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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
serine beta-lactamase
Overview
Outcomes in Oxacillinases beta-lactamases (OXA-48) and New Delhi Metallo-beta-lactamase (NDM-1)-Producing, Carbapenem-Resistant Klebsiella Pneumoniae Isolates Obtained From Bloodstream Infections.
The study identified blaNDM and blaOXA48-like genes as the primary causes of carbapenem resistance in Klebsiella pneumoniae isolates from bloodstream infections. Both genes were associated with reduced susceptibility to carbapenems, with blaOXA48-like showing higher susceptibility to trimethoprim-sulphamethoxazole compared to blaNDM.
Uncovering the Resistance Mechanisms in Extended-Drug-Resistant Pseudomonas aeruginosa Clinical Isolates: Insights from Gene Expression and Phenotypic Tests.
The study identified bla GES-2, bla OXA48-like, bla NDM, bla SPM, and bla VIM as the main carbapenemase genes in MDR P. aeruginosa isolates. Overexpression of mex efflux pumps, particularly mex C, was strongly associated with multidrug resistance.
Evaluation of biofilm formation and carbapenem resistance in Klebsiella pneumoniae isolated from clinical samples at a rural hospital in western Uttar Pradesh.
The study identified blaNDM, blaOXA48-like, and coproducing blaNDM+blaOXA48 genes as major contributors to carbapenem resistance in K. pneumoniae isolates.
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