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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
carbapenemase
Overview
Molecular eidemiology of carbapenem-resistant Enterobacter cloacae complex in a tertiary hospital in Shandong, China.
The study identified NDM-5 carbapenemase produced by ST171 and NDM-1 carbapenemase produced by ST418 as the leading causes of carbapenem resistance in Enterobacter cloacae complex strains in a tertiary hospital in Shandong, China. A novel ST (ST1965) was also detected, carrying the bla NDM−1 gene.
Pathogenomics analysis of high-risk clone ST147 multidrug-resistant Klebsiella pneumoniae isolated from a patient in Egypt.
The study identifies multiple AMR genes in the MDR-KP isolate WSF99, including various beta-lactamases, carbapenemase, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, and others, highlighting the complex resistance profile of this high-risk clone.
Genetic characteristics of clinical carbapenem-resistant Klebsiella pneumoniae: epidemic ST11 KPC-2-producing strains and non-negligible NDM-5-producing strains with diverse STs.
The study characterizes 30 carbapenem-resistant Klebsiella pneumoniae (CRKP) strains, identifying bla KPC−2 and bla NDM−5 as the primary carbapenemase genes. bla KPC−2 was predominantly found in ST11 strains, while bla NDM−5 was present in strains belonging to multiple STs. The study highlights the role of specific plasmids in the dissemination of these resistance genes.
Genomic dynamics of high-risk carbapenem-resistant klebsiella pneumoniae clones carrying hypervirulence determinants in Egyptian clinical settings.
The study identifies high-risk, extensively carbapenem-resistant Klebsiella pneumoniae strains carrying hypervirulence determinants in Egyptian clinical settings, highlighting the emergence of convergent strains with multiple resistance and virulence genes.
Detection of carbapenemases in Enterobacterales and other Gram-negative bacilli recovered from hospital and municipal wastewater in Mexico City.
The study identified several carbapenemase genes, including bla KPC, bla NDM, bla VIM−2, bla OXA−48, bla NDM−1, and bla NDM−5, in various Gram-negative bacteria from hospital and municipal wastewater in Mexico City.
Genomic and molecular characterization of a ceftazidime-avibactam resistant Klebsiella pneumoniae strain isolated from a Chinese tertiary hospital.
The study identifies a ceftazidime-avibactam resistant Klebsiella pneumoniae strain carrying the bla NDM−5 gene, which confers resistance to carbapenems and other beta-lactam antibiotics. The strain also possesses other resistance genes including bla CTX−M−65, bla SHV−103, and bla TEM−1, contributing to multidrug resistance.
Molecular epidemiological analysis and research on resistance and virulence of carbapenem-resistant Klebsiella pneumoniae in a tertiary hospital from 2016 to 2023.
The study identified bla KPC−2 as the predominant carbapenem resistance gene in 93% of CRKP isolates, with additional resistance genes including bla NDM−5, bla IMP−38, bla TEM−1, dfrA14, CTX-M−3, TEM−213, and QnrS8. Virulence genes such as entB, mrkD, fimH, and ybtS were commonly detected.
Carbapenem-resistant Klebsiella pneumoniae gut colonization and subsequent infection in pediatric intensive care units in shanghai, China.
The study identified bla KPC−2, bla NDM−1, and bla NDM−5 as the most prevalent carbapenemase genes in CRKP isolates from anal swabs and infection specimens in pediatric ICU patients. ST11 was the most common sequence type, and bla KPC−2 was significantly more frequent in infection isolates.
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