Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
carbapenemase
Overview
Changing carbapenemase gene pattern in an epidemic multidrug-resistant Acinetobacter baumannii lineage causing multiple outbreaks in central Italy.
The study identifies blaOXA-23-like and blaOXA-58-like carbapenemase genes as the primary drivers of carbapenem resistance in an epidemic multidrug-resistant Acinetobacter baumannii lineage in central Italy.
OXA beta-lactamase-mediated carbapenem resistance in Acinetobacter baumannii.
The study identified blaOXA-23-like and blaOXA-51-like genes as the most common OXA carbapenamases, and blaVIM as the most common metallo-beta-lactamase contributing to carbapenem resistance in Acinetobacter baumannii.
The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace.
The paper discusses various virulence factors and mechanisms contributing to the pathogenicity and antibiotic resistance of Acinetobacter baumannii, including biofilm formation, surface polysaccharides, and outer membrane proteins.
Emergence of 16S rRNA methylase-producing Acinetobacter baumannii and Pseudomonas aeruginosa isolates in hospitals in Vietnam.
The study identifies the emergence of 16S rRNA methylase-producing Acinetobacter baumannii and Pseudomonas aeruginosa isolates in hospitals in Vietnam, highlighting the presence of armA and rmtB genes conferring resistance to aminoglycosides, along with bla OXA-23-like and bla OXA-51-like genes contributing to carbapenem resistance.
Types and prevalence of carbapenem-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex in Northern Taiwan.
The study identifies the prevalence of carbapenem-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex in Northern Taiwan, highlighting the presence of blaOXA-24-like, blaOXA-51-like, blaOXA-23-like, and IMP-1 genes as major contributors to carbapenem resistance.
Rapid molecular characterization of Acinetobacter baumannii clones with rep-PCR and evaluation of carbapenemase genes by new multiplex PCR in Hospital District of Helsinki and Uusimaa.
The study identified OXA-23-like, OXA-58, and OXA-24-like carbapenemase genes as the primary contributors to carbapenem resistance in Acinetobacter baumannii isolates. These genes were detected using a novel multiplex real-time PCR assay, highlighting their prevalence and association with specific clonal lineages.
Molecular characterization of oxacillinases among carbapenem-resistant Acinetobacter baumannii nosocomial isolates in a Saudi hospital.
The study identified blaOXA-23-like, blaOXA-58-like, and blaOXA-40-like genes as the main contributors to carbapenem resistance in Acinetobacter baumannii isolates in a Saudi hospital, with ISAba1 elements enhancing their expression.
Transition of blaOXA-58-like to blaOXA-23-like in Acinetobacter baumannii Clinical Isolates in Southern China: An 8-Year Study.
The study identified blaOXA-23-like and blaOXA-58-like carbapenemase genes in Acinetobacter baumannii clinical isolates, showing their transition and varying resistance levels to carbapenems.
The role of vancomycin in addition with colistin and meropenem against colistin-sensitive multidrug resistant Acinetobacter baumannii causing severe infections in a Paediatric Intensive Care Unit.
The study identified the bla OXA-23-like gene as a cause of carbapenem resistance in multidrug-resistant Acinetobacter baumannii, demonstrating the effectiveness of colistin, vancomycin, and meropenem combination therapy against these strains.
Antibiotic Resistance Profile and Distribution of Oxacillinase Genes Among Clinical Isolates of Acinetobacter baumannii in Shiraz Teaching Hospitals, 2012 - 2013.
The study identified the prevalence of bla OXA-23-like, bla OXA-24-like, and bla OXA-58-like genes among multidrug-resistant Acinetobacter baumannii isolates in Shiraz, Iran, highlighting the significance of these carbapenemase genes in carbapenem resistance.
Dissemination of carbapenemases producing Gram negative bacteria in the Middle East.
The study reviews the dissemination of carbapenemase-producing Gram-negative bacteria in the Middle East, highlighting the prevalence of KPC, VIM, IMP, NDM, and OXA-48 enzymes in various bacterial species such as Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa.
Antimicrobial Combinations against Pan-Resistant Acinetobacter baumannii Isolates with Different Resistance Mechanisms.
The study identified bla OXA-23-like, bla OXA-143-like, bla OXA-51-like, and bla IMP genes as major resistance mechanisms in pan-resistant Acinetobacter baumannii isolates. These genes conferred resistance to carbapenems, and the study highlighted the synergistic effects of various antibiotic combinations against these isolates.
