph(3')-Ia, oqxAB, qnrB19, qnrS1, tet(A), tet(D), sul1, sul2, sul3, cmlA1, floR, fosA, and fosA3. These genes confer resistance to multiple classes of antibiotics, highlighting the complexity of antimicrobial resistance in these isolates.
Molecular epidemiological analysis and research on resistance and virulence of carbapenem-resistant Klebsiella pneumoniae in a tertiary hospital from 2016 to 2023.
The study identified bla KPC−2 as the predominant carbapenem resistance gene in 93% of CRKP isolates, with additional resistance genes including bla NDM−5, bla IMP−38, bla TEM−1, dfrA14, CTX-M−3, TEM−213, and QnrS8. Virulence genes such as entB, mrkD, fimH, and ybtS were commonly detected.
Carbapenem-resistant Klebsiella pneumoniae gut colonization and subsequent infection in pediatric intensive care units in shanghai, China.
The study identified bla KPC−2, bla NDM−1, and bla NDM−5 as the most prevalent carbapenemase genes in CRKP isolates from anal swabs and infection specimens in pediatric ICU patients. ST11 was the most common sequence type, and bla KPC−2 was significantly more frequent in infection isolates.
Cefiderocol-resistant pathogens in German hospital wastewater: a reservoir for multidrug resistance.
The study identifies multiple AMR genes, including bla NDM−1, bla VIM−1, bla OXA−48, and bla KPC−2, in cefiderocol-resistant isolates from German hospital wastewater, highlighting the presence of multidrug-resistant pathogens with diverse resistance mechanisms.
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