Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
carbapenem-hydrolyzing beta-lactamase
Overview
Molecular characterization of acinetobacter isolates collected in intensive care units of six hospitals in Florence, Italy, during a 3-year surveillance program: a population structure analysis.
The study identified the blaOXA-58-like gene as a major determinant of carbapenem resistance in Acinetobacter baumannii isolates, which was consistently associated with resistance across different clonal groups and hospitals.
Changing carbapenemase gene pattern in an epidemic multidrug-resistant Acinetobacter baumannii lineage causing multiple outbreaks in central Italy.
The study identifies blaOXA-23-like and blaOXA-58-like carbapenemase genes as the primary drivers of carbapenem resistance in an epidemic multidrug-resistant Acinetobacter baumannii lineage in central Italy.
The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace.
The paper discusses various virulence factors and mechanisms contributing to the pathogenicity and antibiotic resistance of Acinetobacter baumannii, including biofilm formation, surface polysaccharides, and outer membrane proteins.
Identification of blaOXA-51-like, blaOXA-58, blaDIM-1, and blaVIM carbapenemase genes in hospital Enterobacteriaceae isolates from Sierra Leone.
The study identifies blaOXA-51-like, blaOXA-58-like, blaDIM-1, and blaVIM carbapenemase genes in hospital Enterobacteriaceae isolates from Sierra Leone, highlighting the presence of these resistance genes in non-Acinetobacter species and emphasizing the need for molecular surveillance of carbapenemase gene circulation.
Antimicrobial resistance determinants in Acinetobacter baumannii isolates taken from military treatment facilities.
The study identified multiple antimicrobial resistance genes in Acinetobacter baumannii isolates from military treatment facilities, including bla OXA-51-like, bla OXA-23, bla GES-11, aac(6')-Ib, aacC1, aadB, aphA6, and others, highlighting the complex resistome of these isolates.
Molecular characterization of oxacillinases among carbapenem-resistant Acinetobacter baumannii nosocomial isolates in a Saudi hospital.
The study identified blaOXA-23-like, blaOXA-58-like, and blaOXA-40-like genes as the main contributors to carbapenem resistance in Acinetobacter baumannii isolates in a Saudi hospital, with ISAba1 elements enhancing their expression.
Transition of blaOXA-58-like to blaOXA-23-like in Acinetobacter baumannii Clinical Isolates in Southern China: An 8-Year Study.
The study identified blaOXA-23-like and blaOXA-58-like carbapenemase genes in Acinetobacter baumannii clinical isolates, showing their transition and varying resistance levels to carbapenems.
Antibiotic Resistance Profile and Distribution of Oxacillinase Genes Among Clinical Isolates of Acinetobacter baumannii in Shiraz Teaching Hospitals, 2012 - 2013.
The study identified the prevalence of bla OXA-23-like, bla OXA-24-like, and bla OXA-58-like genes among multidrug-resistant Acinetobacter baumannii isolates in Shiraz, Iran, highlighting the significance of these carbapenemase genes in carbapenem resistance.
Dissemination of carbapenemases producing Gram negative bacteria in the Middle East.
The study reviews the dissemination of carbapenemase-producing Gram-negative bacteria in the Middle East, highlighting the prevalence of KPC, VIM, IMP, NDM, and OXA-48 enzymes in various bacterial species such as Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa.
Effects of Saline, an Ambient Acidic Environment, and Sodium Salicylate on OXA-Mediated Carbapenem Resistance in Acinetobacter baumannii.
The study shows that OXA-58-like enzymes exhibit reduced carbapenemase activity under acidic conditions, leading to decreased carbapenem MICs in Acinetobacter baumannii.
Two Multiplex Real-Time PCR Assays to Detect and Differentiate Acinetobacter baumannii and Non- baumannii Acinetobacter spp. Carrying blaNDM, blaOXA-23-Like, blaOXA-40-Like, blaOXA-51-Like, and blaOXA-58-Like Genes.
The study developed two multiplex real-time PCR assays to detect and differentiate Acinetobacter baumannii and non-baumannii Acinetobacter spp. carrying blaNDM, blaOXA-23-like, blaOXA-40-like, blaOXA-51-like, and blaOXA-58-like genes, which are responsible for carbapenem resistance.