Molecular Epidemiology and Clinical Impact of Acinetobacter calcoaceticus-baumannii Complex in a Belgian Burn Wound Center.
The study identified OXA-51-like and OXA-23-like oxacillinase genes in Acinetobacter calcoaceticus-baumannii complex isolates, contributing to carbapenem resistance.
Two Multiplex Real-Time PCR Assays to Detect and Differentiate Acinetobacter baumannii and Non- baumannii Acinetobacter spp. Carrying blaNDM, blaOXA-23-Like, blaOXA-40-Like, blaOXA-51-Like, and blaOXA-58-Like Genes.
The study developed two multiplex real-time PCR assays to detect and differentiate Acinetobacter baumannii and non-baumannii Acinetobacter spp. carrying blaNDM, blaOXA-23-like, blaOXA-40-like, blaOXA-51-like, and blaOXA-58-like genes, which are responsible for carbapenem resistance.
The role of the genetic elements bla oxa and IS Aba 1 in the Acinetobacter calcoaceticus-Acinetobacter baumannii complex in carbapenem resistance in the hospital setting.
The study identified bla OXA-23-like and bla OXA-51-like genes as significant contributors to carbapenem resistance in the Acinetobacter calcoaceticus-Acinetobacter baumannii complex, with IS Aba 1 playing a crucial role in enhancing resistance when located upstream of bla OXA-23-like.
In vitro Evaluation of the Colistin-Carbapenem Combination in Clinical Isolates of A. baumannii Using the Checkerboard, Etest, and Time-Kill Curve Techniques.
The study identified bla OXA-23-like, bla OXA-24-like, and bla OXA-51-like genes as contributors to carbapenem resistance in Acinetobacter baumannii isolates. The colistin-carbapenem combination showed additive effects in vitro.
Molecular characterization of beta-lactamase genes in clinical isolates of carbapenem-resistant Acinetobacter baumannii.
The study identified multiple beta-lactamase genes, including bla OXA-23-like, bla OXA-40-like, bla OXA-51-like, bla TEM, bla SHV, bla ampC, and bla ADC-7, in carbapenem-resistant Acinetobacter baumannii isolates. These genes contribute to resistance against carbapenems and other β-lactam antibiotics.
Distribution and Molecular Characterization of Acinetobacter baumannii International Clone II Lineage in Japan.
The study identified carbapenem resistance genes such as bla OXA-23-like, bla OXA-51-like, and bla IMP in Acinetobacter baumannii isolates, along with the bla ADC gene associated with cephalosporin resistance. These genes were found in different sequence types of A. baumannii, contributing to varying levels of antimicrobial resistance.
Different phenotypic and molecular mechanisms associated with multidrug resistance in Gram-negative clinical isolates from Egypt.
The study identified various AMR genes and mutations contributing to multidrug resistance in Gram-negative clinical isolates from Egypt, highlighting the role of efflux pumps and plasmid-mediated quinolone resistance.
blaOXA-23-like and blaTEM rather than blaOXA-51-like contributed to a high level of carbapenem resistance in Acinetobacter baumannii strains from a teaching hospital in Xi'an, China.
blaOXA-23-like and blaTEM were strongly associated with carbapenem resistance in Acinetobacter baumannii strains, while blaOXA-51-like did not contribute significantly to the resistance phenotype.
Endemic carbapenem-nonsusceptible Acinetobacter baumannii-calcoaceticus complex in intensive care units of the national referral hospital in Jakarta, Indonesia.
The study identified the bla OXA-23-like gene as a predominant carbapenem resistance gene in carbapenem-nonsusceptible Acinetobacter baumannii-calcoaceticus complex isolates.
Carbapenem-resistant Gram-negative pathogens in a German university medical center: Prevalence, clinical implications and the role of novel β-lactam/β-lactamase inhibitor combinations.
The study identified carbapenemase genes blaVIM-2, blaOXA-48, and blaOXA-23-like as the main contributors to carbapenem resistance in Pseudomonas aeruginosa, Enterobacteriaceae, and Acinetobacter baumannii, respectively.
Study of genetic diversity, biofilm formation, and detection of Carbapenemase, MBL, ESBL, and tetracycline resistance genes in multidrug-resistant Acinetobacter baumannii isolated from burn wound infections in Iran.
The study identified several AMR genes in multidrug-resistant Acinetobacter baumannii isolates, including bla OXA-23-like, bla OXA-40-like, bla OXA-51-like, bla VIM, bla PER-1, bla VEB-1, and tetB, which contribute to resistance against carbapenems, beta-lactams, and tetracyclines.
Evaluating the frequency of carbapenem and aminoglycoside resistance genes among clinical isolates of Acinetobacter baumannii from Ahvaz, south-west Iran.
The study identified several aminoglycoside resistance genes (aadA1, aadB, aphA6, aacC1) and carbapenemase genes (blaOXA-23-like, blaOXA-24-like, blaOXA-51-like, blaOXA-58-like) in Acinetobacter baumannii isolates from Ahvaz, Iran, highlighting the high prevalence of multidrug-resistant strains.
Activity of Imipenem, Meropenem, Cefepime, and Sulbactam in Combination with the β-Lactamase Inhibitor LN-1-255 against Acinetobacter spp.
LN-1-255 restored the efficacy of imipenem, meropenem, cefepime, and sulbactam against Acinetobacter spp., particularly against carbapenem-resistant A. baumannii isolates producing OXA-23-like and OXA-58-like beta-lactamases.
Two Acinetobacter baumannii Isolates Obtained From a Fatal Necrotizing Fasciitis Infection Display Distinct Genomic and Phenotypic Characteristics in Comparison to Type Strains.
The study characterizes two XDR Acinetobacter baumannii isolates, NFAb-1 and NFAb-2, obtained from a fatal necrotizing fasciitis case. These isolates exhibit resistance to multiple antibiotics, including carbapenems, aminoglycosides, fluoroquinolones, and others, indicating the presence of various AMR genes such as blaOXA-51-like, blaOXA-23-like, blaOXA-58-like, blaADC, blaNDM, blaKPC, aac(6')-Ib, aadA, ant(3'')-Ia, mph(A), erm(B), tet(A), tet(G), qnrS1, mexAB-oprM, acrAB-tolC, oqxAB, cat, cfr, and optrA.
Antibiotic Resistance and Genotypes of Nosocomial Strains of Acinetobacter baumannii in Kazakhstan.
The study identified blaOXA-23-like and blaOXA-58-like carbapenemase genes as the main mechanisms of carbapenem resistance in Acinetobacter baumannii isolates in Kazakhstan.
Surgical Site Infection Following Caesarean Section by Acinetobacter Species: A Report from a Hyperendemic Setting in the Brazilian Amazon Region.
The study identified carbapenem resistance in Acinetobacter isolates, primarily mediated by bla OXA-23-like and bla OXA-51-like genes in A. baumannii, and bla IMP-1 in A. nosocomialis. These genes conferred resistance to carbapenems.
Interplay between Meropenem and Human Serum Albumin on Expression of Carbapenem Resistance Genes and Natural Competence in Acinetobacter baumannii.
The study identifies that human serum albumin (HSA) enhances the expression of carbapenem resistance genes such as bla OXA-51-like, bla OXA-23-like, and carO in Acinetobacter baumannii, leading to increased resistance to carbapenems like meropenem, imipenem, and doripenem.
Deciphering Multidrug-Resistant Acinetobacter baumannii from a Pediatric Cancer Hospital in Egypt.
The study identified various AMR genes and mutations in multidrug-resistant Acinetobacter baumannii isolates from a pediatric cancer hospital in Egypt, highlighting the presence of bla NDM, bla OXA-23-like, bla OXA-51-like, and other resistance genes, along with mutations in pmrA and lptF contributing to colistin resistance.
Multidrug-Resistant Bacteria in a COVID-19 Hospital in Zagreb.
The study identified several AMR genes in multidrug-resistant bacteria isolated from a COVID-19 hospital in Zagreb, including bla CTX-M-15 in E. coli and various bla OXA variants in A. baumannii. These genes conferred resistance to beta-lactams and aminoglycosides.
The optimized carbapenem inactivation method for objective and accurate detection of carbapenemase-producing Acinetobacter baumannii.
The study identifies and characterizes several carbapenemase-encoding genes, including bla TEM, bla SHV, bla KPC, bla OXA-23-like, and bla OXA-51-like, in carbapenem-resistant Acinetobacter baumannii isolates.