Dynamics of a Sporadic Nosocomial Acinetobacter calcoaceticus - Acinetobacter baumannii Complex Population.
The study identified 26 allelic variants of the bla OXA-51-like gene, including nine novel ones (OXA-554 to OXA-562), and detected the genetic structure IS Aba2 - bla OXA-58-like -IS Aba3 in carbapenem-resistant isolates of Acinetobacter baumannii.
Evaluating the frequency of carbapenem and aminoglycoside resistance genes among clinical isolates of Acinetobacter baumannii from Ahvaz, south-west Iran.
The study identified several aminoglycoside resistance genes (aadA1, aadB, aphA6, aacC1) and carbapenemase genes (blaOXA-23-like, blaOXA-24-like, blaOXA-51-like, blaOXA-58-like) in Acinetobacter baumannii isolates from Ahvaz, Iran, highlighting the high prevalence of multidrug-resistant strains.
Activity of Imipenem, Meropenem, Cefepime, and Sulbactam in Combination with the β-Lactamase Inhibitor LN-1-255 against Acinetobacter spp.
LN-1-255 restored the efficacy of imipenem, meropenem, cefepime, and sulbactam against Acinetobacter spp., particularly against carbapenem-resistant A. baumannii isolates producing OXA-23-like and OXA-58-like beta-lactamases.
Two Acinetobacter baumannii Isolates Obtained From a Fatal Necrotizing Fasciitis Infection Display Distinct Genomic and Phenotypic Characteristics in Comparison to Type Strains.
The study characterizes two XDR Acinetobacter baumannii isolates, NFAb-1 and NFAb-2, obtained from a fatal necrotizing fasciitis case. These isolates exhibit resistance to multiple antibiotics, including carbapenems, aminoglycosides, fluoroquinolones, and others, indicating the presence of various AMR genes such as blaOXA-51-like, blaOXA-23-like, blaOXA-58-like, blaADC, blaNDM, blaKPC, aac(6')-Ib, aadA, ant(3'')-Ia, mph(A), erm(B), tet(A), tet(G), qnrS1, mexAB-oprM, acrAB-tolC, oqxAB, cat, cfr, and optrA.
Antibiotic Resistance and Genotypes of Nosocomial Strains of Acinetobacter baumannii in Kazakhstan.
The study identified blaOXA-23-like and blaOXA-58-like carbapenemase genes as the main mechanisms of carbapenem resistance in Acinetobacter baumannii isolates in Kazakhstan.
Screening for Resistant Bacteria, Antimicrobial Resistance Genes, Sexually Transmitted Infections and Schistosoma spp. in Tissue Samples from Predominantly Vaginally Delivered Placentae in Ivory Coast and Ghana.
The study identified multiple beta-lactamase genes, including bla CTX-M, bla IMP, bla GES, bla VIM, bla OXA-58-like, bla NDM, bla OXA-23-like, bla OXA-48-like, and bla KPC, in placental tissue samples from Ivory Coast and Ghana. These genes confer resistance to various beta-lactam antibiotics, indicating a high prevalence of antimicrobial resistance in the studied region.
Acinetobacter Non-baumannii Species: Occurrence in Infections in Hospitalized Patients, Identification, and Antibiotic Resistance.
The study identified the presence of bla OXA-58-like and bla NDM carbapenemase genes in 4 out of 234 Anb isolates, contributing to carbapenem resistance in Acinetobacter bereziniae, Acinetobacter pittii, and Acinetobacter johnsonii.
Whole-genome sequencing of Acinetobacter baumannii clinical isolates from a tertiary hospital in Terengganu, Malaysia (2011-2020), revealed the predominance of the Global Clone 2 lineage.
The study identified the predominance of the Global Clone 2 lineage of Acinetobacter baumannii in Terengganu, Malaysia, with a focus on the detection of various antimicrobial resistance genes, including bla OXA-23, bla ADC, bla NDM-1, and others, contributing to multidrug resistance.
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