Screening for Resistant Bacteria, Antimicrobial Resistance Genes, Sexually Transmitted Infections and Schistosoma spp. in Tissue Samples from Predominantly Vaginally Delivered Placentae in Ivory Coast and Ghana.
The study identified multiple beta-lactamase genes, including bla CTX-M, bla IMP, bla GES, bla VIM, bla OXA-58-like, bla NDM, bla OXA-23-like, bla OXA-48-like, and bla KPC, in placental tissue samples from Ivory Coast and Ghana. These genes confer resistance to various beta-lactam antibiotics, indicating a high prevalence of antimicrobial resistance in the studied region.
A global view on carbapenem-resistant Acinetobacter baumannii.
The study identifies and characterizes various carbapenemase genes, including bla OXA-23-like, bla OXA-40-like, bla NDM-1, and bla IMP-26, in carbapenem-resistant Acinetobacter baumannii isolates from diverse geographical regions.
Descriptive analysis of targeted carbapenemase genes and antibiotic susceptibility profiles among carbapenem-resistant Acinetobacter baumannii tested in the Antimicrobial Resistance Laboratory Network-United States, 2017-2020.
The study analyzed carbapenem-resistant Acinetobacter baumannii (CRAB) isolates and identified the presence of various carbapenemase genes, including bla KPC, bla NDM, bla OXA-23-like, and bla OXA-24/40-like. These genes contribute to extensive drug resistance in CRAB isolates.
16S rRNA amplicon sequencing and antimicrobial resistance profile of intensive care units environment in 41 Brazilian hospitals.
The study identified the frequent presence of antimicrobial resistance genes such as mecA, bla KPC-like, bla NDM-like, and bla OXA-23-like in ICU surfaces and sanitizers in Brazilian hospitals.
Gram-Negative Bacilli Blood Stream Infection in Patients with Severe Burns: Microbiological and Clinical Evidence from a 9-Year Cohort.
The study identified several carbapenemase genes, including bla VIM, bla GES, and various OXA-like genes, in Gram-negative bacilli causing bloodstream infections in burn patients, highlighting the prevalence of multidrug-resistant strains.
Clonality and the Phenotype-Genotype Correlation of Antimicrobial Resistance in Acinetobacter baumannii Isolates: A Multicenter Study of Clinical Isolates from Romania.
The study identifies several AMR genes in Acinetobacter baumannii isolates, including bla OXA-23-like, bla OXA-24/40-like, bla NDM, ArmA, ant(3")-I, and sul1, which are associated with resistance to carbapenems, aminoglycosides, and sulfonamides.
Whole-genome sequencing of Acinetobacter baumannii clinical isolates from a tertiary hospital in Terengganu, Malaysia (2011-2020), revealed the predominance of the Global Clone 2 lineage.
The study identified the predominance of the Global Clone 2 lineage of Acinetobacter baumannii in Terengganu, Malaysia, with a focus on the detection of various antimicrobial resistance genes, including bla OXA-23, bla ADC, bla NDM-1, and others, contributing to multidrug resistance.
Acinetobacter baumannii infection in critically ill patients with COVID-19 from Tehran, Iran: the prevalence, antimicrobial resistance patterns and molecular characteristics of isolates.
The study identified multiple antimicrobial resistance genes in Acinetobacter baumannii isolates from COVID-19 patients, including aac(6')-Ib, aac(3)-Ia, ant(2")-Ia, aph(3')-Ia, blaTEM, blaNDM, blaOXA-23-like, and blaOXA-24-like. These genes conferred resistance to various antibiotics, highlighting the challenge of treating multidrug-resistant infections.
Evaluation of QuickMIC system for rapid antimicrobial susceptibility testing of Gram-negative pathogens from positive blood cultures, including strains producing extended-spectrum β-lactamases and carbapenemases.
The study evaluated the QuickMIC system for rapid antimicrobial susceptibility testing of Gram-negative pathogens, including strains producing extended-spectrum β-lactamases (ESBLs) and carbapenemases. It identified several β-lactamase genes such as bla CTX-M, bla KPC, bla NDM, bla VIM, bla OXA-23-like, bla FIM, and bla VEB, which confer resistance to various beta-lactam antibiotics.
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